Frequency of the Risk A Allele of rs17713054 Localized in the 3p21.31 COVID-19 Risk Locus in the Yakut Population

• Published in: International Journal of Biomedicine
• Main Authors: Nadezhda I. Pavlova, Aleksey A. Bochurov, Vladislav A. Alekseev, Aleksandra T. Diakonova, Vladimir V. Dodokhov, Khariton A. Kurtanov
• Format: Article in Journal/Newspaper
• Language: English
• Published: International Medical Research and Development Corporation 2022
• Subjects: sars-cov-2; rs17713054; epithelial-mesenchymal transition; leucine zipper transcription factor like 1; Medicine; R; Yakuts
• Online Access: https://doi.org/10.21103/Article12(1)_OA19; https://doaj.org/article/a1ed268956904b228a31c1a49391d3c3

Background: Genome-wide association studies identified the region of chromosome 3p21.31 as having the strongest association with the severe COVID-19 and susceptibility to SARS-CoV-2 infection. The aim of our study was to investigate the frequency of the risk A allele of rs17713054 localized in the 3p21.31 COVID-19 risk locus in Yakuts. Methods and Results: A total of 382 DNA samples from healthy Yakut volunteers (184 men and 198 women; the average age of 41.8±0.05 years) were examined. Our results show that the frequency of the risk A allele of the rs17713054 SNP in the Yakut population occurs at a frequency of 2% and generally corresponds to the frequency of East Asian populations (from 0% to 2%), geographically close to the Yakuts and belonging to the same Mongoloid race.