Vaccine-associated paralytic poliomyelitis in Brazil, 1989-1995
At the present time, the only poliovirus-caused poliomyelitis cases reported in Brazil and other countries of the Americas are of vaccine etiology. It is important for epidemiological surveillance and immunization programs to evaluate the epidemiological profile of cases of vaccine-associated paraly...
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Pan American Health Organization
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ftdoajarticles:oai:doaj.org/article:a28fd064f28b450f8eb15acf31829867 2023-05-15T15:12:27+02:00 Vaccine-associated paralytic poliomyelitis in Brazil, 1989-1995 Lúcia Helena de Oliveira Claudio José Struchiner 2000-04-01T00:00:00Z https://doi.org/10.1590/s1020-49892000000400002 https://doaj.org/article/a28fd064f28b450f8eb15acf31829867 EN ES PT eng spa por Pan American Health Organization http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892000000400002&lng=en&tlng=en https://doaj.org/toc/1020-4989 1020-4989 doi:10.1590/s1020-49892000000400002 https://doaj.org/article/a28fd064f28b450f8eb15acf31829867 Revista Panamericana de Salud Pública, Vol 7, Iss 4, Pp 219-224 (2000) Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2000 ftdoajarticles https://doi.org/10.1590/s1020-49892000000400002 2022-12-31T11:40:19Z At the present time, the only poliovirus-caused poliomyelitis cases reported in Brazil and other countries of the Americas are of vaccine etiology. It is important for epidemiological surveillance and immunization programs to evaluate the epidemiological profile of cases of vaccine-associated paralytic poliomyelitis (VAPP) in order to establish criteria for case definition and vaccination strategies. To research VAPP in Brazil, 30 cases diagnosed and classified as such by the Ministry of Health between 1989 and 1995 were submitted to a descriptive study of clinical, laboratory, and epidemiological data. In addition, the risk of occurrence of VAPP was estimated in relation to determinants based on a cohort of 3 656 persons with acute flaccid paralysis. Among individuals who had received oral polio vaccine (OPV) from 4 to 40 days before the onset of paralysis, we found a relative risk of 8.88 (95% CI: 4.37-18.03) for VAPP as compared with persons who had not been vaccinated during the same time interval. For individuals who developed VAPP in the period following national vaccination days, the estimated relative risk was 2.94 (95% CI: 1.44-6.00). For the first dose of OPV administered to the general population the estimated risk was 1 case of VAPP for every 2.39 million doses; for total doses of OPV the risk was 1 case in 13.03 million doses. A major share of VAPP cases were related to children affected by prodromes (fever and gastrointestinal signs and/or symptoms), isolation of vaccine poliovirus type 2, paralysis of the lower limbs, and a mean age of 1 year. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista Panamericana de Salud Pública 7 4 219 224 |
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Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Lúcia Helena de Oliveira Claudio José Struchiner Vaccine-associated paralytic poliomyelitis in Brazil, 1989-1995 |
topic_facet |
Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
At the present time, the only poliovirus-caused poliomyelitis cases reported in Brazil and other countries of the Americas are of vaccine etiology. It is important for epidemiological surveillance and immunization programs to evaluate the epidemiological profile of cases of vaccine-associated paralytic poliomyelitis (VAPP) in order to establish criteria for case definition and vaccination strategies. To research VAPP in Brazil, 30 cases diagnosed and classified as such by the Ministry of Health between 1989 and 1995 were submitted to a descriptive study of clinical, laboratory, and epidemiological data. In addition, the risk of occurrence of VAPP was estimated in relation to determinants based on a cohort of 3 656 persons with acute flaccid paralysis. Among individuals who had received oral polio vaccine (OPV) from 4 to 40 days before the onset of paralysis, we found a relative risk of 8.88 (95% CI: 4.37-18.03) for VAPP as compared with persons who had not been vaccinated during the same time interval. For individuals who developed VAPP in the period following national vaccination days, the estimated relative risk was 2.94 (95% CI: 1.44-6.00). For the first dose of OPV administered to the general population the estimated risk was 1 case of VAPP for every 2.39 million doses; for total doses of OPV the risk was 1 case in 13.03 million doses. A major share of VAPP cases were related to children affected by prodromes (fever and gastrointestinal signs and/or symptoms), isolation of vaccine poliovirus type 2, paralysis of the lower limbs, and a mean age of 1 year. |
format |
Article in Journal/Newspaper |
author |
Lúcia Helena de Oliveira Claudio José Struchiner |
author_facet |
Lúcia Helena de Oliveira Claudio José Struchiner |
author_sort |
Lúcia Helena de Oliveira |
title |
Vaccine-associated paralytic poliomyelitis in Brazil, 1989-1995 |
title_short |
Vaccine-associated paralytic poliomyelitis in Brazil, 1989-1995 |
title_full |
Vaccine-associated paralytic poliomyelitis in Brazil, 1989-1995 |
title_fullStr |
Vaccine-associated paralytic poliomyelitis in Brazil, 1989-1995 |
title_full_unstemmed |
Vaccine-associated paralytic poliomyelitis in Brazil, 1989-1995 |
title_sort |
vaccine-associated paralytic poliomyelitis in brazil, 1989-1995 |
publisher |
Pan American Health Organization |
publishDate |
2000 |
url |
https://doi.org/10.1590/s1020-49892000000400002 https://doaj.org/article/a28fd064f28b450f8eb15acf31829867 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 7, Iss 4, Pp 219-224 (2000) |
op_relation |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892000000400002&lng=en&tlng=en https://doaj.org/toc/1020-4989 1020-4989 doi:10.1590/s1020-49892000000400002 https://doaj.org/article/a28fd064f28b450f8eb15acf31829867 |
op_doi |
https://doi.org/10.1590/s1020-49892000000400002 |
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Revista Panamericana de Salud Pública |
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7 |
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