Candidatus Neoehrlichia mikurensis and Hepatozoon sp. in voles (Microtus spp.): occurrence and evidence for vertical transmission
Abstract Candidatus Neoehrlichia mikurensis (CNM) and Hepatozoon spp. are important vector-borne parasites of humans and animals. CNM is a relatively recently discovered pathogen of humans. Hepatozoon are parasites of reptiles, amphibians and mammals, commonly found in rodents and carnivores worldwi...
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ftdoajarticles:oai:doaj.org/article:a258000335414663892027f40defeff4 2023-05-15T17:12:37+02:00 Candidatus Neoehrlichia mikurensis and Hepatozoon sp. in voles (Microtus spp.): occurrence and evidence for vertical transmission Katarzyna Tołkacz Maciej Kowalec Mohammed Alsarraf Maciej Grzybek Dorota Dwużnik-Szarek Jerzy M. Behnke Anna Bajer 2023-01-01T00:00:00Z https://doi.org/10.1038/s41598-023-28346-0 https://doaj.org/article/a258000335414663892027f40defeff4 EN eng Nature Portfolio https://doi.org/10.1038/s41598-023-28346-0 https://doaj.org/toc/2045-2322 doi:10.1038/s41598-023-28346-0 2045-2322 https://doaj.org/article/a258000335414663892027f40defeff4 Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023) Medicine R Science Q article 2023 ftdoajarticles https://doi.org/10.1038/s41598-023-28346-0 2023-02-12T01:32:36Z Abstract Candidatus Neoehrlichia mikurensis (CNM) and Hepatozoon spp. are important vector-borne parasites of humans and animals. CNM is a relatively recently discovered pathogen of humans. Hepatozoon are parasites of reptiles, amphibians and mammals, commonly found in rodents and carnivores worldwide. The present study aimed to determine the prevalence of CNM and Hepatozoon spp. in three species of Microtus and to assess the occurrence of vertical transmission in naturally-infected voles. Molecular techniques were used to detect pathogen DNA in blood and tissue samples of captured voles and their offspring. The prevalence of CNM in the vole community ranged 24–47% depending on Microtus species. The DNA of CNM was detected in 21% of pups from three litters of six infected Microtus dams (two Microtus arvalis and one M. oeconomus) and in 3/45 embryos (6.6%) from two litters of eight CNM-infected pregnant females. We detected Hepatozoon infection in 14% of M. arvalis and 9% of M. oeconomus voles. Hepatozoon sp. DNA was detected in 48.7% of pups from seven litters (6 M. arvalis and 1 M. oeconomus) and in two embryos (14.3%) obtained from one M. arvalis litter. The high prevalence of CNM infections in the Microtus spp. community may be a result of a relatively high rate of vertical transmission among naturally infected voles. Vertical transmission was also demonstrated for Hepatozoon sp. in M. arvalis and M. oeconomus. Our study underlines the significance of alternative routes of transmission of important vector-borne pathogens. Article in Journal/Newspaper Microtus arvalis Directory of Open Access Journals: DOAJ Articles Scientific Reports 13 1 |
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Medicine R Science Q Katarzyna Tołkacz Maciej Kowalec Mohammed Alsarraf Maciej Grzybek Dorota Dwużnik-Szarek Jerzy M. Behnke Anna Bajer Candidatus Neoehrlichia mikurensis and Hepatozoon sp. in voles (Microtus spp.): occurrence and evidence for vertical transmission |
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Medicine R Science Q |
description |
Abstract Candidatus Neoehrlichia mikurensis (CNM) and Hepatozoon spp. are important vector-borne parasites of humans and animals. CNM is a relatively recently discovered pathogen of humans. Hepatozoon are parasites of reptiles, amphibians and mammals, commonly found in rodents and carnivores worldwide. The present study aimed to determine the prevalence of CNM and Hepatozoon spp. in three species of Microtus and to assess the occurrence of vertical transmission in naturally-infected voles. Molecular techniques were used to detect pathogen DNA in blood and tissue samples of captured voles and their offspring. The prevalence of CNM in the vole community ranged 24–47% depending on Microtus species. The DNA of CNM was detected in 21% of pups from three litters of six infected Microtus dams (two Microtus arvalis and one M. oeconomus) and in 3/45 embryos (6.6%) from two litters of eight CNM-infected pregnant females. We detected Hepatozoon infection in 14% of M. arvalis and 9% of M. oeconomus voles. Hepatozoon sp. DNA was detected in 48.7% of pups from seven litters (6 M. arvalis and 1 M. oeconomus) and in two embryos (14.3%) obtained from one M. arvalis litter. The high prevalence of CNM infections in the Microtus spp. community may be a result of a relatively high rate of vertical transmission among naturally infected voles. Vertical transmission was also demonstrated for Hepatozoon sp. in M. arvalis and M. oeconomus. Our study underlines the significance of alternative routes of transmission of important vector-borne pathogens. |
format |
Article in Journal/Newspaper |
author |
Katarzyna Tołkacz Maciej Kowalec Mohammed Alsarraf Maciej Grzybek Dorota Dwużnik-Szarek Jerzy M. Behnke Anna Bajer |
author_facet |
Katarzyna Tołkacz Maciej Kowalec Mohammed Alsarraf Maciej Grzybek Dorota Dwużnik-Szarek Jerzy M. Behnke Anna Bajer |
author_sort |
Katarzyna Tołkacz |
title |
Candidatus Neoehrlichia mikurensis and Hepatozoon sp. in voles (Microtus spp.): occurrence and evidence for vertical transmission |
title_short |
Candidatus Neoehrlichia mikurensis and Hepatozoon sp. in voles (Microtus spp.): occurrence and evidence for vertical transmission |
title_full |
Candidatus Neoehrlichia mikurensis and Hepatozoon sp. in voles (Microtus spp.): occurrence and evidence for vertical transmission |
title_fullStr |
Candidatus Neoehrlichia mikurensis and Hepatozoon sp. in voles (Microtus spp.): occurrence and evidence for vertical transmission |
title_full_unstemmed |
Candidatus Neoehrlichia mikurensis and Hepatozoon sp. in voles (Microtus spp.): occurrence and evidence for vertical transmission |
title_sort |
candidatus neoehrlichia mikurensis and hepatozoon sp. in voles (microtus spp.): occurrence and evidence for vertical transmission |
publisher |
Nature Portfolio |
publishDate |
2023 |
url |
https://doi.org/10.1038/s41598-023-28346-0 https://doaj.org/article/a258000335414663892027f40defeff4 |
genre |
Microtus arvalis |
genre_facet |
Microtus arvalis |
op_source |
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023) |
op_relation |
https://doi.org/10.1038/s41598-023-28346-0 https://doaj.org/toc/2045-2322 doi:10.1038/s41598-023-28346-0 2045-2322 https://doaj.org/article/a258000335414663892027f40defeff4 |
op_doi |
https://doi.org/10.1038/s41598-023-28346-0 |
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Scientific Reports |
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13 |
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1 |
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1766069406183456768 |