Adherence to Artemisinin-Based Combination Therapy for the Treatment of Uncomplicated Malaria: A Systematic Review and Meta-Analysis
Adherence to artemisinin-based combination therapy (ACT) is not clearly defined. This meta-analysis determines the prevalence and predictors of adherence to ACT. Twenty-five studies and six substudies met the inclusion criteria. The prevalence of ACT adherence in the public sector was significantly...
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ftdoajarticles:oai:doaj.org/article:a28370d8fc604472a64eb73efec848bb 2024-09-09T19:25:53+00:00 Adherence to Artemisinin-Based Combination Therapy for the Treatment of Uncomplicated Malaria: A Systematic Review and Meta-Analysis Ahmad M. Yakasai Muhammad Hamza Mahmood M. Dalhat Musa Bello Muktar A. Gadanya Zuwaira M. Yaqub Daiyabu A. Ibrahim Fatimah Hassan-Hanga 2015-01-01T00:00:00Z https://doi.org/10.1155/2015/189232 https://doaj.org/article/a28370d8fc604472a64eb73efec848bb EN eng Wiley http://dx.doi.org/10.1155/2015/189232 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2015/189232 https://doaj.org/article/a28370d8fc604472a64eb73efec848bb Journal of Tropical Medicine, Vol 2015 (2015) Arctic medicine. Tropical medicine RC955-962 article 2015 ftdoajarticles https://doi.org/10.1155/2015/189232 2024-08-05T17:48:39Z Adherence to artemisinin-based combination therapy (ACT) is not clearly defined. This meta-analysis determines the prevalence and predictors of adherence to ACT. Twenty-five studies and six substudies met the inclusion criteria. The prevalence of ACT adherence in the public sector was significantly higher compared to retail sector (76% and 45%, resp., P<0.0001). However, ACT adherence was similar across different ACT dosing regimens and formulations. In metaregression analysis prevalence estimates of adherence significantly decrease with increasing year of study publication P=0.046. Factors found to be significant predictors of ACT adherence were years of education ≥ 7 {odds ratio (OR) (95% CI) = 1.63 (1.05–2.53)}, higher income {2.0 (1.35–2.98)}, fatty food {4.6 (2.49–8.50)}, exact number of pills dispensed {4.09 (1.60–10.7)}, and belief in traditional medication for malaria {0.09 (0.01–0.78)}. The accuracy of pooled estimates could be limited by publication bias, and differing methods and thresholds of assessing adherence. To improve ACT adherence, educational programs to increase awareness and understanding of ACT dosing regimen are interventions urgently needed. Patients and caregivers should be provided with an adequate explanation at the time of prescribing and/or dispensing ACT. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2015 1 11 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Ahmad M. Yakasai Muhammad Hamza Mahmood M. Dalhat Musa Bello Muktar A. Gadanya Zuwaira M. Yaqub Daiyabu A. Ibrahim Fatimah Hassan-Hanga Adherence to Artemisinin-Based Combination Therapy for the Treatment of Uncomplicated Malaria: A Systematic Review and Meta-Analysis |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Adherence to artemisinin-based combination therapy (ACT) is not clearly defined. This meta-analysis determines the prevalence and predictors of adherence to ACT. Twenty-five studies and six substudies met the inclusion criteria. The prevalence of ACT adherence in the public sector was significantly higher compared to retail sector (76% and 45%, resp., P<0.0001). However, ACT adherence was similar across different ACT dosing regimens and formulations. In metaregression analysis prevalence estimates of adherence significantly decrease with increasing year of study publication P=0.046. Factors found to be significant predictors of ACT adherence were years of education ≥ 7 {odds ratio (OR) (95% CI) = 1.63 (1.05–2.53)}, higher income {2.0 (1.35–2.98)}, fatty food {4.6 (2.49–8.50)}, exact number of pills dispensed {4.09 (1.60–10.7)}, and belief in traditional medication for malaria {0.09 (0.01–0.78)}. The accuracy of pooled estimates could be limited by publication bias, and differing methods and thresholds of assessing adherence. To improve ACT adherence, educational programs to increase awareness and understanding of ACT dosing regimen are interventions urgently needed. Patients and caregivers should be provided with an adequate explanation at the time of prescribing and/or dispensing ACT. |
format |
Article in Journal/Newspaper |
author |
Ahmad M. Yakasai Muhammad Hamza Mahmood M. Dalhat Musa Bello Muktar A. Gadanya Zuwaira M. Yaqub Daiyabu A. Ibrahim Fatimah Hassan-Hanga |
author_facet |
Ahmad M. Yakasai Muhammad Hamza Mahmood M. Dalhat Musa Bello Muktar A. Gadanya Zuwaira M. Yaqub Daiyabu A. Ibrahim Fatimah Hassan-Hanga |
author_sort |
Ahmad M. Yakasai |
title |
Adherence to Artemisinin-Based Combination Therapy for the Treatment of Uncomplicated Malaria: A Systematic Review and Meta-Analysis |
title_short |
Adherence to Artemisinin-Based Combination Therapy for the Treatment of Uncomplicated Malaria: A Systematic Review and Meta-Analysis |
title_full |
Adherence to Artemisinin-Based Combination Therapy for the Treatment of Uncomplicated Malaria: A Systematic Review and Meta-Analysis |
title_fullStr |
Adherence to Artemisinin-Based Combination Therapy for the Treatment of Uncomplicated Malaria: A Systematic Review and Meta-Analysis |
title_full_unstemmed |
Adherence to Artemisinin-Based Combination Therapy for the Treatment of Uncomplicated Malaria: A Systematic Review and Meta-Analysis |
title_sort |
adherence to artemisinin-based combination therapy for the treatment of uncomplicated malaria: a systematic review and meta-analysis |
publisher |
Wiley |
publishDate |
2015 |
url |
https://doi.org/10.1155/2015/189232 https://doaj.org/article/a28370d8fc604472a64eb73efec848bb |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2015 (2015) |
op_relation |
http://dx.doi.org/10.1155/2015/189232 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2015/189232 https://doaj.org/article/a28370d8fc604472a64eb73efec848bb |
op_doi |
https://doi.org/10.1155/2015/189232 |
container_title |
Journal of Tropical Medicine |
container_volume |
2015 |
container_start_page |
1 |
op_container_end_page |
11 |
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1809895592553349120 |