Burden and impact of Plasmodium vivax in pregnancy: A multi-centre prospective observational study.
Despite that over 90 million pregnancies are at risk of Plasmodium vivax infection annually, little is known about the epidemiology and impact of the infection in pregnancy.We undertook a health facility-based prospective observational study in pregnant women from Guatemala (GT), Colombia (CO), Braz...
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ftdoajarticles:oai:doaj.org/article:a2e52984632e429abd1694573b68e119 2023-05-15T15:18:37+02:00 Burden and impact of Plasmodium vivax in pregnancy: A multi-centre prospective observational study. Azucena Bardají Flor Ernestina Martínez-Espinosa Myriam Arévalo-Herrera Norma Padilla Swati Kochar Maria Ome-Kaius Camila Bôtto-Menezes María Eugenia Castellanos Dhanpat Kumar Kochar Sanjay Kumar Kochar Inoni Betuela Ivo Mueller Stephen Rogerson Chetan Chitnis Dhiraj Hans Michela Menegon Carlo Severini Hernando Del Portillo Carlota Dobaño Alfredo Mayor Jaume Ordi Mireia Piqueras Sergi Sanz Mats Wahlgren Laurence Slutsker Meghna Desai Clara Menéndez PregVax Study Group 2017-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005606 https://doaj.org/article/a2e52984632e429abd1694573b68e119 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5481034?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005606 https://doaj.org/article/a2e52984632e429abd1694573b68e119 PLoS Neglected Tropical Diseases, Vol 11, Iss 6, p e0005606 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005606 2022-12-31T10:36:08Z Despite that over 90 million pregnancies are at risk of Plasmodium vivax infection annually, little is known about the epidemiology and impact of the infection in pregnancy.We undertook a health facility-based prospective observational study in pregnant women from Guatemala (GT), Colombia (CO), Brazil (BR), India (IN) and Papua New Guinea PNG). Malaria and anemia were determined during pregnancy and fetal outcomes assessed at delivery. A total of 9388 women were enrolled at antennal care (ANC), of whom 53% (4957) were followed until delivery. Prevalence of P. vivax monoinfection in maternal blood at delivery was 0.4% (20/4461) by microscopy [GT 0.1%, CO 0.5%, BR 0.1%, IN 0.2%, PNG 1.2%] and 7% (104/1488) by PCR. P. falciparum monoinfection was found in 0.5% (22/4463) of women by microscopy [GT 0%, CO 0.5%, BR 0%, IN 0%, PNG 2%]. P. vivax infection was observed in 0.4% (14/3725) of placentas examined by microscopy and in 3.7% (19/508) by PCR. P. vivax in newborn blood was detected in 0.02% (1/4302) of samples examined by microscopy [in cord blood; 0.05% (2/4040) by microscopy, and 2.6% (13/497) by PCR]. Clinical P. vivax infection was associated with increased risk of maternal anemia (Odds Ratio-OR, 5.48, [95% CI 1.83-16.41]; p = 0.009), while submicroscopic vivax infection was not associated with increased risk of moderate-severe anemia (Hb<8g/dL) (OR, 1.16, [95% CI 0.52-2.59]; p = 0.717), or low birth weight (<2500g) (OR, 0.52, [95% CI, 0.23-1.16]; p = 0.110).In this multicenter study, the prevalence of P. vivax infection in pregnancy by microscopy was overall low across all endemic study sites; however, molecular methods revealed a significant number of submicroscopic infections. Clinical vivax infection in pregnancy was associated with maternal anemia, which may be deleterious for infant's health. These results may help to guide maternal health programs in settings where vivax malaria is endemic; they also highlight the need of addressing a vulnerable population such as pregnant women while embracing ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 6 e0005606 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Azucena Bardají Flor Ernestina Martínez-Espinosa Myriam Arévalo-Herrera Norma Padilla Swati Kochar Maria Ome-Kaius Camila Bôtto-Menezes María Eugenia Castellanos Dhanpat Kumar Kochar Sanjay Kumar Kochar Inoni Betuela Ivo Mueller Stephen Rogerson Chetan Chitnis Dhiraj Hans Michela Menegon Carlo Severini Hernando Del Portillo Carlota Dobaño Alfredo Mayor Jaume Ordi Mireia Piqueras Sergi Sanz Mats Wahlgren Laurence Slutsker Meghna Desai Clara Menéndez PregVax Study Group Burden and impact of Plasmodium vivax in pregnancy: A multi-centre prospective observational study. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Despite that over 90 million pregnancies are at risk of Plasmodium vivax infection annually, little is known about the epidemiology and impact of the infection in pregnancy.We undertook a health facility-based prospective observational study in pregnant women from Guatemala (GT), Colombia (CO), Brazil (BR), India (IN) and Papua New Guinea PNG). Malaria and anemia were determined during pregnancy and fetal outcomes assessed at delivery. A total of 9388 women were enrolled at antennal care (ANC), of whom 53% (4957) were followed until delivery. Prevalence of P. vivax monoinfection in maternal blood at delivery was 0.4% (20/4461) by microscopy [GT 0.1%, CO 0.5%, BR 0.1%, IN 0.2%, PNG 1.2%] and 7% (104/1488) by PCR. P. falciparum monoinfection was found in 0.5% (22/4463) of women by microscopy [GT 0%, CO 0.5%, BR 0%, IN 0%, PNG 2%]. P. vivax infection was observed in 0.4% (14/3725) of placentas examined by microscopy and in 3.7% (19/508) by PCR. P. vivax in newborn blood was detected in 0.02% (1/4302) of samples examined by microscopy [in cord blood; 0.05% (2/4040) by microscopy, and 2.6% (13/497) by PCR]. Clinical P. vivax infection was associated with increased risk of maternal anemia (Odds Ratio-OR, 5.48, [95% CI 1.83-16.41]; p = 0.009), while submicroscopic vivax infection was not associated with increased risk of moderate-severe anemia (Hb<8g/dL) (OR, 1.16, [95% CI 0.52-2.59]; p = 0.717), or low birth weight (<2500g) (OR, 0.52, [95% CI, 0.23-1.16]; p = 0.110).In this multicenter study, the prevalence of P. vivax infection in pregnancy by microscopy was overall low across all endemic study sites; however, molecular methods revealed a significant number of submicroscopic infections. Clinical vivax infection in pregnancy was associated with maternal anemia, which may be deleterious for infant's health. These results may help to guide maternal health programs in settings where vivax malaria is endemic; they also highlight the need of addressing a vulnerable population such as pregnant women while embracing ... |
format |
Article in Journal/Newspaper |
author |
Azucena Bardají Flor Ernestina Martínez-Espinosa Myriam Arévalo-Herrera Norma Padilla Swati Kochar Maria Ome-Kaius Camila Bôtto-Menezes María Eugenia Castellanos Dhanpat Kumar Kochar Sanjay Kumar Kochar Inoni Betuela Ivo Mueller Stephen Rogerson Chetan Chitnis Dhiraj Hans Michela Menegon Carlo Severini Hernando Del Portillo Carlota Dobaño Alfredo Mayor Jaume Ordi Mireia Piqueras Sergi Sanz Mats Wahlgren Laurence Slutsker Meghna Desai Clara Menéndez PregVax Study Group |
author_facet |
Azucena Bardají Flor Ernestina Martínez-Espinosa Myriam Arévalo-Herrera Norma Padilla Swati Kochar Maria Ome-Kaius Camila Bôtto-Menezes María Eugenia Castellanos Dhanpat Kumar Kochar Sanjay Kumar Kochar Inoni Betuela Ivo Mueller Stephen Rogerson Chetan Chitnis Dhiraj Hans Michela Menegon Carlo Severini Hernando Del Portillo Carlota Dobaño Alfredo Mayor Jaume Ordi Mireia Piqueras Sergi Sanz Mats Wahlgren Laurence Slutsker Meghna Desai Clara Menéndez PregVax Study Group |
author_sort |
Azucena Bardají |
title |
Burden and impact of Plasmodium vivax in pregnancy: A multi-centre prospective observational study. |
title_short |
Burden and impact of Plasmodium vivax in pregnancy: A multi-centre prospective observational study. |
title_full |
Burden and impact of Plasmodium vivax in pregnancy: A multi-centre prospective observational study. |
title_fullStr |
Burden and impact of Plasmodium vivax in pregnancy: A multi-centre prospective observational study. |
title_full_unstemmed |
Burden and impact of Plasmodium vivax in pregnancy: A multi-centre prospective observational study. |
title_sort |
burden and impact of plasmodium vivax in pregnancy: a multi-centre prospective observational study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005606 https://doaj.org/article/a2e52984632e429abd1694573b68e119 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 6, p e0005606 (2017) |
op_relation |
http://europepmc.org/articles/PMC5481034?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005606 https://doaj.org/article/a2e52984632e429abd1694573b68e119 |
op_doi |
https://doi.org/10.1371/journal.pntd.0005606 |
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PLOS Neglected Tropical Diseases |
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6 |
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e0005606 |
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