Copeptin does not accurately predict disease severity in imported malaria
Abstract Background Copeptin has recently been identified to be a stable surrogate marker for the unstable hormone arginine vasopressin (AVP). Copeptin has been shown to correlate with disease severity in leptospirosis and bacterial sepsis. Hyponatraemia is common in severe imported malaria and dysr...
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ftdoajarticles:oai:doaj.org/article:a3449e63909f4119b7ba310e90db916d 2023-05-15T15:11:16+02:00 Copeptin does not accurately predict disease severity in imported malaria van Wolfswinkel Marlies E Hesselink Dennis A Hoorn Ewout J de Rijke Yolanda B Koelewijn Rob van Hellemond Jaap J van Genderen Perry JJ 2012-01-01T00:00:00Z https://doi.org/10.1186/1475-2875-11-6 https://doaj.org/article/a3449e63909f4119b7ba310e90db916d EN eng BMC http://www.malariajournal.com/content/11/1/6 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-6 1475-2875 https://doaj.org/article/a3449e63909f4119b7ba310e90db916d Malaria Journal, Vol 11, Iss 1, p 6 (2012) Malaria Imported Severity Biomarkers Copeptin Arginine vasopressin C-reactive protein CRP Traveller Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2012 ftdoajarticles https://doi.org/10.1186/1475-2875-11-6 2022-12-31T12:09:54Z Abstract Background Copeptin has recently been identified to be a stable surrogate marker for the unstable hormone arginine vasopressin (AVP). Copeptin has been shown to correlate with disease severity in leptospirosis and bacterial sepsis. Hyponatraemia is common in severe imported malaria and dysregulation of AVP release has been hypothesized as an underlying pathophysiological mechanism. The aim of the present study was to evaluate the performance of copeptin as a predictor of disease severity in imported malaria. Methods Copeptin was measured in stored serum samples of 204 patients with imported malaria that were admitted to our Institute for Tropical Diseases in Rotterdam in the period 1999-2010. The occurrence of WHO defined severe malaria was the primary end-point. The diagnostic performance of copeptin was compared to that of previously evaluated biomarkers C-reactive protein, procalcitonin, lactate and sodium. Results Of the 204 patients (141 Plasmodium falciparum , 63 non-falciparum infection), 25 had severe malaria. The Area Under the ROC curve of copeptin for severe disease (0.66 [95% confidence interval 0.59-0.72]) was comparable to that of lactate, sodium and procalcitonin. C-reactive protein (0.84 [95% CI 0.79-0.89]) had a significantly better performance as a biomarker for severe malaria than the other biomarkers. Conclusions C-reactive protein but not copeptin was found to be an accurate predictor for disease severity in imported malaria. The applicability of copeptin as a marker for severe malaria in clinical practice is limited to exclusion of severe malaria. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Traveller ENVELOPE(-48.533,-48.533,61.133,61.133) Malaria Journal 11 1 6 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Malaria Imported Severity Biomarkers Copeptin Arginine vasopressin C-reactive protein CRP Traveller Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria Imported Severity Biomarkers Copeptin Arginine vasopressin C-reactive protein CRP Traveller Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 van Wolfswinkel Marlies E Hesselink Dennis A Hoorn Ewout J de Rijke Yolanda B Koelewijn Rob van Hellemond Jaap J van Genderen Perry JJ Copeptin does not accurately predict disease severity in imported malaria |
topic_facet |
Malaria Imported Severity Biomarkers Copeptin Arginine vasopressin C-reactive protein CRP Traveller Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Copeptin has recently been identified to be a stable surrogate marker for the unstable hormone arginine vasopressin (AVP). Copeptin has been shown to correlate with disease severity in leptospirosis and bacterial sepsis. Hyponatraemia is common in severe imported malaria and dysregulation of AVP release has been hypothesized as an underlying pathophysiological mechanism. The aim of the present study was to evaluate the performance of copeptin as a predictor of disease severity in imported malaria. Methods Copeptin was measured in stored serum samples of 204 patients with imported malaria that were admitted to our Institute for Tropical Diseases in Rotterdam in the period 1999-2010. The occurrence of WHO defined severe malaria was the primary end-point. The diagnostic performance of copeptin was compared to that of previously evaluated biomarkers C-reactive protein, procalcitonin, lactate and sodium. Results Of the 204 patients (141 Plasmodium falciparum , 63 non-falciparum infection), 25 had severe malaria. The Area Under the ROC curve of copeptin for severe disease (0.66 [95% confidence interval 0.59-0.72]) was comparable to that of lactate, sodium and procalcitonin. C-reactive protein (0.84 [95% CI 0.79-0.89]) had a significantly better performance as a biomarker for severe malaria than the other biomarkers. Conclusions C-reactive protein but not copeptin was found to be an accurate predictor for disease severity in imported malaria. The applicability of copeptin as a marker for severe malaria in clinical practice is limited to exclusion of severe malaria. |
format |
Article in Journal/Newspaper |
author |
van Wolfswinkel Marlies E Hesselink Dennis A Hoorn Ewout J de Rijke Yolanda B Koelewijn Rob van Hellemond Jaap J van Genderen Perry JJ |
author_facet |
van Wolfswinkel Marlies E Hesselink Dennis A Hoorn Ewout J de Rijke Yolanda B Koelewijn Rob van Hellemond Jaap J van Genderen Perry JJ |
author_sort |
van Wolfswinkel Marlies E |
title |
Copeptin does not accurately predict disease severity in imported malaria |
title_short |
Copeptin does not accurately predict disease severity in imported malaria |
title_full |
Copeptin does not accurately predict disease severity in imported malaria |
title_fullStr |
Copeptin does not accurately predict disease severity in imported malaria |
title_full_unstemmed |
Copeptin does not accurately predict disease severity in imported malaria |
title_sort |
copeptin does not accurately predict disease severity in imported malaria |
publisher |
BMC |
publishDate |
2012 |
url |
https://doi.org/10.1186/1475-2875-11-6 https://doaj.org/article/a3449e63909f4119b7ba310e90db916d |
long_lat |
ENVELOPE(-48.533,-48.533,61.133,61.133) |
geographic |
Arctic Traveller |
geographic_facet |
Arctic Traveller |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 11, Iss 1, p 6 (2012) |
op_relation |
http://www.malariajournal.com/content/11/1/6 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-6 1475-2875 https://doaj.org/article/a3449e63909f4119b7ba310e90db916d |
op_doi |
https://doi.org/10.1186/1475-2875-11-6 |
container_title |
Malaria Journal |
container_volume |
11 |
container_issue |
1 |
container_start_page |
6 |
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1766342153230876672 |