Oxidative Stress and Musculoskeletal Pain in University Students with Generalized Joint Hypermobility: A Case–Control Study

• Main Authors: Alghadir AH, Gabr SA, Al-Ghadir M
• Format: Article in Journal/Newspaper
• Language: English
• Published: Dove Medical Press 2021
• Subjects: generalized joint hypermobility; prolidase activity; hydroxyproline; oxidative stress; Medicine (General); R5-920; Tac; sami
• Online Access: https://doaj.org/article/a1fdbdd6e95d4173b8c25e6b8f813089

Ahmad H Alghadir,1 Sami A Gabr,1,2 Muaz Al-Ghadir3 1Rehabilitation Research Chair, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia; 2Department of Anatomy, Faculty of Medicine, Mansoura University, Mansoura, Egypt; 3Department of Orthopedics, King Fahad Medical City, Riyadh, Kingdom of Saudi ArabiaCorrespondence: Sami A GabrRehabilitation Research Chair, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi ArabiaTel [phone]Fax [phone]Email [e-mail]: The current case–control study aimed to evaluate generalized joint hypermobility (GJH) and its association with pain intensity, cellular oxidative stress, and collagen-associated disorders in university students aged 18– 25 years old.Background: Joint hypermobility has been recognized in healthy subjects and people who are carriers of cellular disorders in connective tissues. Cellular tissue oxidative stress and collagen-associated disorders were shown to be associated with joint hypermobility (JH).Materials and Methods: A total of 300 university students aged 18– 25 years were randomly invited from different medical and science faculties in Mansoura university, Mansoura, Egypt to participate in this case–control study. Only 280 university students who had no exclusion criteria like chronic health problems, physical disability, musculoskeletal disorders, and body mass index (BMI) of ≥ 25 underwent an initial clinical interview and Beighton scoring as measures of GJH. Pain intensity, physical activity, oxidative stress parameters; TAC, TOC, OSI, and collagen-associated parameters; cellular prolidase activity and hydroxyproline were evaluated by using a prevalidated questionnaire, colorimetric, and immunoassay techniques.Results: GJH was significantly reported in 57.1% of the study population, and most of them are females. Compared to men, females with GJH showed poor physical activity, lower TAC, and significantly higher levels of TOC, OSI, cellular prolidase ...