Preexisting chronic conditions for fatal outcome among SFTS patients: An observational Cohort Study.
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that is caused by a novel bunyavirus SFTSV. Currently our knowledge of the host-related factors that influence the pathogenesis of disease is inadequate to allow prediction of fatal outcome. Here we conducted a pros...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2019
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0007434 https://doaj.org/article/a424264fec394feeb83cf30a60f41c27 |
id |
ftdoajarticles:oai:doaj.org/article:a424264fec394feeb83cf30a60f41c27 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:a424264fec394feeb83cf30a60f41c27 2023-05-15T15:16:17+02:00 Preexisting chronic conditions for fatal outcome among SFTS patients: An observational Cohort Study. Shao-Fei Zhang Zhen-Dong Yang Mao-Lin Huang Zhi-Bo Wang Yuan-Yuan Hu Dong Miao Ke Dai Juan Du Ning Cui Chun Yuan Hao Li Xiao-Kun Li Xiao-Ai Zhang Pan-He Zhang Xian-Miao Mi Qing-Bin Lu Wei Liu 2019-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007434 https://doaj.org/article/a424264fec394feeb83cf30a60f41c27 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007434 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007434 https://doaj.org/article/a424264fec394feeb83cf30a60f41c27 PLoS Neglected Tropical Diseases, Vol 13, Iss 5, p e0007434 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007434 2022-12-31T10:05:03Z Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that is caused by a novel bunyavirus SFTSV. Currently our knowledge of the host-related factors that influence the pathogenesis of disease is inadequate to allow prediction of fatal outcome. Here we conducted a prospective study of the largest database on the SFTS patients, to identify the presence of comorbidities in SFTS, and estimate their effect on the fatal outcome. Among 2096 patients eligible for inclusion, we identified nine kinds of comorbidities, from which hyperlipidemia (12.2%; 95% CI: 10.8%-13.6%), hypertension (11.0%; 95% CI: 9.6%-12.3%), chronic viral hepatitis (CVH) (9.3%; 95% CI: 8.1%-10.5%), and diabetes mellitus (DM) (6.8%; 95% CI: 5.7%-7.9%) were prevalent. Higher risk of death was found in patients with DM (adjusted OR = 2.304; 95% CI: 1.520-3.492; P<0.001), CVH (adjusted OR = 1.551; 95% CI: 1.053-2.285; P = 0.026) and chronic obstructive pulmonary diseases (COPD) (adjusted OR = 2.170; 95% CI: 1.215-3.872; P = 0.009) after adjusting for age, sex, delay from disease onset to admission and treatment regimens. When analyzing the comorbidities separately, we found that the high serum glucose could augment diseases severity. Compared to the group with max glucose < 7.0 mmol/L, patients with glucose between 7.0-11.1 mmol/L and glucose ≥11.1 mmol/L conferred higher death risk, with the adjusted OR to be 1.467 (95% CI: 1.081-1.989; P = 0.014) and 3.443 (95% CI: 2.427-4.884; P<0.001). Insulin therapy could effectively reduce the risk of severe outcome in DM patients with the adjusted OR 0.146 (95% CI: 0.058-0.365; P<0.001). For CVH patients, severe damage of liver and prolongation of blood coagulation time, as well as high prevalence of bleeding phenotype were observed. These data supported the provocative hypothesis that treating SFTS related complications can attain potentially beneficial effects on SFTS. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 13 5 e0007434 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Shao-Fei Zhang Zhen-Dong Yang Mao-Lin Huang Zhi-Bo Wang Yuan-Yuan Hu Dong Miao Ke Dai Juan Du Ning Cui Chun Yuan Hao Li Xiao-Kun Li Xiao-Ai Zhang Pan-He Zhang Xian-Miao Mi Qing-Bin Lu Wei Liu Preexisting chronic conditions for fatal outcome among SFTS patients: An observational Cohort Study. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that is caused by a novel bunyavirus SFTSV. Currently our knowledge of the host-related factors that influence the pathogenesis of disease is inadequate to allow prediction of fatal outcome. Here we conducted a prospective study of the largest database on the SFTS patients, to identify the presence of comorbidities in SFTS, and estimate their effect on the fatal outcome. Among 2096 patients eligible for inclusion, we identified nine kinds of comorbidities, from which hyperlipidemia (12.2%; 95% CI: 10.8%-13.6%), hypertension (11.0%; 95% CI: 9.6%-12.3%), chronic viral hepatitis (CVH) (9.3%; 95% CI: 8.1%-10.5%), and diabetes mellitus (DM) (6.8%; 95% CI: 5.7%-7.9%) were prevalent. Higher risk of death was found in patients with DM (adjusted OR = 2.304; 95% CI: 1.520-3.492; P<0.001), CVH (adjusted OR = 1.551; 95% CI: 1.053-2.285; P = 0.026) and chronic obstructive pulmonary diseases (COPD) (adjusted OR = 2.170; 95% CI: 1.215-3.872; P = 0.009) after adjusting for age, sex, delay from disease onset to admission and treatment regimens. When analyzing the comorbidities separately, we found that the high serum glucose could augment diseases severity. Compared to the group with max glucose < 7.0 mmol/L, patients with glucose between 7.0-11.1 mmol/L and glucose ≥11.1 mmol/L conferred higher death risk, with the adjusted OR to be 1.467 (95% CI: 1.081-1.989; P = 0.014) and 3.443 (95% CI: 2.427-4.884; P<0.001). Insulin therapy could effectively reduce the risk of severe outcome in DM patients with the adjusted OR 0.146 (95% CI: 0.058-0.365; P<0.001). For CVH patients, severe damage of liver and prolongation of blood coagulation time, as well as high prevalence of bleeding phenotype were observed. These data supported the provocative hypothesis that treating SFTS related complications can attain potentially beneficial effects on SFTS. |
format |
Article in Journal/Newspaper |
author |
Shao-Fei Zhang Zhen-Dong Yang Mao-Lin Huang Zhi-Bo Wang Yuan-Yuan Hu Dong Miao Ke Dai Juan Du Ning Cui Chun Yuan Hao Li Xiao-Kun Li Xiao-Ai Zhang Pan-He Zhang Xian-Miao Mi Qing-Bin Lu Wei Liu |
author_facet |
Shao-Fei Zhang Zhen-Dong Yang Mao-Lin Huang Zhi-Bo Wang Yuan-Yuan Hu Dong Miao Ke Dai Juan Du Ning Cui Chun Yuan Hao Li Xiao-Kun Li Xiao-Ai Zhang Pan-He Zhang Xian-Miao Mi Qing-Bin Lu Wei Liu |
author_sort |
Shao-Fei Zhang |
title |
Preexisting chronic conditions for fatal outcome among SFTS patients: An observational Cohort Study. |
title_short |
Preexisting chronic conditions for fatal outcome among SFTS patients: An observational Cohort Study. |
title_full |
Preexisting chronic conditions for fatal outcome among SFTS patients: An observational Cohort Study. |
title_fullStr |
Preexisting chronic conditions for fatal outcome among SFTS patients: An observational Cohort Study. |
title_full_unstemmed |
Preexisting chronic conditions for fatal outcome among SFTS patients: An observational Cohort Study. |
title_sort |
preexisting chronic conditions for fatal outcome among sfts patients: an observational cohort study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007434 https://doaj.org/article/a424264fec394feeb83cf30a60f41c27 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 5, p e0007434 (2019) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007434 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007434 https://doaj.org/article/a424264fec394feeb83cf30a60f41c27 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007434 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
13 |
container_issue |
5 |
container_start_page |
e0007434 |
_version_ |
1766346579685408768 |