Fulminant hepatitis: a clinical review of 11 years
24 cases of fulminant hepatitis (FH) hospitalized in the Clínica de Doenças Infecciosas e Parasitárias do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo during the period from January 1976 to December 1986 were reviewed from their clinical, epidemiological and laboratori...
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Universidade de São Paulo (USP)
1989
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ftdoajarticles:oai:doaj.org/article:a27ec0efaa2449339564235da78aa128 2024-09-09T19:28:09+00:00 Fulminant hepatitis: a clinical review of 11 years Anna Sara Shafferman Levin Antonio Alci Barone Mario Shiroma 1989-08-01T00:00:00Z https://doi.org/10.1590/S0036-46651989000400002 https://doaj.org/article/a27ec0efaa2449339564235da78aa128 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651989000400002&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46651989000400002 https://doaj.org/article/a27ec0efaa2449339564235da78aa128 Revista do Instituto de Medicina Tropical de São Paulo, Vol 31, Iss 4, Pp 213-220 (1989) Fulminant hepatitis Occurrence Complications Yellow fever Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1989 ftdoajarticles https://doi.org/10.1590/S0036-46651989000400002 2024-08-05T17:49:30Z 24 cases of fulminant hepatitis (FH) hospitalized in the Clínica de Doenças Infecciosas e Parasitárias do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo during the period from January 1976 to December 1986 were reviewed from their clinical, epidemiological and laboratorial aspects. 88% of the patients died; 20 patients (83%) presented hemorrhages and, of these, 19 died. Bacterial infections occurred in 14 patients (58%) all of whom died. Ascitis was noted in 3 cases; cerebral edema was present in 16 cases. Maximal ALT levels for each patient during hospitalization ranged widely from 81 to 4,460 UI/l. Thirteen patients presented high creatinine levels (54%). Prothrombin time activity ranged from 2.1% to 67%. Fever was present in 20 cases (83%). Encephalopathy occurred within the first 2 weeks of illness in 72% of the cases. In 7 cases other illnesses were present. The etiology could not be determined in 13 cases. In 3 cases it was due to yellow fever and 6 cases were caused by viruses other than yellow fever. In one case the cause was drug usage and in another case, possibly alcohol. The authors believe that the clinical definition of FH requires further discussion before it is established. In this study FH is a young person's disease. The mortality found was similar to that by other authors. Factors that contributed to death were: hemorrhages and bacterial infection. Factors that worsened the prognosis of hepatitis were: associated illnesses and surgical procedure. The levels of ALT during hospitalization did not correlate well with the severity of the hepatitis. The authors believe that yellow fever should be considered a cause of FH where the clinical picture meets the criteria for such, although its mechanisms of encephalopathy remain obscure. The clinical details of the 3 cases of yellow fever are presented. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 31 4 213 220 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Fulminant hepatitis Occurrence Complications Yellow fever Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Fulminant hepatitis Occurrence Complications Yellow fever Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Anna Sara Shafferman Levin Antonio Alci Barone Mario Shiroma Fulminant hepatitis: a clinical review of 11 years |
topic_facet |
Fulminant hepatitis Occurrence Complications Yellow fever Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
24 cases of fulminant hepatitis (FH) hospitalized in the Clínica de Doenças Infecciosas e Parasitárias do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo during the period from January 1976 to December 1986 were reviewed from their clinical, epidemiological and laboratorial aspects. 88% of the patients died; 20 patients (83%) presented hemorrhages and, of these, 19 died. Bacterial infections occurred in 14 patients (58%) all of whom died. Ascitis was noted in 3 cases; cerebral edema was present in 16 cases. Maximal ALT levels for each patient during hospitalization ranged widely from 81 to 4,460 UI/l. Thirteen patients presented high creatinine levels (54%). Prothrombin time activity ranged from 2.1% to 67%. Fever was present in 20 cases (83%). Encephalopathy occurred within the first 2 weeks of illness in 72% of the cases. In 7 cases other illnesses were present. The etiology could not be determined in 13 cases. In 3 cases it was due to yellow fever and 6 cases were caused by viruses other than yellow fever. In one case the cause was drug usage and in another case, possibly alcohol. The authors believe that the clinical definition of FH requires further discussion before it is established. In this study FH is a young person's disease. The mortality found was similar to that by other authors. Factors that contributed to death were: hemorrhages and bacterial infection. Factors that worsened the prognosis of hepatitis were: associated illnesses and surgical procedure. The levels of ALT during hospitalization did not correlate well with the severity of the hepatitis. The authors believe that yellow fever should be considered a cause of FH where the clinical picture meets the criteria for such, although its mechanisms of encephalopathy remain obscure. The clinical details of the 3 cases of yellow fever are presented. |
format |
Article in Journal/Newspaper |
author |
Anna Sara Shafferman Levin Antonio Alci Barone Mario Shiroma |
author_facet |
Anna Sara Shafferman Levin Antonio Alci Barone Mario Shiroma |
author_sort |
Anna Sara Shafferman Levin |
title |
Fulminant hepatitis: a clinical review of 11 years |
title_short |
Fulminant hepatitis: a clinical review of 11 years |
title_full |
Fulminant hepatitis: a clinical review of 11 years |
title_fullStr |
Fulminant hepatitis: a clinical review of 11 years |
title_full_unstemmed |
Fulminant hepatitis: a clinical review of 11 years |
title_sort |
fulminant hepatitis: a clinical review of 11 years |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1989 |
url |
https://doi.org/10.1590/S0036-46651989000400002 https://doaj.org/article/a27ec0efaa2449339564235da78aa128 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 31, Iss 4, Pp 213-220 (1989) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651989000400002&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46651989000400002 https://doaj.org/article/a27ec0efaa2449339564235da78aa128 |
op_doi |
https://doi.org/10.1590/S0036-46651989000400002 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
container_volume |
31 |
container_issue |
4 |
container_start_page |
213 |
op_container_end_page |
220 |
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