Comparison of the QuantiFERON®-TB Gold assay and tuberculin skin test to detect latent tuberculosis infection among target groups in Trinidad & Tobago Comparación entre la prueba QuantiFERON®-TB Gold y la prueba cutánea de la tuberculina para detectar la infección tuberculosa latente en grupos destinatarios en Trinidad y Tabago
OBJECTIVE: To compare the QuantiFERON®-TB Gold (QFT-G) assay and tuberculin skin test (TST) in screening/diagnosis of latent tuberculosis infection (LTBI) among individuals in Trinidad & Tobago at high risk for TB. METHODS: A total of 560 individuals (TB patient contacts, HIV patients, health ca...
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Pan American Health Organization
2010
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ftdoajarticles:oai:doaj.org/article:a2c4d761eb734869a2d98ba93687965a 2023-05-15T15:19:26+02:00 Comparison of the QuantiFERON®-TB Gold assay and tuberculin skin test to detect latent tuberculosis infection among target groups in Trinidad & Tobago Comparación entre la prueba QuantiFERON®-TB Gold y la prueba cutánea de la tuberculina para detectar la infección tuberculosa latente en grupos destinatarios en Trinidad y Tabago Shirematee Baboolal Dottin Ramoutar Patrick Eberechi Akpaka 2010-07-01T00:00:00Z https://doaj.org/article/a2c4d761eb734869a2d98ba93687965a EN ES PT eng spa por Pan American Health Organization http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892010000700006 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 https://doaj.org/article/a2c4d761eb734869a2d98ba93687965a Revista Panamericana de Salud Pública, Vol 28, Iss 1, Pp 36-42 (2010) Tuberculosis latente prueba de tuberculina prueba ELISA Trinidad y Tabago Latent tuberculosis tuberculin test enzyme-linked immunosorbent assay Trinidad and Tobago Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2010 ftdoajarticles 2022-12-30T21:58:10Z OBJECTIVE: To compare the QuantiFERON®-TB Gold (QFT-G) assay and tuberculin skin test (TST) in screening/diagnosis of latent tuberculosis infection (LTBI) among individuals in Trinidad & Tobago at high risk for TB. METHODS: A total of 560 individuals (TB patient contacts, HIV patients, health care workers, prison inmates, and TB patients [controls]) were recruited for the study. Blood was drawn and processed using the QFT-G assay, followed by immediate administration of TST solution on subjects' forearm. Data were analyzed with Epi InfoTM 3.5.1 software. Results were compared across the target groups using the chi-square test (P < 0.05). RESULTS: The QFT-G assay detected LTBI in 51% of the subjects (with most positive results occurring among the control group) whereas the TST detected it in 39.4% (P = 0.001). Overall, the QFT-G assay detected LTBI more frequently than the TST among all subjects except the control group, where detection favored the TST. The QFT-G assay produced indeterminate and nonreactive results in some HIV patients but required less turnaround time than the TST (23.3 h versus 70.2 h; P < 0.0001). The TST cost less per subject than the QFT-G assay (US $3.70 versus US $18.60; P = 0.0008). CONCLUSIONS: The QFT-G assay cost more but had a higher detection rate among most target groups and required less turnaround time than the TST. However, its sensitivity was lower among immunocompromised subjects. Therefore, the QFT-G assay should be used with caution for LBTI screening/diagnosis in resource-poor, high-HIV prevalence settings such as Trinidad & Tobago. OBJETIVO: Comparar la prueba QuantiFERON®-TB Gold (QFT-G) con la prueba cutánea de la tuberculina (PPD) para el tamizaje y diagnóstico de la infección tuberculosa latente (ITBL) en personas con alto riesgo de tuberculosis en Trinidad y Tabago. MÉTODOS: Para el estudio, se reclutó un total de 560 individuos (personas en contacto con pacientes de tuberculosis, pacientes con VIH, trabajadores de la salud, presidiarios y pacientes de ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Trinidad ENVELOPE(-60.734,-60.734,-63.816,-63.816) |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Spanish Portuguese |
topic |
Tuberculosis latente prueba de tuberculina prueba ELISA Trinidad y Tabago Latent tuberculosis tuberculin test enzyme-linked immunosorbent assay Trinidad and Tobago Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Tuberculosis latente prueba de tuberculina prueba ELISA Trinidad y Tabago Latent tuberculosis tuberculin test enzyme-linked immunosorbent assay Trinidad and Tobago Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Shirematee Baboolal Dottin Ramoutar Patrick Eberechi Akpaka Comparison of the QuantiFERON®-TB Gold assay and tuberculin skin test to detect latent tuberculosis infection among target groups in Trinidad & Tobago Comparación entre la prueba QuantiFERON®-TB Gold y la prueba cutánea de la tuberculina para detectar la infección tuberculosa latente en grupos destinatarios en Trinidad y Tabago |
topic_facet |
Tuberculosis latente prueba de tuberculina prueba ELISA Trinidad y Tabago Latent tuberculosis tuberculin test enzyme-linked immunosorbent assay Trinidad and Tobago Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
OBJECTIVE: To compare the QuantiFERON®-TB Gold (QFT-G) assay and tuberculin skin test (TST) in screening/diagnosis of latent tuberculosis infection (LTBI) among individuals in Trinidad & Tobago at high risk for TB. METHODS: A total of 560 individuals (TB patient contacts, HIV patients, health care workers, prison inmates, and TB patients [controls]) were recruited for the study. Blood was drawn and processed using the QFT-G assay, followed by immediate administration of TST solution on subjects' forearm. Data were analyzed with Epi InfoTM 3.5.1 software. Results were compared across the target groups using the chi-square test (P < 0.05). RESULTS: The QFT-G assay detected LTBI in 51% of the subjects (with most positive results occurring among the control group) whereas the TST detected it in 39.4% (P = 0.001). Overall, the QFT-G assay detected LTBI more frequently than the TST among all subjects except the control group, where detection favored the TST. The QFT-G assay produced indeterminate and nonreactive results in some HIV patients but required less turnaround time than the TST (23.3 h versus 70.2 h; P < 0.0001). The TST cost less per subject than the QFT-G assay (US $3.70 versus US $18.60; P = 0.0008). CONCLUSIONS: The QFT-G assay cost more but had a higher detection rate among most target groups and required less turnaround time than the TST. However, its sensitivity was lower among immunocompromised subjects. Therefore, the QFT-G assay should be used with caution for LBTI screening/diagnosis in resource-poor, high-HIV prevalence settings such as Trinidad & Tobago. OBJETIVO: Comparar la prueba QuantiFERON®-TB Gold (QFT-G) con la prueba cutánea de la tuberculina (PPD) para el tamizaje y diagnóstico de la infección tuberculosa latente (ITBL) en personas con alto riesgo de tuberculosis en Trinidad y Tabago. MÉTODOS: Para el estudio, se reclutó un total de 560 individuos (personas en contacto con pacientes de tuberculosis, pacientes con VIH, trabajadores de la salud, presidiarios y pacientes de ... |
format |
Article in Journal/Newspaper |
author |
Shirematee Baboolal Dottin Ramoutar Patrick Eberechi Akpaka |
author_facet |
Shirematee Baboolal Dottin Ramoutar Patrick Eberechi Akpaka |
author_sort |
Shirematee Baboolal |
title |
Comparison of the QuantiFERON®-TB Gold assay and tuberculin skin test to detect latent tuberculosis infection among target groups in Trinidad & Tobago Comparación entre la prueba QuantiFERON®-TB Gold y la prueba cutánea de la tuberculina para detectar la infección tuberculosa latente en grupos destinatarios en Trinidad y Tabago |
title_short |
Comparison of the QuantiFERON®-TB Gold assay and tuberculin skin test to detect latent tuberculosis infection among target groups in Trinidad & Tobago Comparación entre la prueba QuantiFERON®-TB Gold y la prueba cutánea de la tuberculina para detectar la infección tuberculosa latente en grupos destinatarios en Trinidad y Tabago |
title_full |
Comparison of the QuantiFERON®-TB Gold assay and tuberculin skin test to detect latent tuberculosis infection among target groups in Trinidad & Tobago Comparación entre la prueba QuantiFERON®-TB Gold y la prueba cutánea de la tuberculina para detectar la infección tuberculosa latente en grupos destinatarios en Trinidad y Tabago |
title_fullStr |
Comparison of the QuantiFERON®-TB Gold assay and tuberculin skin test to detect latent tuberculosis infection among target groups in Trinidad & Tobago Comparación entre la prueba QuantiFERON®-TB Gold y la prueba cutánea de la tuberculina para detectar la infección tuberculosa latente en grupos destinatarios en Trinidad y Tabago |
title_full_unstemmed |
Comparison of the QuantiFERON®-TB Gold assay and tuberculin skin test to detect latent tuberculosis infection among target groups in Trinidad & Tobago Comparación entre la prueba QuantiFERON®-TB Gold y la prueba cutánea de la tuberculina para detectar la infección tuberculosa latente en grupos destinatarios en Trinidad y Tabago |
title_sort |
comparison of the quantiferon®-tb gold assay and tuberculin skin test to detect latent tuberculosis infection among target groups in trinidad & tobago comparación entre la prueba quantiferon®-tb gold y la prueba cutánea de la tuberculina para detectar la infección tuberculosa latente en grupos destinatarios en trinidad y tabago |
publisher |
Pan American Health Organization |
publishDate |
2010 |
url |
https://doaj.org/article/a2c4d761eb734869a2d98ba93687965a |
long_lat |
ENVELOPE(-60.734,-60.734,-63.816,-63.816) |
geographic |
Arctic Trinidad |
geographic_facet |
Arctic Trinidad |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 28, Iss 1, Pp 36-42 (2010) |
op_relation |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892010000700006 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 https://doaj.org/article/a2c4d761eb734869a2d98ba93687965a |
_version_ |
1766349626655375360 |