Artenimol–piperaquine in children with uncomplicated imported falciparum malaria: experience from a prospective cohort
Abstract Background Although malaria remains one of the major public health threats in inter-tropical areas, there is limited understanding of imported malaria in children by paediatricians and emergency practitioners in non-endemic countries, often resulting in misdiagnosis and inadequate treatment...
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ftdoajarticles:oai:doaj.org/article:9f698af694e140f58bfe44e5e9d133dc 2023-05-15T15:12:45+02:00 Artenimol–piperaquine in children with uncomplicated imported falciparum malaria: experience from a prospective cohort Lauren Pull Jean-Marc Lupoglazoff Matthew Beardmore Jean-François Michel Pierre Buffet Olivier Bouchaud Jean-Yves Siriez 2019-12-01T00:00:00Z https://doi.org/10.1186/s12936-019-3047-9 https://doaj.org/article/9f698af694e140f58bfe44e5e9d133dc EN eng BMC https://doi.org/10.1186/s12936-019-3047-9 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-3047-9 1475-2875 https://doaj.org/article/9f698af694e140f58bfe44e5e9d133dc Malaria Journal, Vol 18, Iss 1, Pp 1-5 (2019) Imported malaria Children Artenimol–piperaquine QTc interval Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2019 ftdoajarticles https://doi.org/10.1186/s12936-019-3047-9 2022-12-31T12:24:38Z Abstract Background Although malaria remains one of the major public health threats in inter-tropical areas, there is limited understanding of imported malaria in children by paediatricians and emergency practitioners in non-endemic countries, often resulting in misdiagnosis and inadequate treatment. Moreover, classical treatments (atovaquone-proguanil, quinine, mefloquine) are limited either by lengthy treatment courses or by side effects. Since 2010, the World Health Organization (WHO) has recommended the use of oral artemisinin-based combination therapy for the treatment of uncomplicated Plasmodium falciparum malaria worldwide. The benefits of artenimol–piperaquine in children have been validated in endemic countries but experience remains limited in cases of imported malaria. Methods This prospective observational study in routine paediatric care took place at the Emergency Department, Robert-Debré Hospital (Paris, France) from September 2012 to December 2014. Tolerance and efficacy of artenimol–piperaquine in children presenting with the following inclusion criteria were assessed: P. falciparum positive on thin or thick blood smear; and the absence of WHO-defined features of severity. Results Among 83 children included in this study, treatment with artenimol–piperaquine was successful in 82 children (98.8%). None of the adverse events were severe and all were considered mild with no significant clinical impact. This also applied to cardiological adverse events despite a significant increase of the mean post-treatment QTc interval. Conclusion Artenimol–piperaquine displays a satisfying efficacy and tolerance profile as a first-line treatment for children with imported uncomplicated falciparum malaria and only necessitates three once-daily oral intakes of the medication. Comparative studies versus artemether-lumefantrine or atovaquone-proguanil would be useful to confirm the results of this study. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 18 1 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Imported malaria Children Artenimol–piperaquine QTc interval Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Imported malaria Children Artenimol–piperaquine QTc interval Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Lauren Pull Jean-Marc Lupoglazoff Matthew Beardmore Jean-François Michel Pierre Buffet Olivier Bouchaud Jean-Yves Siriez Artenimol–piperaquine in children with uncomplicated imported falciparum malaria: experience from a prospective cohort |
topic_facet |
Imported malaria Children Artenimol–piperaquine QTc interval Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Although malaria remains one of the major public health threats in inter-tropical areas, there is limited understanding of imported malaria in children by paediatricians and emergency practitioners in non-endemic countries, often resulting in misdiagnosis and inadequate treatment. Moreover, classical treatments (atovaquone-proguanil, quinine, mefloquine) are limited either by lengthy treatment courses or by side effects. Since 2010, the World Health Organization (WHO) has recommended the use of oral artemisinin-based combination therapy for the treatment of uncomplicated Plasmodium falciparum malaria worldwide. The benefits of artenimol–piperaquine in children have been validated in endemic countries but experience remains limited in cases of imported malaria. Methods This prospective observational study in routine paediatric care took place at the Emergency Department, Robert-Debré Hospital (Paris, France) from September 2012 to December 2014. Tolerance and efficacy of artenimol–piperaquine in children presenting with the following inclusion criteria were assessed: P. falciparum positive on thin or thick blood smear; and the absence of WHO-defined features of severity. Results Among 83 children included in this study, treatment with artenimol–piperaquine was successful in 82 children (98.8%). None of the adverse events were severe and all were considered mild with no significant clinical impact. This also applied to cardiological adverse events despite a significant increase of the mean post-treatment QTc interval. Conclusion Artenimol–piperaquine displays a satisfying efficacy and tolerance profile as a first-line treatment for children with imported uncomplicated falciparum malaria and only necessitates three once-daily oral intakes of the medication. Comparative studies versus artemether-lumefantrine or atovaquone-proguanil would be useful to confirm the results of this study. |
format |
Article in Journal/Newspaper |
author |
Lauren Pull Jean-Marc Lupoglazoff Matthew Beardmore Jean-François Michel Pierre Buffet Olivier Bouchaud Jean-Yves Siriez |
author_facet |
Lauren Pull Jean-Marc Lupoglazoff Matthew Beardmore Jean-François Michel Pierre Buffet Olivier Bouchaud Jean-Yves Siriez |
author_sort |
Lauren Pull |
title |
Artenimol–piperaquine in children with uncomplicated imported falciparum malaria: experience from a prospective cohort |
title_short |
Artenimol–piperaquine in children with uncomplicated imported falciparum malaria: experience from a prospective cohort |
title_full |
Artenimol–piperaquine in children with uncomplicated imported falciparum malaria: experience from a prospective cohort |
title_fullStr |
Artenimol–piperaquine in children with uncomplicated imported falciparum malaria: experience from a prospective cohort |
title_full_unstemmed |
Artenimol–piperaquine in children with uncomplicated imported falciparum malaria: experience from a prospective cohort |
title_sort |
artenimol–piperaquine in children with uncomplicated imported falciparum malaria: experience from a prospective cohort |
publisher |
BMC |
publishDate |
2019 |
url |
https://doi.org/10.1186/s12936-019-3047-9 https://doaj.org/article/9f698af694e140f58bfe44e5e9d133dc |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 18, Iss 1, Pp 1-5 (2019) |
op_relation |
https://doi.org/10.1186/s12936-019-3047-9 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-3047-9 1475-2875 https://doaj.org/article/9f698af694e140f58bfe44e5e9d133dc |
op_doi |
https://doi.org/10.1186/s12936-019-3047-9 |
container_title |
Malaria Journal |
container_volume |
18 |
container_issue |
1 |
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1766343388153511936 |