Evaluation of the mitigation efficacy of a yeast cell wall extract toward deoxynivalenol contaminated diet fed to turbot (Scophthalmus maximus)
Deoxynivalenol (DON) is one of the most common mycotoxins in animal feed worldwide and causes significant threats to the animal health. Increased use of plant ingredients in aquaculture feeds increased the risk of mycotoxin contamination. To evaluate the effects of dietary deoxynivalenol (DON) on gr...
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ftdoajarticles:oai:doaj.org/article:a2e8d352c2be441caf2cdd463886842d 2023-05-15T18:15:52+02:00 Evaluation of the mitigation efficacy of a yeast cell wall extract toward deoxynivalenol contaminated diet fed to turbot (Scophthalmus maximus) Tiantian Wang Jinzhu Yang Gang Lin Mingzhu Li Ronghua Zhu Alexandros Yiannikouris Ruiguo Wang Yanjiao Zhang Kangsen Mai 2021-06-01T00:00:00Z https://doi.org/10.1016/j.ecoenv.2021.112221 https://doaj.org/article/a2e8d352c2be441caf2cdd463886842d EN eng Elsevier http://www.sciencedirect.com/science/article/pii/S0147651321003328 https://doaj.org/toc/0147-6513 0147-6513 doi:10.1016/j.ecoenv.2021.112221 https://doaj.org/article/a2e8d352c2be441caf2cdd463886842d Ecotoxicology and Environmental Safety, Vol 216, Iss , Pp 112221- (2021) Deoxynivalenol Yeast cell wall extract Growth performance Immune response Intestinal health Turbot Environmental pollution TD172-193.5 Environmental sciences GE1-350 article 2021 ftdoajarticles https://doi.org/10.1016/j.ecoenv.2021.112221 2022-12-31T10:45:22Z Deoxynivalenol (DON) is one of the most common mycotoxins in animal feed worldwide and causes significant threats to the animal health. Increased use of plant ingredients in aquaculture feeds increased the risk of mycotoxin contamination. To evaluate the effects of dietary deoxynivalenol (DON) on growth performance, immune response and intestinal health of turbot and the mitigation efficacy of yeast cell wall extract (YCWE) toward DON, nine isonitrogenous and isolipidic diets were formulated: Diet 1 (control): No DON added; Diets 2–5 or Diets 6–9: 0.5 or 3.0 mg added DON/kg diet + 0%, 0.1%, 0.2%, or 0.4% YCWE, respectively. Results showed that Diet 6 (3 mg/kg DON, 0% YCWE) significantly decreased weight gain, specific growth rate and feed efficiency ratio of fish and reduced immunoglobulin M and complement 4 concentrations in serum. Fish fed Diet 6 presented morphological alterations, lower activity of superoxide dismutase, catalase and total antioxidant capacity but higher malondialdehyde content, lower claudin-4 and occludin expression but higher interleukin-1β expression in intestine. Besides, Diet 6 decreased the abundance of potential helpful bacteria but increased the abundance of potential pathogens in intestine. While, dietary YCWE, especially Diet 8 (3 mg/kg DON, 0.2% YCWE) and 9 (3 mg/kg DON, 0.4% YCWE), markedly improved growth performance and immune response and enhanced the intestinal health of turbot. In conclusion, dietary YCWE could mitigate the toxic effects induced by DON in turbot, and could be used as an effective strategy to control DON contamination in fish feed. Article in Journal/Newspaper Scophthalmus maximus Turbot Directory of Open Access Journals: DOAJ Articles Ecotoxicology and Environmental Safety 216 112221 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Deoxynivalenol Yeast cell wall extract Growth performance Immune response Intestinal health Turbot Environmental pollution TD172-193.5 Environmental sciences GE1-350 |
spellingShingle |
Deoxynivalenol Yeast cell wall extract Growth performance Immune response Intestinal health Turbot Environmental pollution TD172-193.5 Environmental sciences GE1-350 Tiantian Wang Jinzhu Yang Gang Lin Mingzhu Li Ronghua Zhu Alexandros Yiannikouris Ruiguo Wang Yanjiao Zhang Kangsen Mai Evaluation of the mitigation efficacy of a yeast cell wall extract toward deoxynivalenol contaminated diet fed to turbot (Scophthalmus maximus) |
topic_facet |
Deoxynivalenol Yeast cell wall extract Growth performance Immune response Intestinal health Turbot Environmental pollution TD172-193.5 Environmental sciences GE1-350 |
description |
Deoxynivalenol (DON) is one of the most common mycotoxins in animal feed worldwide and causes significant threats to the animal health. Increased use of plant ingredients in aquaculture feeds increased the risk of mycotoxin contamination. To evaluate the effects of dietary deoxynivalenol (DON) on growth performance, immune response and intestinal health of turbot and the mitigation efficacy of yeast cell wall extract (YCWE) toward DON, nine isonitrogenous and isolipidic diets were formulated: Diet 1 (control): No DON added; Diets 2–5 or Diets 6–9: 0.5 or 3.0 mg added DON/kg diet + 0%, 0.1%, 0.2%, or 0.4% YCWE, respectively. Results showed that Diet 6 (3 mg/kg DON, 0% YCWE) significantly decreased weight gain, specific growth rate and feed efficiency ratio of fish and reduced immunoglobulin M and complement 4 concentrations in serum. Fish fed Diet 6 presented morphological alterations, lower activity of superoxide dismutase, catalase and total antioxidant capacity but higher malondialdehyde content, lower claudin-4 and occludin expression but higher interleukin-1β expression in intestine. Besides, Diet 6 decreased the abundance of potential helpful bacteria but increased the abundance of potential pathogens in intestine. While, dietary YCWE, especially Diet 8 (3 mg/kg DON, 0.2% YCWE) and 9 (3 mg/kg DON, 0.4% YCWE), markedly improved growth performance and immune response and enhanced the intestinal health of turbot. In conclusion, dietary YCWE could mitigate the toxic effects induced by DON in turbot, and could be used as an effective strategy to control DON contamination in fish feed. |
format |
Article in Journal/Newspaper |
author |
Tiantian Wang Jinzhu Yang Gang Lin Mingzhu Li Ronghua Zhu Alexandros Yiannikouris Ruiguo Wang Yanjiao Zhang Kangsen Mai |
author_facet |
Tiantian Wang Jinzhu Yang Gang Lin Mingzhu Li Ronghua Zhu Alexandros Yiannikouris Ruiguo Wang Yanjiao Zhang Kangsen Mai |
author_sort |
Tiantian Wang |
title |
Evaluation of the mitigation efficacy of a yeast cell wall extract toward deoxynivalenol contaminated diet fed to turbot (Scophthalmus maximus) |
title_short |
Evaluation of the mitigation efficacy of a yeast cell wall extract toward deoxynivalenol contaminated diet fed to turbot (Scophthalmus maximus) |
title_full |
Evaluation of the mitigation efficacy of a yeast cell wall extract toward deoxynivalenol contaminated diet fed to turbot (Scophthalmus maximus) |
title_fullStr |
Evaluation of the mitigation efficacy of a yeast cell wall extract toward deoxynivalenol contaminated diet fed to turbot (Scophthalmus maximus) |
title_full_unstemmed |
Evaluation of the mitigation efficacy of a yeast cell wall extract toward deoxynivalenol contaminated diet fed to turbot (Scophthalmus maximus) |
title_sort |
evaluation of the mitigation efficacy of a yeast cell wall extract toward deoxynivalenol contaminated diet fed to turbot (scophthalmus maximus) |
publisher |
Elsevier |
publishDate |
2021 |
url |
https://doi.org/10.1016/j.ecoenv.2021.112221 https://doaj.org/article/a2e8d352c2be441caf2cdd463886842d |
genre |
Scophthalmus maximus Turbot |
genre_facet |
Scophthalmus maximus Turbot |
op_source |
Ecotoxicology and Environmental Safety, Vol 216, Iss , Pp 112221- (2021) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S0147651321003328 https://doaj.org/toc/0147-6513 0147-6513 doi:10.1016/j.ecoenv.2021.112221 https://doaj.org/article/a2e8d352c2be441caf2cdd463886842d |
op_doi |
https://doi.org/10.1016/j.ecoenv.2021.112221 |
container_title |
Ecotoxicology and Environmental Safety |
container_volume |
216 |
container_start_page |
112221 |
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1766189105912217600 |