Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from 2016 to 2018.
Yellow fever (YF) is endemic in the Brazilian Amazon Basin, and sporadic outbreaks take place outside the endemic area in Brazil. Since 2016, YF epidemics have been occurring in Southeast Brazil, with more than 1,900 human cases and more than 1,600 epizooties of non-human primates (NHPs) reported un...
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ftdoajarticles:oai:doaj.org/article:a1bb76fbbd324f8aae960fb9c5a005a8 2023-05-15T15:18:23+02:00 Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from 2016 to 2018. Izabela Maurício de Rezende Lívia Sacchetto Érica Munhoz de Mello Pedro Augusto Alves Felipe Campos de Melo Iani Talita Émile Ribeiro Adelino Myrian Morato Duarte Ana Luísa Furtado Cury André Felipe Leal Bernardes Tayrine Araújo Santos Leonardo Soares Pereira Maria Rita Teixeira Dutra Dario Brock Ramalho Benoit de Thoisy Erna Geessien Kroon Giliane de Souza Trindade Betânia Paiva Drumond 2018-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006538 https://doaj.org/article/a1bb76fbbd324f8aae960fb9c5a005a8 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC6002110?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006538 https://doaj.org/article/a1bb76fbbd324f8aae960fb9c5a005a8 PLoS Neglected Tropical Diseases, Vol 12, Iss 6, p e0006538 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006538 2022-12-31T13:30:15Z Yellow fever (YF) is endemic in the Brazilian Amazon Basin, and sporadic outbreaks take place outside the endemic area in Brazil. Since 2016, YF epidemics have been occurring in Southeast Brazil, with more than 1,900 human cases and more than 1,600 epizooties of non-human primates (NHPs) reported until April 2018. Previous studies have demonstrated that Yellow fever virus (YFV) causing outbreaks in 2017 formed a monophyletic group.Aiming to decipher the origin of the YFV responsible for the recent epidemics, we obtained nucleotide sequences of YFV detected in humans (n = 6) and NHPs (n = 10) from Minas Gerais state during 2017-2018. Next, we performed evolutionary analyses and discussed the results in the light of epidemiological records (official numbers of YFV cases at each Brazilian Federative unit, reported by the Brazilian Ministry of Health). Nucleotide sequences of YFV from Southeast Brazil from 2016 to 2018 were highly conserved and formed a monophyletic lineage (BR-YFV_2016/18) within the genotype South America I. Different clusters were observed within lineage BR-YFV_2016/18, one containing the majority of isolates (from humans and NHPs), indicating the sylvatic transmission of YFV. We also detected a cluster characterized by two synapomorphies (amino acid substitutions) that contained YFV only associated with NHP what should be further investigated. The topology of lineage BR-YFV_2016/18 was congruent with epidemiological and temporal patterns of the ongoing epidemic. YFV isolates detected in 2016, in São Paulo state were located in the most basal position of the lineage, followed by the isolates from Minas Gerais and Espírito Santo obtained in 2017 and 2018. The most recent common ancestor of the lineage BR-YFV_2016/18 dated to 2015 (95% credible intervals = 2014-2016), in a period that was coincident with the reemergence of YFV in the Midwest region of Brazil.The results demonstrated a single introduction of YFV in the Southeast region and the silent viral circulation before the onset of the ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 12 6 e0006538 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Izabela Maurício de Rezende Lívia Sacchetto Érica Munhoz de Mello Pedro Augusto Alves Felipe Campos de Melo Iani Talita Émile Ribeiro Adelino Myrian Morato Duarte Ana Luísa Furtado Cury André Felipe Leal Bernardes Tayrine Araújo Santos Leonardo Soares Pereira Maria Rita Teixeira Dutra Dario Brock Ramalho Benoit de Thoisy Erna Geessien Kroon Giliane de Souza Trindade Betânia Paiva Drumond Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from 2016 to 2018. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Yellow fever (YF) is endemic in the Brazilian Amazon Basin, and sporadic outbreaks take place outside the endemic area in Brazil. Since 2016, YF epidemics have been occurring in Southeast Brazil, with more than 1,900 human cases and more than 1,600 epizooties of non-human primates (NHPs) reported until April 2018. Previous studies have demonstrated that Yellow fever virus (YFV) causing outbreaks in 2017 formed a monophyletic group.Aiming to decipher the origin of the YFV responsible for the recent epidemics, we obtained nucleotide sequences of YFV detected in humans (n = 6) and NHPs (n = 10) from Minas Gerais state during 2017-2018. Next, we performed evolutionary analyses and discussed the results in the light of epidemiological records (official numbers of YFV cases at each Brazilian Federative unit, reported by the Brazilian Ministry of Health). Nucleotide sequences of YFV from Southeast Brazil from 2016 to 2018 were highly conserved and formed a monophyletic lineage (BR-YFV_2016/18) within the genotype South America I. Different clusters were observed within lineage BR-YFV_2016/18, one containing the majority of isolates (from humans and NHPs), indicating the sylvatic transmission of YFV. We also detected a cluster characterized by two synapomorphies (amino acid substitutions) that contained YFV only associated with NHP what should be further investigated. The topology of lineage BR-YFV_2016/18 was congruent with epidemiological and temporal patterns of the ongoing epidemic. YFV isolates detected in 2016, in São Paulo state were located in the most basal position of the lineage, followed by the isolates from Minas Gerais and Espírito Santo obtained in 2017 and 2018. The most recent common ancestor of the lineage BR-YFV_2016/18 dated to 2015 (95% credible intervals = 2014-2016), in a period that was coincident with the reemergence of YFV in the Midwest region of Brazil.The results demonstrated a single introduction of YFV in the Southeast region and the silent viral circulation before the onset of the ... |
format |
Article in Journal/Newspaper |
author |
Izabela Maurício de Rezende Lívia Sacchetto Érica Munhoz de Mello Pedro Augusto Alves Felipe Campos de Melo Iani Talita Émile Ribeiro Adelino Myrian Morato Duarte Ana Luísa Furtado Cury André Felipe Leal Bernardes Tayrine Araújo Santos Leonardo Soares Pereira Maria Rita Teixeira Dutra Dario Brock Ramalho Benoit de Thoisy Erna Geessien Kroon Giliane de Souza Trindade Betânia Paiva Drumond |
author_facet |
Izabela Maurício de Rezende Lívia Sacchetto Érica Munhoz de Mello Pedro Augusto Alves Felipe Campos de Melo Iani Talita Émile Ribeiro Adelino Myrian Morato Duarte Ana Luísa Furtado Cury André Felipe Leal Bernardes Tayrine Araújo Santos Leonardo Soares Pereira Maria Rita Teixeira Dutra Dario Brock Ramalho Benoit de Thoisy Erna Geessien Kroon Giliane de Souza Trindade Betânia Paiva Drumond |
author_sort |
Izabela Maurício de Rezende |
title |
Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from 2016 to 2018. |
title_short |
Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from 2016 to 2018. |
title_full |
Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from 2016 to 2018. |
title_fullStr |
Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from 2016 to 2018. |
title_full_unstemmed |
Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from 2016 to 2018. |
title_sort |
persistence of yellow fever virus outside the amazon basin, causing epidemics in southeast brazil, from 2016 to 2018. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006538 https://doaj.org/article/a1bb76fbbd324f8aae960fb9c5a005a8 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 6, p e0006538 (2018) |
op_relation |
http://europepmc.org/articles/PMC6002110?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006538 https://doaj.org/article/a1bb76fbbd324f8aae960fb9c5a005a8 |
op_doi |
https://doi.org/10.1371/journal.pntd.0006538 |
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PLOS Neglected Tropical Diseases |
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12 |
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6 |
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e0006538 |
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