Design and methods of the Ludwig-McGill longitudinal study of the natural history of human papillomavirus infection and cervical neoplasia in Brazil
This article reports on a large longitudinal study, begun in 1993, of the natural history of human papillomavirus (HPV) infection and cervical neoplasia in a population of low-income women in São Paulo, Brazil, a city with one of the highest risks worldwide for cervical cancer. Known as the Ludwig-M...
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ftdoajarticles:oai:doaj.org/article:a31d484703df4d51891ec0393e5c1718 2023-05-15T15:14:37+02:00 Design and methods of the Ludwig-McGill longitudinal study of the natural history of human papillomavirus infection and cervical neoplasia in Brazil Eduardo Franco Luisa Villa Thomas Rohan Alex Ferenczy Maria Petzl-Erler Greg Matlashewski 1999-10-01T00:00:00Z https://doi.org/10.1590/s1020-49891999000900001 https://doaj.org/article/a31d484703df4d51891ec0393e5c1718 EN ES PT eng spa por Pan American Health Organization http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49891999000900001&lng=en&tlng=en https://doaj.org/toc/1020-4989 1020-4989 doi:10.1590/s1020-49891999000900001 https://doaj.org/article/a31d484703df4d51891ec0393e5c1718 Revista Panamericana de Salud Pública, Vol 6, Iss 4, Pp 223-233 (1999) Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 1999 ftdoajarticles https://doi.org/10.1590/s1020-49891999000900001 2022-12-31T16:25:22Z This article reports on a large longitudinal study, begun in 1993, of the natural history of human papillomavirus (HPV) infection and cervical neoplasia in a population of low-income women in São Paulo, Brazil, a city with one of the highest risks worldwide for cervical cancer. Known as the Ludwig-McGill cohort study, the epidemiological investigation focuses on persistent infection with oncogenic HPV types as the precursor event leading to cervical neoplasia. The objectives of this study are to: 1) study the epidemiology of persistent cervical HPV infection in asymptomatic women, 2) investigate whether persistent HPV infection increases risk of low-grade and high-grade cervical lesions, 3) search for determinants of persistent HPV infection, 4) search for molecular variants of HPV that may be associated with an increased risk of lesions, 5) investigate whether viral burden is correlated with persistent infections and with lesion risk, 6) study the antibody response to HPV as a predictor of persistence and lesion progression, and 7) examine the role of HLA typing and codon 72 p53 gene polymorphism in mediating HPV persistence and lesion severity. The study accrued 2 528 female subjects through March 1997. Subjects were followed up every 4 months in the first year, with twice-yearly return visits to take place in subsequent years. Participants undergo a questionnaire-based interview, have a cervical specimen taken for Pap cytology and HPV testing, and have a blood sample drawn for HPV antibody testing. A cervicography is performed once in the first year and every two years thereafter. In this article we describe the design and methods of the study, provide baseline cohort characteristics, and present a preliminary assessment of the prognostic value of baseline HPV status. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista Panamericana de Salud Pública 6 4 223 233 |
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English Spanish Portuguese |
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Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Eduardo Franco Luisa Villa Thomas Rohan Alex Ferenczy Maria Petzl-Erler Greg Matlashewski Design and methods of the Ludwig-McGill longitudinal study of the natural history of human papillomavirus infection and cervical neoplasia in Brazil |
topic_facet |
Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
This article reports on a large longitudinal study, begun in 1993, of the natural history of human papillomavirus (HPV) infection and cervical neoplasia in a population of low-income women in São Paulo, Brazil, a city with one of the highest risks worldwide for cervical cancer. Known as the Ludwig-McGill cohort study, the epidemiological investigation focuses on persistent infection with oncogenic HPV types as the precursor event leading to cervical neoplasia. The objectives of this study are to: 1) study the epidemiology of persistent cervical HPV infection in asymptomatic women, 2) investigate whether persistent HPV infection increases risk of low-grade and high-grade cervical lesions, 3) search for determinants of persistent HPV infection, 4) search for molecular variants of HPV that may be associated with an increased risk of lesions, 5) investigate whether viral burden is correlated with persistent infections and with lesion risk, 6) study the antibody response to HPV as a predictor of persistence and lesion progression, and 7) examine the role of HLA typing and codon 72 p53 gene polymorphism in mediating HPV persistence and lesion severity. The study accrued 2 528 female subjects through March 1997. Subjects were followed up every 4 months in the first year, with twice-yearly return visits to take place in subsequent years. Participants undergo a questionnaire-based interview, have a cervical specimen taken for Pap cytology and HPV testing, and have a blood sample drawn for HPV antibody testing. A cervicography is performed once in the first year and every two years thereafter. In this article we describe the design and methods of the study, provide baseline cohort characteristics, and present a preliminary assessment of the prognostic value of baseline HPV status. |
format |
Article in Journal/Newspaper |
author |
Eduardo Franco Luisa Villa Thomas Rohan Alex Ferenczy Maria Petzl-Erler Greg Matlashewski |
author_facet |
Eduardo Franco Luisa Villa Thomas Rohan Alex Ferenczy Maria Petzl-Erler Greg Matlashewski |
author_sort |
Eduardo Franco |
title |
Design and methods of the Ludwig-McGill longitudinal study of the natural history of human papillomavirus infection and cervical neoplasia in Brazil |
title_short |
Design and methods of the Ludwig-McGill longitudinal study of the natural history of human papillomavirus infection and cervical neoplasia in Brazil |
title_full |
Design and methods of the Ludwig-McGill longitudinal study of the natural history of human papillomavirus infection and cervical neoplasia in Brazil |
title_fullStr |
Design and methods of the Ludwig-McGill longitudinal study of the natural history of human papillomavirus infection and cervical neoplasia in Brazil |
title_full_unstemmed |
Design and methods of the Ludwig-McGill longitudinal study of the natural history of human papillomavirus infection and cervical neoplasia in Brazil |
title_sort |
design and methods of the ludwig-mcgill longitudinal study of the natural history of human papillomavirus infection and cervical neoplasia in brazil |
publisher |
Pan American Health Organization |
publishDate |
1999 |
url |
https://doi.org/10.1590/s1020-49891999000900001 https://doaj.org/article/a31d484703df4d51891ec0393e5c1718 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 6, Iss 4, Pp 223-233 (1999) |
op_relation |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49891999000900001&lng=en&tlng=en https://doaj.org/toc/1020-4989 1020-4989 doi:10.1590/s1020-49891999000900001 https://doaj.org/article/a31d484703df4d51891ec0393e5c1718 |
op_doi |
https://doi.org/10.1590/s1020-49891999000900001 |
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Revista Panamericana de Salud Pública |
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6 |
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223 |
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233 |
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