C-phycocyanin shows neuroprotective effect against rotenone-induced Parkinson’s disease in mice
Objective: To investigate the neuroprotective effect of C-phycocyanin in a mouse model of rotenone-induced Parkinson’s disease. Methods: C-phycocyanin (50 mg/kg, i.p., daily) was administered to rotenone (30 mg/kg, p.o., daily) treated mice for 28 days. Behavioral studies (Y-maze, rotarod, round bea...
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Wolters Kluwer Medknow Publications
2024
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ftdoajarticles:oai:doaj.org/article:9f896029fbee4deaae409d505087f4aa 2024-09-09T19:25:59+00:00 C-phycocyanin shows neuroprotective effect against rotenone-induced Parkinson’s disease in mice Hritik Rathod Ritu M. Soni Jigna S. Shah 2024-07-01T00:00:00Z https://doi.org/10.4103/apjtb.apjtb_229_24 https://doaj.org/article/9f896029fbee4deaae409d505087f4aa EN eng Wolters Kluwer Medknow Publications https://journals.lww.com/10.4103/apjtb.apjtb_229_24 https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/apjtb.apjtb_229_24 https://doaj.org/article/9f896029fbee4deaae409d505087f4aa Asian Pacific Journal of Tropical Biomedicine, Vol 14, Iss 7, Pp 279-287 (2024) parkinson’s disease c-phycocyanin alpha-synuclein bdnf oxidative stress rotenone Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2024 ftdoajarticles https://doi.org/10.4103/apjtb.apjtb_229_24 2024-08-05T17:48:40Z Objective: To investigate the neuroprotective effect of C-phycocyanin in a mouse model of rotenone-induced Parkinson’s disease. Methods: C-phycocyanin (50 mg/kg, i.p., daily) was administered to rotenone (30 mg/kg, p.o., daily) treated mice for 28 days. Behavioral studies (Y-maze, rotarod, round beam walk, and wire-hang tests) were carried out to assess neurobehavioral deficits. Glutathione and malondialdehyde were determined in both serum and striatal tissue. Molecular proteins (AKT, AMPK, NF-κB, BDNF, and alpha-synuclein) in the striatum were estimated using ELISA. Histopathological analyses (hematoxylin and eosin stainning as well as Nissl staining) were carried out to assess structural abnormalities in the striatum. Results: C-phycocyanin significantly increased BDNF levels and decreased alpha-synuclein levels. It also slightly upregulated AMPK and AKT levels without significant difference compared with the rotenone group. Additionally, rotenone-induced elevated oxidative stress and structural abnormalities in the striatum were markedly mitigated by C-phycocyanin. Conclusions: C-phycocyanin might have potential neuroprotective effects against Parkinson’s disease. Further studies are warranted to verify its efficacy and to understand the molecular mechanisms behind the neuroprotective effects of C-phycocyanin in Parkinson’s disease. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 14 7 279 287 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
parkinson’s disease c-phycocyanin alpha-synuclein bdnf oxidative stress rotenone Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
parkinson’s disease c-phycocyanin alpha-synuclein bdnf oxidative stress rotenone Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Hritik Rathod Ritu M. Soni Jigna S. Shah C-phycocyanin shows neuroprotective effect against rotenone-induced Parkinson’s disease in mice |
topic_facet |
parkinson’s disease c-phycocyanin alpha-synuclein bdnf oxidative stress rotenone Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To investigate the neuroprotective effect of C-phycocyanin in a mouse model of rotenone-induced Parkinson’s disease. Methods: C-phycocyanin (50 mg/kg, i.p., daily) was administered to rotenone (30 mg/kg, p.o., daily) treated mice for 28 days. Behavioral studies (Y-maze, rotarod, round beam walk, and wire-hang tests) were carried out to assess neurobehavioral deficits. Glutathione and malondialdehyde were determined in both serum and striatal tissue. Molecular proteins (AKT, AMPK, NF-κB, BDNF, and alpha-synuclein) in the striatum were estimated using ELISA. Histopathological analyses (hematoxylin and eosin stainning as well as Nissl staining) were carried out to assess structural abnormalities in the striatum. Results: C-phycocyanin significantly increased BDNF levels and decreased alpha-synuclein levels. It also slightly upregulated AMPK and AKT levels without significant difference compared with the rotenone group. Additionally, rotenone-induced elevated oxidative stress and structural abnormalities in the striatum were markedly mitigated by C-phycocyanin. Conclusions: C-phycocyanin might have potential neuroprotective effects against Parkinson’s disease. Further studies are warranted to verify its efficacy and to understand the molecular mechanisms behind the neuroprotective effects of C-phycocyanin in Parkinson’s disease. |
format |
Article in Journal/Newspaper |
author |
Hritik Rathod Ritu M. Soni Jigna S. Shah |
author_facet |
Hritik Rathod Ritu M. Soni Jigna S. Shah |
author_sort |
Hritik Rathod |
title |
C-phycocyanin shows neuroprotective effect against rotenone-induced Parkinson’s disease in mice |
title_short |
C-phycocyanin shows neuroprotective effect against rotenone-induced Parkinson’s disease in mice |
title_full |
C-phycocyanin shows neuroprotective effect against rotenone-induced Parkinson’s disease in mice |
title_fullStr |
C-phycocyanin shows neuroprotective effect against rotenone-induced Parkinson’s disease in mice |
title_full_unstemmed |
C-phycocyanin shows neuroprotective effect against rotenone-induced Parkinson’s disease in mice |
title_sort |
c-phycocyanin shows neuroprotective effect against rotenone-induced parkinson’s disease in mice |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2024 |
url |
https://doi.org/10.4103/apjtb.apjtb_229_24 https://doaj.org/article/9f896029fbee4deaae409d505087f4aa |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 14, Iss 7, Pp 279-287 (2024) |
op_relation |
https://journals.lww.com/10.4103/apjtb.apjtb_229_24 https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/apjtb.apjtb_229_24 https://doaj.org/article/9f896029fbee4deaae409d505087f4aa |
op_doi |
https://doi.org/10.4103/apjtb.apjtb_229_24 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
14 |
container_issue |
7 |
container_start_page |
279 |
op_container_end_page |
287 |
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1809895698727960576 |