Dietary isoflavones, the modulator of breast carcinogenesis: Current landscape and future perspectives
Breast cancer is a frightful disease and serious concern in women around the world causing significant health care burden in both developed and developing countries. Extensive research work has shown that breast cancer provides strong resistance to chemical agents, UV radiation, and hormonal treatme...
Published in: | Asian Pacific Journal of Tropical Medicine |
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ftdoajarticles:oai:doaj.org/article:a1fd83edf2654d2b90e8a0f59b0d2688 2023-05-15T15:10:30+02:00 Dietary isoflavones, the modulator of breast carcinogenesis: Current landscape and future perspectives Javed Iqbal Banzeer Ahsan Abbasi Ali Talha Khalil Barkat Ali Tariq Mahmood Sobia Kanwal Sayed Afzal Shah Wajid Ali 2018-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.228432 https://doaj.org/article/a1fd83edf2654d2b90e8a0f59b0d2688 EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=3;spage=186;epage=193;aulast=Iqbal https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.228432 https://doaj.org/article/a1fd83edf2654d2b90e8a0f59b0d2688 Asian Pacific Journal of Tropical Medicine, Vol 11, Iss 3, Pp 186-193 (2018) dietary isoflavones breast cancer signaling pathways natural phytoestrogens Arctic medicine. Tropical medicine RC955-962 article 2018 ftdoajarticles https://doi.org/10.4103/1995-7645.228432 2022-12-31T03:25:37Z Breast cancer is a frightful disease and serious concern in women around the world causing significant health care burden in both developed and developing countries. Extensive research work has shown that breast cancer provides strong resistance to chemical agents, UV radiation, and hormonal treatments. It is generally accepted that cell genetics is not the only main reason for breast cancer and genetic risk factors, for example, mutations in BRCA1 and BRCA2 genes constitute 5%-10% of all breast cancer rates. Other related factors include age, gender, race, ethnicity, weight, reproductive factors, exo- and endogenous hormonal exposures, oral contraceptives use, ultraviolet radiation, diet, and night work (circadian disruption). Many studies have revealed that dietary isoflavones regulate breast cancer occurrence, recurrence and prognosis. Dietary isoflavones have long been part of Asian population diet and there is a significant increase as compared to dietary isoflavones intake among other populations. Dietary isoflavones are natural phytoestrogens having both estrogenic and anti-estrogenic potentials on breast cancer cells in culture, animal models and in experimental trials. This literature survey provides a comprehensive overview on the tumor preventive and tumor promoting potentials of dietary isoflavones on breast cancer. In addition, this paper provides a literature review of dietary isoflavones and their effects on up-regulation and down-regulation of different signaling pathways, genes and proteins. Finally, future perspectives of dietary isoflavones and breast cancer researchers are also critically discussed, which will provide a deeper insight regarding the inner molecular mechanisms of action. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 11 3 186 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
dietary isoflavones breast cancer signaling pathways natural phytoestrogens Arctic medicine. Tropical medicine RC955-962 |
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dietary isoflavones breast cancer signaling pathways natural phytoestrogens Arctic medicine. Tropical medicine RC955-962 Javed Iqbal Banzeer Ahsan Abbasi Ali Talha Khalil Barkat Ali Tariq Mahmood Sobia Kanwal Sayed Afzal Shah Wajid Ali Dietary isoflavones, the modulator of breast carcinogenesis: Current landscape and future perspectives |
topic_facet |
dietary isoflavones breast cancer signaling pathways natural phytoestrogens Arctic medicine. Tropical medicine RC955-962 |
description |
Breast cancer is a frightful disease and serious concern in women around the world causing significant health care burden in both developed and developing countries. Extensive research work has shown that breast cancer provides strong resistance to chemical agents, UV radiation, and hormonal treatments. It is generally accepted that cell genetics is not the only main reason for breast cancer and genetic risk factors, for example, mutations in BRCA1 and BRCA2 genes constitute 5%-10% of all breast cancer rates. Other related factors include age, gender, race, ethnicity, weight, reproductive factors, exo- and endogenous hormonal exposures, oral contraceptives use, ultraviolet radiation, diet, and night work (circadian disruption). Many studies have revealed that dietary isoflavones regulate breast cancer occurrence, recurrence and prognosis. Dietary isoflavones have long been part of Asian population diet and there is a significant increase as compared to dietary isoflavones intake among other populations. Dietary isoflavones are natural phytoestrogens having both estrogenic and anti-estrogenic potentials on breast cancer cells in culture, animal models and in experimental trials. This literature survey provides a comprehensive overview on the tumor preventive and tumor promoting potentials of dietary isoflavones on breast cancer. In addition, this paper provides a literature review of dietary isoflavones and their effects on up-regulation and down-regulation of different signaling pathways, genes and proteins. Finally, future perspectives of dietary isoflavones and breast cancer researchers are also critically discussed, which will provide a deeper insight regarding the inner molecular mechanisms of action. |
format |
Article in Journal/Newspaper |
author |
Javed Iqbal Banzeer Ahsan Abbasi Ali Talha Khalil Barkat Ali Tariq Mahmood Sobia Kanwal Sayed Afzal Shah Wajid Ali |
author_facet |
Javed Iqbal Banzeer Ahsan Abbasi Ali Talha Khalil Barkat Ali Tariq Mahmood Sobia Kanwal Sayed Afzal Shah Wajid Ali |
author_sort |
Javed Iqbal |
title |
Dietary isoflavones, the modulator of breast carcinogenesis: Current landscape and future perspectives |
title_short |
Dietary isoflavones, the modulator of breast carcinogenesis: Current landscape and future perspectives |
title_full |
Dietary isoflavones, the modulator of breast carcinogenesis: Current landscape and future perspectives |
title_fullStr |
Dietary isoflavones, the modulator of breast carcinogenesis: Current landscape and future perspectives |
title_full_unstemmed |
Dietary isoflavones, the modulator of breast carcinogenesis: Current landscape and future perspectives |
title_sort |
dietary isoflavones, the modulator of breast carcinogenesis: current landscape and future perspectives |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2018 |
url |
https://doi.org/10.4103/1995-7645.228432 https://doaj.org/article/a1fd83edf2654d2b90e8a0f59b0d2688 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 11, Iss 3, Pp 186-193 (2018) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=3;spage=186;epage=193;aulast=Iqbal https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.228432 https://doaj.org/article/a1fd83edf2654d2b90e8a0f59b0d2688 |
op_doi |
https://doi.org/10.4103/1995-7645.228432 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
11 |
container_issue |
3 |
container_start_page |
186 |
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1766341524163919872 |