The epidemiology of human Taenia solium infections: A systematic review of the distribution in Eastern and Southern Africa.
Background Taenia solium is a tapeworm that causes taeniosis in humans and cysticercosis in humans and pigs. Within Eastern and Southern Africa (ESA), information on the presence of human taeniosis and cysticercosis seems scarce. This systematic review aimed to describe the current information avail...
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ftdoajarticles:oai:doaj.org/article:a11676c89dc544b183fd9e8611ad808a 2023-06-11T04:09:57+02:00 The epidemiology of human Taenia solium infections: A systematic review of the distribution in Eastern and Southern Africa. Gideon Zulu Dominik Stelzle Kabemba E Mwape Tamara M Welte Hilde Strømme Chishimba Mubanga Wilbroad Mutale Annette Abraham Alex Hachangu Veronika Schmidt Chummy S Sikasunge Isaac K Phiri Andrea S Winkler 2023-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0011042 https://doaj.org/article/a11676c89dc544b183fd9e8611ad808a EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0011042 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011042 https://doaj.org/article/a11676c89dc544b183fd9e8611ad808a PLoS Neglected Tropical Diseases, Vol 17, Iss 3, p e0011042 (2023) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2023 ftdoajarticles https://doi.org/10.1371/journal.pntd.0011042 2023-05-07T00:31:57Z Background Taenia solium is a tapeworm that causes taeniosis in humans and cysticercosis in humans and pigs. Within Eastern and Southern Africa (ESA), information on the presence of human taeniosis and cysticercosis seems scarce. This systematic review aimed to describe the current information available and gaps in the epidemiology of human T. solium infections in ESA. Methods/principle findings Scientific literature published between 1st January 2000 and 20th June 2022 in international databases [MEDLINE (Ovid), Embase (Ovid), Global Health (Ovid), Scopus (Elsevier), African Index Medicus (via WHO Global Index Medicus), and Open Grey] was systematically reviewed for ESA. The study area included 27 countries that make up the ESA region. Information on either taeniosis, cysticercosis or NCC was available for 16 of 27 countries within the region and a total of 113 reports were retained for the review. Most case reports for cysticercosis and NCC were from South Africa, while Tanzania had the most aggregated cysticercosis reports. Eleven countries reported on NCC with seven countries reporting data on NCC and epilepsy. Unconfirmed human T. solium taeniosis cases were reported in nine countries while two countries (Madagascar and Zambia) reported confirmed T. solium cases. The cysticercosis seroprevalence ranged between 0.7-40.8% on antigen (Ag) ELISA and between 13.1-45.3% on antibody (Ab) ELISA. Based on immunoblot tests the Ab seroprevalence was between 1.7-39.3%, while the proportion of NCC-suggestive lesions on brain CT scans was between 1.0-76% depending on the study population. The human taeniosis prevalence based on microscopy ranged between 0.1-14.7%. Based on Copro Ag-ELISA studies conducted in Kenya, Rwanda, Tanzania, and Zambia, the highest prevalence of 19.7% was reported in Kenya. Conclusions Despite the public health and economic impact of T. solium in ESA, there are still large gaps in knowledge about the occurrence of the parasite, and the resulting One Health disease complex, and monitoring of T. ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 17 3 e0011042 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Gideon Zulu Dominik Stelzle Kabemba E Mwape Tamara M Welte Hilde Strømme Chishimba Mubanga Wilbroad Mutale Annette Abraham Alex Hachangu Veronika Schmidt Chummy S Sikasunge Isaac K Phiri Andrea S Winkler The epidemiology of human Taenia solium infections: A systematic review of the distribution in Eastern and Southern Africa. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Taenia solium is a tapeworm that causes taeniosis in humans and cysticercosis in humans and pigs. Within Eastern and Southern Africa (ESA), information on the presence of human taeniosis and cysticercosis seems scarce. This systematic review aimed to describe the current information available and gaps in the epidemiology of human T. solium infections in ESA. Methods/principle findings Scientific literature published between 1st January 2000 and 20th June 2022 in international databases [MEDLINE (Ovid), Embase (Ovid), Global Health (Ovid), Scopus (Elsevier), African Index Medicus (via WHO Global Index Medicus), and Open Grey] was systematically reviewed for ESA. The study area included 27 countries that make up the ESA region. Information on either taeniosis, cysticercosis or NCC was available for 16 of 27 countries within the region and a total of 113 reports were retained for the review. Most case reports for cysticercosis and NCC were from South Africa, while Tanzania had the most aggregated cysticercosis reports. Eleven countries reported on NCC with seven countries reporting data on NCC and epilepsy. Unconfirmed human T. solium taeniosis cases were reported in nine countries while two countries (Madagascar and Zambia) reported confirmed T. solium cases. The cysticercosis seroprevalence ranged between 0.7-40.8% on antigen (Ag) ELISA and between 13.1-45.3% on antibody (Ab) ELISA. Based on immunoblot tests the Ab seroprevalence was between 1.7-39.3%, while the proportion of NCC-suggestive lesions on brain CT scans was between 1.0-76% depending on the study population. The human taeniosis prevalence based on microscopy ranged between 0.1-14.7%. Based on Copro Ag-ELISA studies conducted in Kenya, Rwanda, Tanzania, and Zambia, the highest prevalence of 19.7% was reported in Kenya. Conclusions Despite the public health and economic impact of T. solium in ESA, there are still large gaps in knowledge about the occurrence of the parasite, and the resulting One Health disease complex, and monitoring of T. ... |
format |
Article in Journal/Newspaper |
author |
Gideon Zulu Dominik Stelzle Kabemba E Mwape Tamara M Welte Hilde Strømme Chishimba Mubanga Wilbroad Mutale Annette Abraham Alex Hachangu Veronika Schmidt Chummy S Sikasunge Isaac K Phiri Andrea S Winkler |
author_facet |
Gideon Zulu Dominik Stelzle Kabemba E Mwape Tamara M Welte Hilde Strømme Chishimba Mubanga Wilbroad Mutale Annette Abraham Alex Hachangu Veronika Schmidt Chummy S Sikasunge Isaac K Phiri Andrea S Winkler |
author_sort |
Gideon Zulu |
title |
The epidemiology of human Taenia solium infections: A systematic review of the distribution in Eastern and Southern Africa. |
title_short |
The epidemiology of human Taenia solium infections: A systematic review of the distribution in Eastern and Southern Africa. |
title_full |
The epidemiology of human Taenia solium infections: A systematic review of the distribution in Eastern and Southern Africa. |
title_fullStr |
The epidemiology of human Taenia solium infections: A systematic review of the distribution in Eastern and Southern Africa. |
title_full_unstemmed |
The epidemiology of human Taenia solium infections: A systematic review of the distribution in Eastern and Southern Africa. |
title_sort |
epidemiology of human taenia solium infections: a systematic review of the distribution in eastern and southern africa. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2023 |
url |
https://doi.org/10.1371/journal.pntd.0011042 https://doaj.org/article/a11676c89dc544b183fd9e8611ad808a |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 17, Iss 3, p e0011042 (2023) |
op_relation |
https://doi.org/10.1371/journal.pntd.0011042 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011042 https://doaj.org/article/a11676c89dc544b183fd9e8611ad808a |
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https://doi.org/10.1371/journal.pntd.0011042 |
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PLOS Neglected Tropical Diseases |
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17 |
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3 |
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e0011042 |
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