Secondary bacterial isolates from previously untreated Buruli ulcer lesions and their antibiotic susceptibility patterns in Southern Nigeria
Abstract INTRODUCTION: Mycolactones, secreted by Mycobacterium ulcerans, were previously believed to prevent super infection in Buruli ulcer lesions. However, little is known about secondary bacterial infections in these lesions. This study evaluated contaminating bacterial flora and their antibioti...
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ftdoajarticles:oai:doaj.org/article:a3f672310bc24554a07392b61b4900eb 2023-05-15T15:08:22+02:00 Secondary bacterial isolates from previously untreated Buruli ulcer lesions and their antibiotic susceptibility patterns in Southern Nigeria Moses Chibueze Anyim Anthony Obiamaka Meka Joseph Ngozi Chukwu Charles Chukwunalu Nwafor Daniel Chukwunweolu Oshi Nelson Okechukwu Madichie Ngozi Ekeke Chukwuka Alphonsus Obinna Mbah Chinenye Nwaekpe Martin Njoku Dare Fakiyesi Vitalis Ulodiaku Ignatius Ejiofor Adeniyi Hakeem Bisiriyu Kingsley Nnanna Ukwaja https://doi.org/10.1590/0037-8682-0404-2016 https://doaj.org/article/a3f672310bc24554a07392b61b4900eb EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822016000600746&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0404-2016 https://doaj.org/article/a3f672310bc24554a07392b61b4900eb Revista da Sociedade Brasileira de Medicina Tropical, Vol 49, Iss 6, Pp 746-751 Bacterial contamination Chemotherapy Mycobacterium ulcerans Mycolactones Wounds Arctic medicine. Tropical medicine RC955-962 article ftdoajarticles https://doi.org/10.1590/0037-8682-0404-2016 2022-12-30T21:27:50Z Abstract INTRODUCTION: Mycolactones, secreted by Mycobacterium ulcerans, were previously believed to prevent super infection in Buruli ulcer lesions. However, little is known about secondary bacterial infections in these lesions. This study evaluated contaminating bacterial flora and their antibiotic susceptibility patterns in cases of previously untreated Buruli ulcer disease from three states in Southern Nigeria. METHODS A prospective analysis was conducted between January and June of 2015 using wound swabs from eligible patients with Buruli ulcer disease, confirmed by quantitative-polymerase chain reaction, with active ulcers. Microbiological analyses including isolation of bacteria, species identification of isolates, and drug susceptibility tests were performed. RESULTS Of 51 patients, 27 (52.9%) were female. One or more bacterial species of clinical importance was isolated from each patient. A total of 17 different microbial species were isolated; 76.4% were Gram-negative and 23.6% were Gram-positive isolates. The most common bacterial species detected was Staphylococcus aureus (24%), followed by Aeromonas hydrophila (13%), Pseudomonas aeruginosa (13%), and Klebsiella pneumoniae (11%). Drug susceptibility tests showed a particularly high frequency of resistance to commonly used antimicrobials in Nigeria for Staphylococcus aureus. CONCLUSIONS Super bacterial infections occur in Buruli ulcer lesions in Nigeria, and these infections are associated with high rates of resistance to commonly used antibiotics in the country. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 49 6 746 751 |
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Bacterial contamination Chemotherapy Mycobacterium ulcerans Mycolactones Wounds Arctic medicine. Tropical medicine RC955-962 |
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Bacterial contamination Chemotherapy Mycobacterium ulcerans Mycolactones Wounds Arctic medicine. Tropical medicine RC955-962 Moses Chibueze Anyim Anthony Obiamaka Meka Joseph Ngozi Chukwu Charles Chukwunalu Nwafor Daniel Chukwunweolu Oshi Nelson Okechukwu Madichie Ngozi Ekeke Chukwuka Alphonsus Obinna Mbah Chinenye Nwaekpe Martin Njoku Dare Fakiyesi Vitalis Ulodiaku Ignatius Ejiofor Adeniyi Hakeem Bisiriyu Kingsley Nnanna Ukwaja Secondary bacterial isolates from previously untreated Buruli ulcer lesions and their antibiotic susceptibility patterns in Southern Nigeria |
topic_facet |
Bacterial contamination Chemotherapy Mycobacterium ulcerans Mycolactones Wounds Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract INTRODUCTION: Mycolactones, secreted by Mycobacterium ulcerans, were previously believed to prevent super infection in Buruli ulcer lesions. However, little is known about secondary bacterial infections in these lesions. This study evaluated contaminating bacterial flora and their antibiotic susceptibility patterns in cases of previously untreated Buruli ulcer disease from three states in Southern Nigeria. METHODS A prospective analysis was conducted between January and June of 2015 using wound swabs from eligible patients with Buruli ulcer disease, confirmed by quantitative-polymerase chain reaction, with active ulcers. Microbiological analyses including isolation of bacteria, species identification of isolates, and drug susceptibility tests were performed. RESULTS Of 51 patients, 27 (52.9%) were female. One or more bacterial species of clinical importance was isolated from each patient. A total of 17 different microbial species were isolated; 76.4% were Gram-negative and 23.6% were Gram-positive isolates. The most common bacterial species detected was Staphylococcus aureus (24%), followed by Aeromonas hydrophila (13%), Pseudomonas aeruginosa (13%), and Klebsiella pneumoniae (11%). Drug susceptibility tests showed a particularly high frequency of resistance to commonly used antimicrobials in Nigeria for Staphylococcus aureus. CONCLUSIONS Super bacterial infections occur in Buruli ulcer lesions in Nigeria, and these infections are associated with high rates of resistance to commonly used antibiotics in the country. |
format |
Article in Journal/Newspaper |
author |
Moses Chibueze Anyim Anthony Obiamaka Meka Joseph Ngozi Chukwu Charles Chukwunalu Nwafor Daniel Chukwunweolu Oshi Nelson Okechukwu Madichie Ngozi Ekeke Chukwuka Alphonsus Obinna Mbah Chinenye Nwaekpe Martin Njoku Dare Fakiyesi Vitalis Ulodiaku Ignatius Ejiofor Adeniyi Hakeem Bisiriyu Kingsley Nnanna Ukwaja |
author_facet |
Moses Chibueze Anyim Anthony Obiamaka Meka Joseph Ngozi Chukwu Charles Chukwunalu Nwafor Daniel Chukwunweolu Oshi Nelson Okechukwu Madichie Ngozi Ekeke Chukwuka Alphonsus Obinna Mbah Chinenye Nwaekpe Martin Njoku Dare Fakiyesi Vitalis Ulodiaku Ignatius Ejiofor Adeniyi Hakeem Bisiriyu Kingsley Nnanna Ukwaja |
author_sort |
Moses Chibueze Anyim |
title |
Secondary bacterial isolates from previously untreated Buruli ulcer lesions and their antibiotic susceptibility patterns in Southern Nigeria |
title_short |
Secondary bacterial isolates from previously untreated Buruli ulcer lesions and their antibiotic susceptibility patterns in Southern Nigeria |
title_full |
Secondary bacterial isolates from previously untreated Buruli ulcer lesions and their antibiotic susceptibility patterns in Southern Nigeria |
title_fullStr |
Secondary bacterial isolates from previously untreated Buruli ulcer lesions and their antibiotic susceptibility patterns in Southern Nigeria |
title_full_unstemmed |
Secondary bacterial isolates from previously untreated Buruli ulcer lesions and their antibiotic susceptibility patterns in Southern Nigeria |
title_sort |
secondary bacterial isolates from previously untreated buruli ulcer lesions and their antibiotic susceptibility patterns in southern nigeria |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
url |
https://doi.org/10.1590/0037-8682-0404-2016 https://doaj.org/article/a3f672310bc24554a07392b61b4900eb |
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Arctic |
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Arctic |
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Arctic |
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Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 49, Iss 6, Pp 746-751 |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822016000600746&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0404-2016 https://doaj.org/article/a3f672310bc24554a07392b61b4900eb |
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https://doi.org/10.1590/0037-8682-0404-2016 |
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