Manifestations of Fasting-Induced Fatty Liver and Rapid Recovery from Steatosis in Voles Fed Lard or Flaxseed Oil Lipids
Long-chain n-3 polyunsaturated fatty acids (PUFA) can have beneficial effects against fat deposition, cardiovascular diseases, and liver steatosis. We investigated how diets based on lard (predominantly saturated and monounsaturated fatty acids) or flaxseed oil (rich in 18:3n-3) affect liver fat-% a...
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ftdoajarticles:oai:doaj.org/article:a1b33ea53289455d9faf4ae3e14877fa 2023-05-15T18:40:33+02:00 Manifestations of Fasting-Induced Fatty Liver and Rapid Recovery from Steatosis in Voles Fed Lard or Flaxseed Oil Lipids Toivo Halonen Kirsti Rouvinen-Watt Markku Tammi Raija Tammi Michael Kilpiö Anne-Mari Mustonen Vesa Kärjä Petteri Nieminen 2013-10-01T00:00:00Z https://doi.org/10.3390/nu5104211 https://doaj.org/article/a1b33ea53289455d9faf4ae3e14877fa EN eng MDPI AG http://www.mdpi.com/2072-6643/5/10/4211 https://doaj.org/toc/2072-6643 doi:10.3390/nu5104211 2072-6643 https://doaj.org/article/a1b33ea53289455d9faf4ae3e14877fa Nutrients, Vol 5, Iss 10, Pp 4211-4230 (2013) fasting fatty liver flaxseed oil hyaluronan lard α-linolenic acid Microtus voles n-3 PUFA SFA steatosis Nutrition. Foods and food supply TX341-641 article 2013 ftdoajarticles https://doi.org/10.3390/nu5104211 2022-12-31T16:00:53Z Long-chain n-3 polyunsaturated fatty acids (PUFA) can have beneficial effects against fat deposition, cardiovascular diseases, and liver steatosis. We investigated how diets based on lard (predominantly saturated and monounsaturated fatty acids) or flaxseed oil (rich in 18:3n-3) affect liver fat-% and fatty acid profiles of tundra voles (Microtus oeconomus). We also studied potential participation of hyaluronan (HA) in the pathology of fatty liver and whether the development and recovery of fasting-induced steatosis are influenced by n-3 PUFA. The dietary fatty acid composition was manifested in the liver fatty acid signatures. Fasting for 18 h induced macrovesicular steatosis and the liver fat-% increased to 22% independent of the preceding diet. Fasting-induced steatosis did not involve inflammation or connective tissue activation indicated by the absence of both leukocyte accumulation and increased HA. Food deprivation modified the liver fatty acid signatures to resemble more closely the diets. Fasting reduced the proportions of long-chain n-3 PUFA in both dietary regimes and n-3/n-6 PUFA ratios in the lard-fed voles. Decreases in long-chain n-3 PUFA may promote lipid accumulation by modulating the expression of lipid-metabolizing genes. Dietary 18:3n-3 did not prevent the development or attenuate the manifestation of steatosis in the fasted voles or promote the recovery. Article in Journal/Newspaper Tundra Directory of Open Access Journals: DOAJ Articles Nutrients 5 10 4211 4230 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
fasting fatty liver flaxseed oil hyaluronan lard α-linolenic acid Microtus voles n-3 PUFA SFA steatosis Nutrition. Foods and food supply TX341-641 |
spellingShingle |
fasting fatty liver flaxseed oil hyaluronan lard α-linolenic acid Microtus voles n-3 PUFA SFA steatosis Nutrition. Foods and food supply TX341-641 Toivo Halonen Kirsti Rouvinen-Watt Markku Tammi Raija Tammi Michael Kilpiö Anne-Mari Mustonen Vesa Kärjä Petteri Nieminen Manifestations of Fasting-Induced Fatty Liver and Rapid Recovery from Steatosis in Voles Fed Lard or Flaxseed Oil Lipids |
topic_facet |
fasting fatty liver flaxseed oil hyaluronan lard α-linolenic acid Microtus voles n-3 PUFA SFA steatosis Nutrition. Foods and food supply TX341-641 |
description |
Long-chain n-3 polyunsaturated fatty acids (PUFA) can have beneficial effects against fat deposition, cardiovascular diseases, and liver steatosis. We investigated how diets based on lard (predominantly saturated and monounsaturated fatty acids) or flaxseed oil (rich in 18:3n-3) affect liver fat-% and fatty acid profiles of tundra voles (Microtus oeconomus). We also studied potential participation of hyaluronan (HA) in the pathology of fatty liver and whether the development and recovery of fasting-induced steatosis are influenced by n-3 PUFA. The dietary fatty acid composition was manifested in the liver fatty acid signatures. Fasting for 18 h induced macrovesicular steatosis and the liver fat-% increased to 22% independent of the preceding diet. Fasting-induced steatosis did not involve inflammation or connective tissue activation indicated by the absence of both leukocyte accumulation and increased HA. Food deprivation modified the liver fatty acid signatures to resemble more closely the diets. Fasting reduced the proportions of long-chain n-3 PUFA in both dietary regimes and n-3/n-6 PUFA ratios in the lard-fed voles. Decreases in long-chain n-3 PUFA may promote lipid accumulation by modulating the expression of lipid-metabolizing genes. Dietary 18:3n-3 did not prevent the development or attenuate the manifestation of steatosis in the fasted voles or promote the recovery. |
format |
Article in Journal/Newspaper |
author |
Toivo Halonen Kirsti Rouvinen-Watt Markku Tammi Raija Tammi Michael Kilpiö Anne-Mari Mustonen Vesa Kärjä Petteri Nieminen |
author_facet |
Toivo Halonen Kirsti Rouvinen-Watt Markku Tammi Raija Tammi Michael Kilpiö Anne-Mari Mustonen Vesa Kärjä Petteri Nieminen |
author_sort |
Toivo Halonen |
title |
Manifestations of Fasting-Induced Fatty Liver and Rapid Recovery from Steatosis in Voles Fed Lard or Flaxseed Oil Lipids |
title_short |
Manifestations of Fasting-Induced Fatty Liver and Rapid Recovery from Steatosis in Voles Fed Lard or Flaxseed Oil Lipids |
title_full |
Manifestations of Fasting-Induced Fatty Liver and Rapid Recovery from Steatosis in Voles Fed Lard or Flaxseed Oil Lipids |
title_fullStr |
Manifestations of Fasting-Induced Fatty Liver and Rapid Recovery from Steatosis in Voles Fed Lard or Flaxseed Oil Lipids |
title_full_unstemmed |
Manifestations of Fasting-Induced Fatty Liver and Rapid Recovery from Steatosis in Voles Fed Lard or Flaxseed Oil Lipids |
title_sort |
manifestations of fasting-induced fatty liver and rapid recovery from steatosis in voles fed lard or flaxseed oil lipids |
publisher |
MDPI AG |
publishDate |
2013 |
url |
https://doi.org/10.3390/nu5104211 https://doaj.org/article/a1b33ea53289455d9faf4ae3e14877fa |
genre |
Tundra |
genre_facet |
Tundra |
op_source |
Nutrients, Vol 5, Iss 10, Pp 4211-4230 (2013) |
op_relation |
http://www.mdpi.com/2072-6643/5/10/4211 https://doaj.org/toc/2072-6643 doi:10.3390/nu5104211 2072-6643 https://doaj.org/article/a1b33ea53289455d9faf4ae3e14877fa |
op_doi |
https://doi.org/10.3390/nu5104211 |
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Nutrients |
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5 |
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10 |
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4211 |
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4230 |
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1766229941771304960 |