The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019
Abstract Background African Traditional Medicine (ATM) is used for the healthcare of about 80% of the rural populations of the continent of Africa. The practices of ATM make use of plant-products, which are known to contain plant-based secondary metabolites or natural products (NPs), likely to play...
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ftdoajarticles:oai:doaj.org/article:a3b33b72ed2e4b24985246a6d7312476 2023-05-15T15:17:30+02:00 The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019 Boris D. Bekono Fidele Ntie-Kang Pascal Amoa Onguéné Lydia L. Lifongo Wolfgang Sippl Karin Fester Luc C. O. Owono 2020-05-01T00:00:00Z https://doi.org/10.1186/s12936-020-03231-7 https://doaj.org/article/a3b33b72ed2e4b24985246a6d7312476 EN eng BMC http://link.springer.com/article/10.1186/s12936-020-03231-7 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-03231-7 1475-2875 https://doaj.org/article/a3b33b72ed2e4b24985246a6d7312476 Malaria Journal, Vol 19, Iss 1, Pp 1-35 (2020) Africa Malaria Medicinal plants Natural products Traditional medicine Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2020 ftdoajarticles https://doi.org/10.1186/s12936-020-03231-7 2023-01-08T01:34:32Z Abstract Background African Traditional Medicine (ATM) is used for the healthcare of about 80% of the rural populations of the continent of Africa. The practices of ATM make use of plant-products, which are known to contain plant-based secondary metabolites or natural products (NPs), likely to play key roles in drug discovery, particularly as lead compounds. For various reasons, including resistance of strains of Plasmodium to known anti-malarial drugs, local African populations often resort to plant-based treatments and/or a combination of this and standard anti-malarial regimens. Emphasis has been laid in this review to present the anti-malarial virtue of the most recently published phytochemicals or natural products, which have been tested by in vitro and in vivo assays. Methods The data was based on the current version of the African Compound Libraries, which are constantly being updated based on inputs from journal articles and student theses (M.Sc/Ph.D) from African University libraries. Emphasis was laid on data published after 2012. In order to carry out the original data collection, currently being included in the African Compounds Database, individual journal websites were queried using the country names in Africa as search terms. Over 40,000 articles “hits” were originally retrieved, then reduced to about 9000 articles. The retained articles/theses was further queried with the search terms “malaria”, “malarial”, “plasmodium”, “plasmodial” and a combination of them, resulting in over 500 articles. Those including compounds with anti-malarial activities for which the measured activities fell within the established cut off values numbered 55, which were all cited in the review as relevant references. Results and discussion Pure compounds derived from African medicinal plants with demonstrated anti-malarial/antiplasmodial properties with activities ranging from “very active” to “weakly active” have been discussed. The majority of the 187 natural products were terpenoids (30%), followed by flavonoids ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 19 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Africa Malaria Medicinal plants Natural products Traditional medicine Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Africa Malaria Medicinal plants Natural products Traditional medicine Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Boris D. Bekono Fidele Ntie-Kang Pascal Amoa Onguéné Lydia L. Lifongo Wolfgang Sippl Karin Fester Luc C. O. Owono The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019 |
topic_facet |
Africa Malaria Medicinal plants Natural products Traditional medicine Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background African Traditional Medicine (ATM) is used for the healthcare of about 80% of the rural populations of the continent of Africa. The practices of ATM make use of plant-products, which are known to contain plant-based secondary metabolites or natural products (NPs), likely to play key roles in drug discovery, particularly as lead compounds. For various reasons, including resistance of strains of Plasmodium to known anti-malarial drugs, local African populations often resort to plant-based treatments and/or a combination of this and standard anti-malarial regimens. Emphasis has been laid in this review to present the anti-malarial virtue of the most recently published phytochemicals or natural products, which have been tested by in vitro and in vivo assays. Methods The data was based on the current version of the African Compound Libraries, which are constantly being updated based on inputs from journal articles and student theses (M.Sc/Ph.D) from African University libraries. Emphasis was laid on data published after 2012. In order to carry out the original data collection, currently being included in the African Compounds Database, individual journal websites were queried using the country names in Africa as search terms. Over 40,000 articles “hits” were originally retrieved, then reduced to about 9000 articles. The retained articles/theses was further queried with the search terms “malaria”, “malarial”, “plasmodium”, “plasmodial” and a combination of them, resulting in over 500 articles. Those including compounds with anti-malarial activities for which the measured activities fell within the established cut off values numbered 55, which were all cited in the review as relevant references. Results and discussion Pure compounds derived from African medicinal plants with demonstrated anti-malarial/antiplasmodial properties with activities ranging from “very active” to “weakly active” have been discussed. The majority of the 187 natural products were terpenoids (30%), followed by flavonoids ... |
format |
Article in Journal/Newspaper |
author |
Boris D. Bekono Fidele Ntie-Kang Pascal Amoa Onguéné Lydia L. Lifongo Wolfgang Sippl Karin Fester Luc C. O. Owono |
author_facet |
Boris D. Bekono Fidele Ntie-Kang Pascal Amoa Onguéné Lydia L. Lifongo Wolfgang Sippl Karin Fester Luc C. O. Owono |
author_sort |
Boris D. Bekono |
title |
The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019 |
title_short |
The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019 |
title_full |
The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019 |
title_fullStr |
The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019 |
title_full_unstemmed |
The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019 |
title_sort |
potential of anti-malarial compounds derived from african medicinal plants: a review of pharmacological evaluations from 2013 to 2019 |
publisher |
BMC |
publishDate |
2020 |
url |
https://doi.org/10.1186/s12936-020-03231-7 https://doaj.org/article/a3b33b72ed2e4b24985246a6d7312476 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 19, Iss 1, Pp 1-35 (2020) |
op_relation |
http://link.springer.com/article/10.1186/s12936-020-03231-7 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-03231-7 1475-2875 https://doaj.org/article/a3b33b72ed2e4b24985246a6d7312476 |
op_doi |
https://doi.org/10.1186/s12936-020-03231-7 |
container_title |
Malaria Journal |
container_volume |
19 |
container_issue |
1 |
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1766347735957504000 |