The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing Fasciitis of the Leg: Early Clinical Experience and Literature Review on Indications for Intact Fish Skin Grafts
Background: Necrotizing fasciitis (NF) is a serious infectious disease that can initially place the patient’s life in danger and, after successful surgical and antibiotic treatment, leaves extensive wounds with sometimes even exposed bones and tendons. Autologous skin grafts are not always possible...
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MDPI AG
2023
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Online Access: | https://doi.org/10.3390/jcm12186001 https://doaj.org/article/a36a5dc0641e4f97890783eea7693b54 |
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ftdoajarticles:oai:doaj.org/article:a36a5dc0641e4f97890783eea7693b54 2023-10-29T02:37:27+01:00 The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing Fasciitis of the Leg: Early Clinical Experience and Literature Review on Indications for Intact Fish Skin Grafts Philip Dueppers Roland Bozalka Reinhard Kopp Anna-Leonie Menges Benedikt Reutersberg Claudia Schrimpf Francisco Jose Moreno Rivero Alexander Zimmermann 2023-09-01T00:00:00Z https://doi.org/10.3390/jcm12186001 https://doaj.org/article/a36a5dc0641e4f97890783eea7693b54 EN eng MDPI AG https://www.mdpi.com/2077-0383/12/18/6001 https://doaj.org/toc/2077-0383 doi:10.3390/jcm12186001 2077-0383 https://doaj.org/article/a36a5dc0641e4f97890783eea7693b54 Journal of Clinical Medicine, Vol 12, Iss 6001, p 6001 (2023) intact fish skin fish skin grafts necrotizing fasciitis wounds chronic wounds gangrene Medicine R article 2023 ftdoajarticles https://doi.org/10.3390/jcm12186001 2023-10-01T00:38:00Z Background: Necrotizing fasciitis (NF) is a serious infectious disease that can initially place the patient’s life in danger and, after successful surgical and antibiotic treatment, leaves extensive wounds with sometimes even exposed bones and tendons. Autologous skin grafts are not always possible or require adequate wound bed preparation. Novel intact fish skin grafts (iFSGs; Kerecis ® Omega3 Wound, Kerecis hf, Isafjördur, Iceland) have already shown their potential to promote granulation in many other wound situations. Faster wound healing rates and better functional and cosmetic outcomes were observed due to their additionally postulated anti-inflammatory and analgesic properties. Therefore, iFSGs may also be essential in treating NF. We present our initial experience with iFSGs in treating leg wounds after NF and review the literature for the current spectrum of clinical use of iFSGs. Case Presentations: We present two male patients (aged 60 and 69 years) with chronic or acute postsurgical extensive leg ulcers six weeks and six days after necrotizing fasciitis, respectively. Both suffered from diabetes mellitus without vascular pathologies of the lower limbs. A single application of one pre-meshed (Kerecis ® Graftguide) and one self-meshed 300 cm 2 iFSG (Kerecis ® Surgiclose) was performed in our operation room after extensive surgical debridement and single circles of negative wound pressure therapy. Application and handling were easy. An excellent wound granulation was observed, even in uncovered tibia bone and tendons, accompanied by pain relief in both patients. Neither complications nor allergic reactions occurred. The patients received autologous skin grafting with excellent functional and cosmetic outcomes. Conclusions: iFSGs have the potential to play a significant role in the future treatment of NF due to the fast promotion of wound granulation and pain relief. Our experience may encourage surgeons to use iFSGs in NF patients, although high-quality, large-sized studies are still required to confirm ... Article in Journal/Newspaper Iceland Directory of Open Access Journals: DOAJ Articles Journal of Clinical Medicine 12 18 6001 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
intact fish skin fish skin grafts necrotizing fasciitis wounds chronic wounds gangrene Medicine R |
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intact fish skin fish skin grafts necrotizing fasciitis wounds chronic wounds gangrene Medicine R Philip Dueppers Roland Bozalka Reinhard Kopp Anna-Leonie Menges Benedikt Reutersberg Claudia Schrimpf Francisco Jose Moreno Rivero Alexander Zimmermann The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing Fasciitis of the Leg: Early Clinical Experience and Literature Review on Indications for Intact Fish Skin Grafts |
topic_facet |
intact fish skin fish skin grafts necrotizing fasciitis wounds chronic wounds gangrene Medicine R |
description |
Background: Necrotizing fasciitis (NF) is a serious infectious disease that can initially place the patient’s life in danger and, after successful surgical and antibiotic treatment, leaves extensive wounds with sometimes even exposed bones and tendons. Autologous skin grafts are not always possible or require adequate wound bed preparation. Novel intact fish skin grafts (iFSGs; Kerecis ® Omega3 Wound, Kerecis hf, Isafjördur, Iceland) have already shown their potential to promote granulation in many other wound situations. Faster wound healing rates and better functional and cosmetic outcomes were observed due to their additionally postulated anti-inflammatory and analgesic properties. Therefore, iFSGs may also be essential in treating NF. We present our initial experience with iFSGs in treating leg wounds after NF and review the literature for the current spectrum of clinical use of iFSGs. Case Presentations: We present two male patients (aged 60 and 69 years) with chronic or acute postsurgical extensive leg ulcers six weeks and six days after necrotizing fasciitis, respectively. Both suffered from diabetes mellitus without vascular pathologies of the lower limbs. A single application of one pre-meshed (Kerecis ® Graftguide) and one self-meshed 300 cm 2 iFSG (Kerecis ® Surgiclose) was performed in our operation room after extensive surgical debridement and single circles of negative wound pressure therapy. Application and handling were easy. An excellent wound granulation was observed, even in uncovered tibia bone and tendons, accompanied by pain relief in both patients. Neither complications nor allergic reactions occurred. The patients received autologous skin grafting with excellent functional and cosmetic outcomes. Conclusions: iFSGs have the potential to play a significant role in the future treatment of NF due to the fast promotion of wound granulation and pain relief. Our experience may encourage surgeons to use iFSGs in NF patients, although high-quality, large-sized studies are still required to confirm ... |
format |
Article in Journal/Newspaper |
author |
Philip Dueppers Roland Bozalka Reinhard Kopp Anna-Leonie Menges Benedikt Reutersberg Claudia Schrimpf Francisco Jose Moreno Rivero Alexander Zimmermann |
author_facet |
Philip Dueppers Roland Bozalka Reinhard Kopp Anna-Leonie Menges Benedikt Reutersberg Claudia Schrimpf Francisco Jose Moreno Rivero Alexander Zimmermann |
author_sort |
Philip Dueppers |
title |
The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing Fasciitis of the Leg: Early Clinical Experience and Literature Review on Indications for Intact Fish Skin Grafts |
title_short |
The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing Fasciitis of the Leg: Early Clinical Experience and Literature Review on Indications for Intact Fish Skin Grafts |
title_full |
The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing Fasciitis of the Leg: Early Clinical Experience and Literature Review on Indications for Intact Fish Skin Grafts |
title_fullStr |
The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing Fasciitis of the Leg: Early Clinical Experience and Literature Review on Indications for Intact Fish Skin Grafts |
title_full_unstemmed |
The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing Fasciitis of the Leg: Early Clinical Experience and Literature Review on Indications for Intact Fish Skin Grafts |
title_sort |
use of intact fish skin grafts in the treatment of necrotizing fasciitis of the leg: early clinical experience and literature review on indications for intact fish skin grafts |
publisher |
MDPI AG |
publishDate |
2023 |
url |
https://doi.org/10.3390/jcm12186001 https://doaj.org/article/a36a5dc0641e4f97890783eea7693b54 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Journal of Clinical Medicine, Vol 12, Iss 6001, p 6001 (2023) |
op_relation |
https://www.mdpi.com/2077-0383/12/18/6001 https://doaj.org/toc/2077-0383 doi:10.3390/jcm12186001 2077-0383 https://doaj.org/article/a36a5dc0641e4f97890783eea7693b54 |
op_doi |
https://doi.org/10.3390/jcm12186001 |
container_title |
Journal of Clinical Medicine |
container_volume |
12 |
container_issue |
18 |
container_start_page |
6001 |
_version_ |
1781062217158885376 |