Host genotype by parasite genotype interactions underlying the resistance of anopheline mosquitoes to Plasmodium falciparum
Abstract Background Most studies on the resistance of mosquitoes to their malaria parasites focus on the response of a mosquito line or colony against a single parasite genotype. In natural situations, however, it may be expected that mosquito-malaria relationships are based, as are many other host-...
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ftdoajarticles:oai:doaj.org/article:a2613eea72c14502be51ed15e960df52 2023-05-15T15:11:02+02:00 Host genotype by parasite genotype interactions underlying the resistance of anopheline mosquitoes to Plasmodium falciparum Gouagna Louis C Durand Patrick Halbert Jean Lambrechts Louis Koella Jacob C 2005-01-01T00:00:00Z https://doi.org/10.1186/1475-2875-4-3 https://doaj.org/article/a2613eea72c14502be51ed15e960df52 EN eng BMC http://www.malariajournal.com/content/4/1/3 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-4-3 1475-2875 https://doaj.org/article/a2613eea72c14502be51ed15e960df52 Malaria Journal, Vol 4, Iss 1, p 3 (2005) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2005 ftdoajarticles https://doi.org/10.1186/1475-2875-4-3 2022-12-31T00:04:15Z Abstract Background Most studies on the resistance of mosquitoes to their malaria parasites focus on the response of a mosquito line or colony against a single parasite genotype. In natural situations, however, it may be expected that mosquito-malaria relationships are based, as are many other host-parasite systems, on host genotype by parasite genotype interactions. In such systems, certain hosts are resistant to one subset of the parasite's genotypes, while other hosts are resistant to a different subset. Methods To test for genotype by genotype interactions between malaria parasites and their anopheline vectors, different genetic backgrounds (families consisting of the F1 offspring of individual females) of the major African vector Anopheles gambiae were challenged with several isolates of the human malaria parasite Plasmodium falciparum (obtained from naturally infected children in Kenya). Results Averaged across all parasites, the proportion of infected mosquitoes and the number of oocysts found in their midguts were similar in all mosquito families. Both indices of resistance, however, differed considerably among isolates of the parasite. In particular, no mosquito family was most resistant to all parasites, and no parasite isolate was most infectious to all mosquitoes. Conclusions These results suggest that the level of mosquito resistance depends on the interaction between its own and the parasite's genotype. This finding thus emphasizes the need to take into account the range of genetic diversity exhibited by mosquito and malaria field populations in ideas and studies concerning the control of malaria. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 4 1 3 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Gouagna Louis C Durand Patrick Halbert Jean Lambrechts Louis Koella Jacob C Host genotype by parasite genotype interactions underlying the resistance of anopheline mosquitoes to Plasmodium falciparum |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Most studies on the resistance of mosquitoes to their malaria parasites focus on the response of a mosquito line or colony against a single parasite genotype. In natural situations, however, it may be expected that mosquito-malaria relationships are based, as are many other host-parasite systems, on host genotype by parasite genotype interactions. In such systems, certain hosts are resistant to one subset of the parasite's genotypes, while other hosts are resistant to a different subset. Methods To test for genotype by genotype interactions between malaria parasites and their anopheline vectors, different genetic backgrounds (families consisting of the F1 offspring of individual females) of the major African vector Anopheles gambiae were challenged with several isolates of the human malaria parasite Plasmodium falciparum (obtained from naturally infected children in Kenya). Results Averaged across all parasites, the proportion of infected mosquitoes and the number of oocysts found in their midguts were similar in all mosquito families. Both indices of resistance, however, differed considerably among isolates of the parasite. In particular, no mosquito family was most resistant to all parasites, and no parasite isolate was most infectious to all mosquitoes. Conclusions These results suggest that the level of mosquito resistance depends on the interaction between its own and the parasite's genotype. This finding thus emphasizes the need to take into account the range of genetic diversity exhibited by mosquito and malaria field populations in ideas and studies concerning the control of malaria. |
format |
Article in Journal/Newspaper |
author |
Gouagna Louis C Durand Patrick Halbert Jean Lambrechts Louis Koella Jacob C |
author_facet |
Gouagna Louis C Durand Patrick Halbert Jean Lambrechts Louis Koella Jacob C |
author_sort |
Gouagna Louis C |
title |
Host genotype by parasite genotype interactions underlying the resistance of anopheline mosquitoes to Plasmodium falciparum |
title_short |
Host genotype by parasite genotype interactions underlying the resistance of anopheline mosquitoes to Plasmodium falciparum |
title_full |
Host genotype by parasite genotype interactions underlying the resistance of anopheline mosquitoes to Plasmodium falciparum |
title_fullStr |
Host genotype by parasite genotype interactions underlying the resistance of anopheline mosquitoes to Plasmodium falciparum |
title_full_unstemmed |
Host genotype by parasite genotype interactions underlying the resistance of anopheline mosquitoes to Plasmodium falciparum |
title_sort |
host genotype by parasite genotype interactions underlying the resistance of anopheline mosquitoes to plasmodium falciparum |
publisher |
BMC |
publishDate |
2005 |
url |
https://doi.org/10.1186/1475-2875-4-3 https://doaj.org/article/a2613eea72c14502be51ed15e960df52 |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
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Arctic |
op_source |
Malaria Journal, Vol 4, Iss 1, p 3 (2005) |
op_relation |
http://www.malariajournal.com/content/4/1/3 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-4-3 1475-2875 https://doaj.org/article/a2613eea72c14502be51ed15e960df52 |
op_doi |
https://doi.org/10.1186/1475-2875-4-3 |
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Malaria Journal |
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4 |
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1 |
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3 |
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1766341949766238208 |