EXPERIMENTAL PARACOCCIDIOIDOMYCOSIS IN PREGNANT RATS

• Published in: Revista do Instituto de Medicina Tropical de São Paulo
• Main Authors: Eduardo Alexandre LOTH, Vanessa CECATTO, Samia Khalil BIAZIM, José Henrique Fermino FERREIRA, Caroline DANIELLI, Rodrigo Daniel GENSKE, Rinaldo Ferreira GANDRA, Marcello Fabiano de FRANCO
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 2015
• Subjects: Paracoccidioidomycosis; Pregnant; Paracoccidioides brasiliensis; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic
• Online Access: https://doi.org/10.1590/S0036-46652015000600010; https://doaj.org/article/a07b3a09caf945a9b2c76cbf1526f701

Paracoccidioidomycosis (PCM), caused by the dimorphic fungus Paracoccidioides brasiliensis (Pb), is the most prevalent systemic mycosis in Latin America. There are few reports in the literature about the disease damages during pregnancy and the consequences to the fetuses and breeding. This study evaluated the implications of PCM during pregnancy on offspring and mothers in Wistar rats. Groups of rats were submitted to systemic Pb infection, by intraperitoneal infusion, and mated 30 days after the infection date. Immediately after birth, rats and neonates were sacrificed to obtain organs for standard histological examination, morphometric analysis, fungi recovery by plating (CFU) and dosing of anti-Pb antibodies by ELISA. There were no stillbirths or miscarriages, however, the fetuses from infected pregnant rats had lower body and organ weight but the fertility rate was 100%. The largest number of CFU was recovered from the organ of pregnant rats, the pathological examination revealed more severe infection in the same group, further on the largest number of granulomas and fungal field. It can be concluded that the PCM was more severe in the group of pregnant rats, with implications to the weight of offspring.