Dual function of eosinophils in pathogenesis and protective immunity against parasites
The functional duality of eosinophils, involved in a protective response or in pathogenesis is illustrated in various parasitic infections. In schistosomiasis, eosinophils have been shown to mediate schistosomula killing, in the presence of antibodies. The association of eosinophil-dependent cytotox...
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Instituto Oswaldo Cruz, Ministério da Saúde
1992
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ftdoajarticles:oai:doaj.org/article:a21497fb77534967a3a32e3c5a9ae16f 2023-05-15T15:09:00+02:00 Dual function of eosinophils in pathogenesis and protective immunity against parasites Monique Capron 1992-01-01T00:00:00Z https://doi.org/10.1590/S0074-02761992000900012 https://doaj.org/article/a21497fb77534967a3a32e3c5a9ae16f EN eng Instituto Oswaldo Cruz, Ministério da Saúde http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000900012 https://doaj.org/toc/0074-0276 https://doaj.org/toc/1678-8060 doi:10.1590/S0074-02761992000900012 0074-0276 1678-8060 https://doaj.org/article/a21497fb77534967a3a32e3c5a9ae16f Memórias do Instituto Oswaldo Cruz., Vol 87, Pp 83-89 (1992) eosinophils schistosomiasis protection cytotoxicity IL-5 Arctic medicine. Tropical medicine RC955-962 Microbiology QR1-502 article 1992 ftdoajarticles https://doi.org/10.1590/S0074-02761992000900012 2023-01-08T01:39:19Z The functional duality of eosinophils, involved in a protective response or in pathogenesis is illustrated in various parasitic infections. In schistosomiasis, eosinophils have been shown to mediate schistosomula killing, in the presence of antibodies. The association of eosinophil-dependent cytotoxic antibody isotypes with resistance of reinfection (IgE and IgA antibodies), whereas in vitro blocking antibody isotypes (IgG4, IgM) were detected in susceptible subjects, suggested a participation of eosinophils in antibody-dependent protective response. However eosinophils could participate to granuloma formation and consequently to the pathological reactions during schistosomiasis. Activation of eosinophils by antibodies, leading to release of granule proteins have been studied in patients with filariasis. Eosinophil peroxidase, EPO was released safter IgE-dependent activation whereas Eosinophil Cationic Protein, ECP, was released after IgG- and IgA-dependent activation of eosinophils, results suggesting a process of differential release mediators. Interactions between eosinophils and interleukins, and specially IL-5 are discussed. Whereas a receptor for IL-5 has been characterized on human eosinophils, recent studies have shown that eosinophils, expressed the messenger RNA encoding IL-5. These results associated to data showing the synthesis of other cytokines indicate that eosinophils are not only the source of cytotoxic mediators involved in the effector phase of immunity but also of growth and regualtory factors, participating to immunoregulation. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Memórias do Instituto Oswaldo Cruz 87 suppl 5 83 89 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
eosinophils schistosomiasis protection cytotoxicity IL-5 Arctic medicine. Tropical medicine RC955-962 Microbiology QR1-502 |
spellingShingle |
eosinophils schistosomiasis protection cytotoxicity IL-5 Arctic medicine. Tropical medicine RC955-962 Microbiology QR1-502 Monique Capron Dual function of eosinophils in pathogenesis and protective immunity against parasites |
topic_facet |
eosinophils schistosomiasis protection cytotoxicity IL-5 Arctic medicine. Tropical medicine RC955-962 Microbiology QR1-502 |
description |
The functional duality of eosinophils, involved in a protective response or in pathogenesis is illustrated in various parasitic infections. In schistosomiasis, eosinophils have been shown to mediate schistosomula killing, in the presence of antibodies. The association of eosinophil-dependent cytotoxic antibody isotypes with resistance of reinfection (IgE and IgA antibodies), whereas in vitro blocking antibody isotypes (IgG4, IgM) were detected in susceptible subjects, suggested a participation of eosinophils in antibody-dependent protective response. However eosinophils could participate to granuloma formation and consequently to the pathological reactions during schistosomiasis. Activation of eosinophils by antibodies, leading to release of granule proteins have been studied in patients with filariasis. Eosinophil peroxidase, EPO was released safter IgE-dependent activation whereas Eosinophil Cationic Protein, ECP, was released after IgG- and IgA-dependent activation of eosinophils, results suggesting a process of differential release mediators. Interactions between eosinophils and interleukins, and specially IL-5 are discussed. Whereas a receptor for IL-5 has been characterized on human eosinophils, recent studies have shown that eosinophils, expressed the messenger RNA encoding IL-5. These results associated to data showing the synthesis of other cytokines indicate that eosinophils are not only the source of cytotoxic mediators involved in the effector phase of immunity but also of growth and regualtory factors, participating to immunoregulation. |
format |
Article in Journal/Newspaper |
author |
Monique Capron |
author_facet |
Monique Capron |
author_sort |
Monique Capron |
title |
Dual function of eosinophils in pathogenesis and protective immunity against parasites |
title_short |
Dual function of eosinophils in pathogenesis and protective immunity against parasites |
title_full |
Dual function of eosinophils in pathogenesis and protective immunity against parasites |
title_fullStr |
Dual function of eosinophils in pathogenesis and protective immunity against parasites |
title_full_unstemmed |
Dual function of eosinophils in pathogenesis and protective immunity against parasites |
title_sort |
dual function of eosinophils in pathogenesis and protective immunity against parasites |
publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
publishDate |
1992 |
url |
https://doi.org/10.1590/S0074-02761992000900012 https://doaj.org/article/a21497fb77534967a3a32e3c5a9ae16f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Memórias do Instituto Oswaldo Cruz., Vol 87, Pp 83-89 (1992) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000900012 https://doaj.org/toc/0074-0276 https://doaj.org/toc/1678-8060 doi:10.1590/S0074-02761992000900012 0074-0276 1678-8060 https://doaj.org/article/a21497fb77534967a3a32e3c5a9ae16f |
op_doi |
https://doi.org/10.1590/S0074-02761992000900012 |
container_title |
Memórias do Instituto Oswaldo Cruz |
container_volume |
87 |
container_issue |
suppl 5 |
container_start_page |
83 |
op_container_end_page |
89 |
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1766340257671806976 |