Performance of the Rheumatoid Arthritis Impact of Disease (RAID) score in relation to flares in disease activity
Objectives To explore the performance of the EULAR-initiated patient-reported Rheumatoid Arthritis Impact of Disease (RAID) questionnaire in relation to flares in disease activity, including comparison with other disease activity outcomes.Methods Patients with rheumatoid arthritis in sustained remis...
Published in: | RMD Open |
---|---|
Main Authors: | , , , , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMJ Publishing Group
2024
|
Subjects: | |
Online Access: | https://doi.org/10.1136/rmdopen-2023-003486 https://doaj.org/article/a194135dbac9473892ac348f607099d8 |
id |
ftdoajarticles:oai:doaj.org/article:a194135dbac9473892ac348f607099d8 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:a194135dbac9473892ac348f607099d8 2024-02-11T10:01:38+01:00 Performance of the Rheumatoid Arthritis Impact of Disease (RAID) score in relation to flares in disease activity Tore K Kvien Gunnstein Bakland Åse Lexberg Lena Bugge Nordberg Siri Lillegraven Anna-Birgitte Aga Joseph Sexton Till Uhlig Espen A Haavardsholm Karen Holten Daniel H Solomon Maud-Kristine Aga Ljoså Hallvard Fremstad Tor Magne Madland Hilde Haukeland Inger Myrnes Hansen Nina Paulshus Sundlisæter Cristina Spada Christian A Høili IngerJohanne Widding Hansen 2024-01-01T00:00:00Z https://doi.org/10.1136/rmdopen-2023-003486 https://doaj.org/article/a194135dbac9473892ac348f607099d8 EN eng BMJ Publishing Group https://rmdopen.bmj.com/content/10/1/e003486.full https://doaj.org/toc/2056-5933 doi:10.1136/rmdopen-2023-003486 2056-5933 https://doaj.org/article/a194135dbac9473892ac348f607099d8 RMD Open, Vol 10, Iss 1 (2024) Medicine R article 2024 ftdoajarticles https://doi.org/10.1136/rmdopen-2023-003486 2024-01-14T01:37:03Z Objectives To explore the performance of the EULAR-initiated patient-reported Rheumatoid Arthritis Impact of Disease (RAID) questionnaire in relation to flares in disease activity, including comparison with other disease activity outcomes.Methods Patients with rheumatoid arthritis in sustained remission were randomised to continued stable treatment or tapering in the ARCTIC REWIND project. In patients with flares within 12 months, we compared RAID (total score and components) at the flare visit with the visit prior to and the visit following flare, using Wilcoxon signed-rank test. Similar analyses were performed for patient global assessment, Disease Activity Score (DAS) and C reactive protein (CRP). The discriminative accuracies of RAID, patient global assessment, DAS and CRP with respect to disease activity flares were assessed by receiver operating characteristic (ROC) analyses based on logistic regression models. Flare was defined as a combination of DAS >1.6, a DAS increase ≥0.6 and ≥two swollen joints (of 44 examined) or could be recorded if patient and rheumatologist agreed that a clinically significant flare had occurred.Results In total, 248 patients were included in the analyses, with 56 flares. RAID, patient global assessment, DAS and CRP all changed significantly at the visits related to flare (p<0.001). Area under the curve (95% CI) values indicated that RAID (0.88 (0.83 to 0.93)) was significantly more accurate than CRP (0.76 (0.69 to 0.84)) in discriminating flare, and less accurate than patient global assessment (0.92 (0.87 to 0.97)) and DAS (0.94 (0.90 to 0.98)). The RAID components with highest and lowest discriminative accuracies were pain (0.91 (0.86 to 0.95)) and sleep (0.69 (0.59 to 0.79)).Conclusion Disease activity flares were associated with a significant increase in median RAID, supporting its ability to respond to flare.Trial registration number NCT01881308. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic RMD Open 10 1 e003486 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Medicine R |
spellingShingle |
Medicine R Tore K Kvien Gunnstein Bakland Åse Lexberg Lena Bugge Nordberg Siri Lillegraven Anna-Birgitte Aga Joseph Sexton Till Uhlig Espen A Haavardsholm Karen Holten Daniel H Solomon Maud-Kristine Aga Ljoså Hallvard Fremstad Tor Magne Madland Hilde Haukeland Inger Myrnes Hansen Nina Paulshus Sundlisæter Cristina Spada Christian A Høili IngerJohanne Widding Hansen Performance of the Rheumatoid Arthritis Impact of Disease (RAID) score in relation to flares in disease activity |
topic_facet |
Medicine R |
description |
Objectives To explore the performance of the EULAR-initiated patient-reported Rheumatoid Arthritis Impact of Disease (RAID) questionnaire in relation to flares in disease activity, including comparison with other disease activity outcomes.Methods Patients with rheumatoid arthritis in sustained remission were randomised to continued stable treatment or tapering in the ARCTIC REWIND project. In patients with flares within 12 months, we compared RAID (total score and components) at the flare visit with the visit prior to and the visit following flare, using Wilcoxon signed-rank test. Similar analyses were performed for patient global assessment, Disease Activity Score (DAS) and C reactive protein (CRP). The discriminative accuracies of RAID, patient global assessment, DAS and CRP with respect to disease activity flares were assessed by receiver operating characteristic (ROC) analyses based on logistic regression models. Flare was defined as a combination of DAS >1.6, a DAS increase ≥0.6 and ≥two swollen joints (of 44 examined) or could be recorded if patient and rheumatologist agreed that a clinically significant flare had occurred.Results In total, 248 patients were included in the analyses, with 56 flares. RAID, patient global assessment, DAS and CRP all changed significantly at the visits related to flare (p<0.001). Area under the curve (95% CI) values indicated that RAID (0.88 (0.83 to 0.93)) was significantly more accurate than CRP (0.76 (0.69 to 0.84)) in discriminating flare, and less accurate than patient global assessment (0.92 (0.87 to 0.97)) and DAS (0.94 (0.90 to 0.98)). The RAID components with highest and lowest discriminative accuracies were pain (0.91 (0.86 to 0.95)) and sleep (0.69 (0.59 to 0.79)).Conclusion Disease activity flares were associated with a significant increase in median RAID, supporting its ability to respond to flare.Trial registration number NCT01881308. |
format |
Article in Journal/Newspaper |
author |
Tore K Kvien Gunnstein Bakland Åse Lexberg Lena Bugge Nordberg Siri Lillegraven Anna-Birgitte Aga Joseph Sexton Till Uhlig Espen A Haavardsholm Karen Holten Daniel H Solomon Maud-Kristine Aga Ljoså Hallvard Fremstad Tor Magne Madland Hilde Haukeland Inger Myrnes Hansen Nina Paulshus Sundlisæter Cristina Spada Christian A Høili IngerJohanne Widding Hansen |
author_facet |
Tore K Kvien Gunnstein Bakland Åse Lexberg Lena Bugge Nordberg Siri Lillegraven Anna-Birgitte Aga Joseph Sexton Till Uhlig Espen A Haavardsholm Karen Holten Daniel H Solomon Maud-Kristine Aga Ljoså Hallvard Fremstad Tor Magne Madland Hilde Haukeland Inger Myrnes Hansen Nina Paulshus Sundlisæter Cristina Spada Christian A Høili IngerJohanne Widding Hansen |
author_sort |
Tore K Kvien |
title |
Performance of the Rheumatoid Arthritis Impact of Disease (RAID) score in relation to flares in disease activity |
title_short |
Performance of the Rheumatoid Arthritis Impact of Disease (RAID) score in relation to flares in disease activity |
title_full |
Performance of the Rheumatoid Arthritis Impact of Disease (RAID) score in relation to flares in disease activity |
title_fullStr |
Performance of the Rheumatoid Arthritis Impact of Disease (RAID) score in relation to flares in disease activity |
title_full_unstemmed |
Performance of the Rheumatoid Arthritis Impact of Disease (RAID) score in relation to flares in disease activity |
title_sort |
performance of the rheumatoid arthritis impact of disease (raid) score in relation to flares in disease activity |
publisher |
BMJ Publishing Group |
publishDate |
2024 |
url |
https://doi.org/10.1136/rmdopen-2023-003486 https://doaj.org/article/a194135dbac9473892ac348f607099d8 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
RMD Open, Vol 10, Iss 1 (2024) |
op_relation |
https://rmdopen.bmj.com/content/10/1/e003486.full https://doaj.org/toc/2056-5933 doi:10.1136/rmdopen-2023-003486 2056-5933 https://doaj.org/article/a194135dbac9473892ac348f607099d8 |
op_doi |
https://doi.org/10.1136/rmdopen-2023-003486 |
container_title |
RMD Open |
container_volume |
10 |
container_issue |
1 |
container_start_page |
e003486 |
_version_ |
1790597426228232192 |