Capillaria hepatica-induced hepatic fibrosis in rats: paradoxical effect of repeated infections
Multiple exposures to parasitic agents are considered an important factor in the genesis of the most severe forms of the diseases they cause. Capillaria hepatica-induced septal fibrosis of the liver in rats usually runs without signs of portal hypertension or hepatic failure. After determining the h...
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ftdoajarticles:oai:doaj.org/article:a3f7b48aa16a426db20051d2144692bc 2023-05-15T15:09:05+02:00 Capillaria hepatica-induced hepatic fibrosis in rats: paradoxical effect of repeated infections Ludmila Oliveira Márcia Maria de Souza Zilton A. Andrade 2004-03-01T00:00:00Z https://doaj.org/article/a3f7b48aa16a426db20051d2144692bc EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822004000200001&tlng=en https://doaj.org/toc/1678-9849 1678-9849 https://doaj.org/article/a3f7b48aa16a426db20051d2144692bc Revista da Sociedade Brasileira de Medicina Tropical, Vol 37, Iss 2, Pp 123-127 (2004) Capillaria hepatica Hepatic fibrosis Repeated infections Arctic medicine. Tropical medicine RC955-962 article 2004 ftdoajarticles 2022-12-31T03:21:25Z Multiple exposures to parasitic agents are considered an important factor in the genesis of the most severe forms of the diseases they cause. Capillaria hepatica-induced septal fibrosis of the liver in rats usually runs without signs of portal hypertension or hepatic failure. After determining the hepatic profile of 15 animals during the course of a single infection, we submitted 20 rats to multiple Capillaria hepatica infections to determine whether repeated exposures would augment fibrosis production, transforming septal hepatic fibrosis into a true cirrhosis. Ten single-infection rats served as controls. A total of 5 exposures, with 45-day intervals, were made. Histological changes were followed by means of surgical liver biopsies, collected prior to infection and to each re-infection. Functional changes were minimal and transient. Although a slight recrudescence of fibrosis was observed after the first two re-infections and when the single-infected control group was re-infected at the end of the experiment, subsequent re-infections failed to increase the amount of fibrosis. On the contrary, there occurred quantitative and qualitative evidence of collagen degradation and suppression of parasite development. These paradoxical results are in keeping with the hypothesis that a complex immunological modulation participates in the mechanism of hepatic fibrosis induced by Capillaria hepatica infection in rats. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Capillaria hepatica Hepatic fibrosis Repeated infections Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Capillaria hepatica Hepatic fibrosis Repeated infections Arctic medicine. Tropical medicine RC955-962 Ludmila Oliveira Márcia Maria de Souza Zilton A. Andrade Capillaria hepatica-induced hepatic fibrosis in rats: paradoxical effect of repeated infections |
topic_facet |
Capillaria hepatica Hepatic fibrosis Repeated infections Arctic medicine. Tropical medicine RC955-962 |
description |
Multiple exposures to parasitic agents are considered an important factor in the genesis of the most severe forms of the diseases they cause. Capillaria hepatica-induced septal fibrosis of the liver in rats usually runs without signs of portal hypertension or hepatic failure. After determining the hepatic profile of 15 animals during the course of a single infection, we submitted 20 rats to multiple Capillaria hepatica infections to determine whether repeated exposures would augment fibrosis production, transforming septal hepatic fibrosis into a true cirrhosis. Ten single-infection rats served as controls. A total of 5 exposures, with 45-day intervals, were made. Histological changes were followed by means of surgical liver biopsies, collected prior to infection and to each re-infection. Functional changes were minimal and transient. Although a slight recrudescence of fibrosis was observed after the first two re-infections and when the single-infected control group was re-infected at the end of the experiment, subsequent re-infections failed to increase the amount of fibrosis. On the contrary, there occurred quantitative and qualitative evidence of collagen degradation and suppression of parasite development. These paradoxical results are in keeping with the hypothesis that a complex immunological modulation participates in the mechanism of hepatic fibrosis induced by Capillaria hepatica infection in rats. |
format |
Article in Journal/Newspaper |
author |
Ludmila Oliveira Márcia Maria de Souza Zilton A. Andrade |
author_facet |
Ludmila Oliveira Márcia Maria de Souza Zilton A. Andrade |
author_sort |
Ludmila Oliveira |
title |
Capillaria hepatica-induced hepatic fibrosis in rats: paradoxical effect of repeated infections |
title_short |
Capillaria hepatica-induced hepatic fibrosis in rats: paradoxical effect of repeated infections |
title_full |
Capillaria hepatica-induced hepatic fibrosis in rats: paradoxical effect of repeated infections |
title_fullStr |
Capillaria hepatica-induced hepatic fibrosis in rats: paradoxical effect of repeated infections |
title_full_unstemmed |
Capillaria hepatica-induced hepatic fibrosis in rats: paradoxical effect of repeated infections |
title_sort |
capillaria hepatica-induced hepatic fibrosis in rats: paradoxical effect of repeated infections |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2004 |
url |
https://doaj.org/article/a3f7b48aa16a426db20051d2144692bc |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 37, Iss 2, Pp 123-127 (2004) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822004000200001&tlng=en https://doaj.org/toc/1678-9849 1678-9849 https://doaj.org/article/a3f7b48aa16a426db20051d2144692bc |
_version_ |
1766340323699589120 |