Acute hypotensive and diuretic activities of Artemisia herba alba aqueous extract in normal rats
Objective: To evaluate the effect of Artemisia herba alba (A. herba alba) intravenous injection on cardiovascular and renal function in normal rats. Methods: The effect of intravenous injection of A. herba alba extract at the different doses of 50, 100 and 200 mg/kg was investigated in normal rats....
Published in: | Asian Pacific Journal of Tropical Biomedicine |
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Wolters Kluwer Medknow Publications
2014
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ftdoajarticles:oai:doaj.org/article:a388555fb45b423599131d69ea1f214e 2023-05-15T15:09:59+02:00 Acute hypotensive and diuretic activities of Artemisia herba alba aqueous extract in normal rats Naoufel Ali Zeggwagh Jean Baptiste Michel Mohamed Eddouks 2014-07-01T00:00:00Z https://doi.org/10.12980/APJTB.4.2014APJTB-2014-0136 https://doaj.org/article/a388555fb45b423599131d69ea1f214e EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115300642 https://doaj.org/toc/2221-1691 2221-1691 doi:10.12980/APJTB.4.2014APJTB-2014-0136 https://doaj.org/article/a388555fb45b423599131d69ea1f214e Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss S2, Pp S644-S648 (2014) Ethnopharmacology Mean arterial pressure Urine output Urine electrolytes Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2014 ftdoajarticles https://doi.org/10.12980/APJTB.4.2014APJTB-2014-0136 2022-12-31T14:09:00Z Objective: To evaluate the effect of Artemisia herba alba (A. herba alba) intravenous injection on cardiovascular and renal function in normal rats. Methods: The effect of intravenous injection of A. herba alba extract at the different doses of 50, 100 and 200 mg/kg was investigated in normal rats. Diuresis, heart frequency and electrolytes concentrations were analyzed. Results: Intravenous bolus injection of A. herba alba at the different doses of 50, 100 and 200 mg/kg produced a dose dependent reduction in arterial blood pressure (P<0.001). A significant reduction in heart frequency was observed after A. herba alba injection at the doses of 100 and 200 mg/kg (P<0.001). Perfusion of aqueous A. herba alba extract at a dose of 200 mg/(kg·h) caused a significant increase in urine output after 4 h of perfusion (P<0.001). In addition, a significant increase in urinary sodium and potassium excretion was observed from the first (P<0.05) to the fourth hour (P<0.001) of A. herba alba perfusion. Urinary chlorure excretion increased after 2 h of perfusion (P<0.001). However, glomerular filtration rate remained unchanged after A. herba alba perfusion (P<0.05). Conclusions: We conclude that the aqueous A. herba alba extract possesses a potent acute hypotensive effect on normal rats. In addition, A. herba alba perfusion may affect renal function to increase urine and electrolytes excretion. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 4 S644 S648 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Ethnopharmacology Mean arterial pressure Urine output Urine electrolytes Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Ethnopharmacology Mean arterial pressure Urine output Urine electrolytes Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Naoufel Ali Zeggwagh Jean Baptiste Michel Mohamed Eddouks Acute hypotensive and diuretic activities of Artemisia herba alba aqueous extract in normal rats |
topic_facet |
Ethnopharmacology Mean arterial pressure Urine output Urine electrolytes Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To evaluate the effect of Artemisia herba alba (A. herba alba) intravenous injection on cardiovascular and renal function in normal rats. Methods: The effect of intravenous injection of A. herba alba extract at the different doses of 50, 100 and 200 mg/kg was investigated in normal rats. Diuresis, heart frequency and electrolytes concentrations were analyzed. Results: Intravenous bolus injection of A. herba alba at the different doses of 50, 100 and 200 mg/kg produced a dose dependent reduction in arterial blood pressure (P<0.001). A significant reduction in heart frequency was observed after A. herba alba injection at the doses of 100 and 200 mg/kg (P<0.001). Perfusion of aqueous A. herba alba extract at a dose of 200 mg/(kg·h) caused a significant increase in urine output after 4 h of perfusion (P<0.001). In addition, a significant increase in urinary sodium and potassium excretion was observed from the first (P<0.05) to the fourth hour (P<0.001) of A. herba alba perfusion. Urinary chlorure excretion increased after 2 h of perfusion (P<0.001). However, glomerular filtration rate remained unchanged after A. herba alba perfusion (P<0.05). Conclusions: We conclude that the aqueous A. herba alba extract possesses a potent acute hypotensive effect on normal rats. In addition, A. herba alba perfusion may affect renal function to increase urine and electrolytes excretion. |
format |
Article in Journal/Newspaper |
author |
Naoufel Ali Zeggwagh Jean Baptiste Michel Mohamed Eddouks |
author_facet |
Naoufel Ali Zeggwagh Jean Baptiste Michel Mohamed Eddouks |
author_sort |
Naoufel Ali Zeggwagh |
title |
Acute hypotensive and diuretic activities of Artemisia herba alba aqueous extract in normal rats |
title_short |
Acute hypotensive and diuretic activities of Artemisia herba alba aqueous extract in normal rats |
title_full |
Acute hypotensive and diuretic activities of Artemisia herba alba aqueous extract in normal rats |
title_fullStr |
Acute hypotensive and diuretic activities of Artemisia herba alba aqueous extract in normal rats |
title_full_unstemmed |
Acute hypotensive and diuretic activities of Artemisia herba alba aqueous extract in normal rats |
title_sort |
acute hypotensive and diuretic activities of artemisia herba alba aqueous extract in normal rats |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2014 |
url |
https://doi.org/10.12980/APJTB.4.2014APJTB-2014-0136 https://doaj.org/article/a388555fb45b423599131d69ea1f214e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss S2, Pp S644-S648 (2014) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115300642 https://doaj.org/toc/2221-1691 2221-1691 doi:10.12980/APJTB.4.2014APJTB-2014-0136 https://doaj.org/article/a388555fb45b423599131d69ea1f214e |
op_doi |
https://doi.org/10.12980/APJTB.4.2014APJTB-2014-0136 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
4 |
container_start_page |
S644 |
op_container_end_page |
S648 |
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1766341064348663808 |