Estimation of the novel antipyretic, anti-inflammatory, antinociceptive and antihyperlipidemic effects of silymarin in Albino rats and mice
Objective: To evaluate the other pharmacological actions of silymarin in Albino rats and mice such as antipyretic, anti-inflammatory, antinociceptive and antihyperlipidemic effects. Methods: Rats were injected intramuscularly with pyrogenic dose of brewer's yeast for the antipyretic test of sil...
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Wolters Kluwer Medknow Publications
2015
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ftdoajarticles:oai:doaj.org/article:a0a59fe03a064d5980885be06fa60758 2023-05-15T15:13:19+02:00 Estimation of the novel antipyretic, anti-inflammatory, antinociceptive and antihyperlipidemic effects of silymarin in Albino rats and mice Mohamed Mahmoud Amin Mahmoud Soliman Arbid 2015-08-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2015.05.009 https://doaj.org/article/a0a59fe03a064d5980885be06fa60758 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115001070 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.05.009 https://doaj.org/article/a0a59fe03a064d5980885be06fa60758 Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 8, Pp 619-623 (2015) Silymarin Antipyretic Anti-inflammatory Antinociceptive Antihyperlipidemic Albino rats Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2015 ftdoajarticles https://doi.org/10.1016/j.apjtb.2015.05.009 2022-12-31T05:46:37Z Objective: To evaluate the other pharmacological actions of silymarin in Albino rats and mice such as antipyretic, anti-inflammatory, antinociceptive and antihyperlipidemic effects. Methods: Rats were injected intramuscularly with pyrogenic dose of brewer's yeast for the antipyretic test of silymarin. Another group of rats injected with 0.1 mL of 1% carrageenan solution in saline at the subplanter area of the right hind paw for the anti-inflammatory test of silymarin. Another group of mice tested by hot plate method for determination of antinociceptive effect of silymarin. Hyperlipidemia was induced using high fat diet for 2 months to estimate the antihyperlipidemic activity of silymarin. Results: Silymarin showed a significant antipyretic effect of both doses (50 and 100 mg/kg) compared with control untreated group. Moreover, silymarin elucidated a significant anti-inflammatory effect of both doses reflected on the decrease of the rat paw edema every hour interval for 4 h after administration in comparison with control positive group. By the same taken, both doses of silymarine revealed a significant antinociceptive action in hot plate method at 30 and 60 min post administration. Besides, it lowered significantly the serum levels of prostaglandin E2, tumor necrosis factor alpha and interleukin 1 beta after 2 h of silymarin administration in carrageenan induced rat paw edema besides the significant decrease of total cholesterol, triglycerides, low density lipoprotein and significantly elevated high density lipoprotein after 2 weeks of silymarin administration. Conclusions: These outcomes delivered a new vision into the possible pharmacological mechanisms by which silymarin advances antipyretic, anti-inflammatory, antinociceptive and antihyperlipidemic effects. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 5 8 619 623 |
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topic |
Silymarin Antipyretic Anti-inflammatory Antinociceptive Antihyperlipidemic Albino rats Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
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Silymarin Antipyretic Anti-inflammatory Antinociceptive Antihyperlipidemic Albino rats Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Mohamed Mahmoud Amin Mahmoud Soliman Arbid Estimation of the novel antipyretic, anti-inflammatory, antinociceptive and antihyperlipidemic effects of silymarin in Albino rats and mice |
topic_facet |
Silymarin Antipyretic Anti-inflammatory Antinociceptive Antihyperlipidemic Albino rats Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To evaluate the other pharmacological actions of silymarin in Albino rats and mice such as antipyretic, anti-inflammatory, antinociceptive and antihyperlipidemic effects. Methods: Rats were injected intramuscularly with pyrogenic dose of brewer's yeast for the antipyretic test of silymarin. Another group of rats injected with 0.1 mL of 1% carrageenan solution in saline at the subplanter area of the right hind paw for the anti-inflammatory test of silymarin. Another group of mice tested by hot plate method for determination of antinociceptive effect of silymarin. Hyperlipidemia was induced using high fat diet for 2 months to estimate the antihyperlipidemic activity of silymarin. Results: Silymarin showed a significant antipyretic effect of both doses (50 and 100 mg/kg) compared with control untreated group. Moreover, silymarin elucidated a significant anti-inflammatory effect of both doses reflected on the decrease of the rat paw edema every hour interval for 4 h after administration in comparison with control positive group. By the same taken, both doses of silymarine revealed a significant antinociceptive action in hot plate method at 30 and 60 min post administration. Besides, it lowered significantly the serum levels of prostaglandin E2, tumor necrosis factor alpha and interleukin 1 beta after 2 h of silymarin administration in carrageenan induced rat paw edema besides the significant decrease of total cholesterol, triglycerides, low density lipoprotein and significantly elevated high density lipoprotein after 2 weeks of silymarin administration. Conclusions: These outcomes delivered a new vision into the possible pharmacological mechanisms by which silymarin advances antipyretic, anti-inflammatory, antinociceptive and antihyperlipidemic effects. |
format |
Article in Journal/Newspaper |
author |
Mohamed Mahmoud Amin Mahmoud Soliman Arbid |
author_facet |
Mohamed Mahmoud Amin Mahmoud Soliman Arbid |
author_sort |
Mohamed Mahmoud Amin |
title |
Estimation of the novel antipyretic, anti-inflammatory, antinociceptive and antihyperlipidemic effects of silymarin in Albino rats and mice |
title_short |
Estimation of the novel antipyretic, anti-inflammatory, antinociceptive and antihyperlipidemic effects of silymarin in Albino rats and mice |
title_full |
Estimation of the novel antipyretic, anti-inflammatory, antinociceptive and antihyperlipidemic effects of silymarin in Albino rats and mice |
title_fullStr |
Estimation of the novel antipyretic, anti-inflammatory, antinociceptive and antihyperlipidemic effects of silymarin in Albino rats and mice |
title_full_unstemmed |
Estimation of the novel antipyretic, anti-inflammatory, antinociceptive and antihyperlipidemic effects of silymarin in Albino rats and mice |
title_sort |
estimation of the novel antipyretic, anti-inflammatory, antinociceptive and antihyperlipidemic effects of silymarin in albino rats and mice |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2015 |
url |
https://doi.org/10.1016/j.apjtb.2015.05.009 https://doaj.org/article/a0a59fe03a064d5980885be06fa60758 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 8, Pp 619-623 (2015) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115001070 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.05.009 https://doaj.org/article/a0a59fe03a064d5980885be06fa60758 |
op_doi |
https://doi.org/10.1016/j.apjtb.2015.05.009 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
5 |
container_issue |
8 |
container_start_page |
619 |
op_container_end_page |
623 |
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1766343884691996672 |