Cross-neutralization of the coagulant activity of Crotalus durissus terrificus venom from the northeast of Argentina by bivalent bothropic antivenom
Cross-neutralization of Crotalus durissus terrificus venom coagulant activity was tested using bivalent horse antivenom against Bothrops alternatus and Bothrops diporus venoms. Our in vitro and in vivo experiments showed that bothropic antivenom neutralizes the thrombin-like activity of crotalic sna...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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Language: | English |
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2012
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Online Access: | https://doi.org/10.1590/S1678-91992012000100015 https://doaj.org/article/9eb652599e2d4751b556a531cd8ea66e |
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ftdoajarticles:oai:doaj.org/article:9eb652599e2d4751b556a531cd8ea66e 2023-05-15T15:01:05+02:00 Cross-neutralization of the coagulant activity of Crotalus durissus terrificus venom from the northeast of Argentina by bivalent bothropic antivenom JP Rodríguez CC Gay LS Fusco MC Gauna OC Acosta LC Leiva 2012-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992012000100015 https://doaj.org/article/9eb652599e2d4751b556a531cd8ea66e EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000100015 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992012000100015 1678-9199 https://doaj.org/article/9eb652599e2d4751b556a531cd8ea66e Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 18, Iss 1, Pp 116-123 (2012) thrombin-like enzyme snake venom antivenoms immunological cross-reaction Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2012 ftdoajarticles https://doi.org/10.1590/S1678-91992012000100015 2022-12-31T00:58:04Z Cross-neutralization of Crotalus durissus terrificus venom coagulant activity was tested using bivalent horse antivenom against Bothrops alternatus and Bothrops diporus venoms. Our in vitro and in vivo experiments showed that bothropic antivenom neutralizes the thrombin-like activity of crotalic snake venom and this cross-reaction was demonstrated by immunoassays either with whole venom or a purified thrombin-like enzyme. These results suggest common antigenic properties and, consequently, similar molecular structure among venom thrombin-like enzymes. Besides, they provide information that could be further used in the development of new antivenom formulations. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Argentina Journal of Venomous Animals and Toxins including Tropical Diseases 18 1 116 123 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
thrombin-like enzyme snake venom antivenoms immunological cross-reaction Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
thrombin-like enzyme snake venom antivenoms immunological cross-reaction Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 JP Rodríguez CC Gay LS Fusco MC Gauna OC Acosta LC Leiva Cross-neutralization of the coagulant activity of Crotalus durissus terrificus venom from the northeast of Argentina by bivalent bothropic antivenom |
topic_facet |
thrombin-like enzyme snake venom antivenoms immunological cross-reaction Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Cross-neutralization of Crotalus durissus terrificus venom coagulant activity was tested using bivalent horse antivenom against Bothrops alternatus and Bothrops diporus venoms. Our in vitro and in vivo experiments showed that bothropic antivenom neutralizes the thrombin-like activity of crotalic snake venom and this cross-reaction was demonstrated by immunoassays either with whole venom or a purified thrombin-like enzyme. These results suggest common antigenic properties and, consequently, similar molecular structure among venom thrombin-like enzymes. Besides, they provide information that could be further used in the development of new antivenom formulations. |
format |
Article in Journal/Newspaper |
author |
JP Rodríguez CC Gay LS Fusco MC Gauna OC Acosta LC Leiva |
author_facet |
JP Rodríguez CC Gay LS Fusco MC Gauna OC Acosta LC Leiva |
author_sort |
JP Rodríguez |
title |
Cross-neutralization of the coagulant activity of Crotalus durissus terrificus venom from the northeast of Argentina by bivalent bothropic antivenom |
title_short |
Cross-neutralization of the coagulant activity of Crotalus durissus terrificus venom from the northeast of Argentina by bivalent bothropic antivenom |
title_full |
Cross-neutralization of the coagulant activity of Crotalus durissus terrificus venom from the northeast of Argentina by bivalent bothropic antivenom |
title_fullStr |
Cross-neutralization of the coagulant activity of Crotalus durissus terrificus venom from the northeast of Argentina by bivalent bothropic antivenom |
title_full_unstemmed |
Cross-neutralization of the coagulant activity of Crotalus durissus terrificus venom from the northeast of Argentina by bivalent bothropic antivenom |
title_sort |
cross-neutralization of the coagulant activity of crotalus durissus terrificus venom from the northeast of argentina by bivalent bothropic antivenom |
publisher |
SciELO |
publishDate |
2012 |
url |
https://doi.org/10.1590/S1678-91992012000100015 https://doaj.org/article/9eb652599e2d4751b556a531cd8ea66e |
geographic |
Arctic Argentina |
geographic_facet |
Arctic Argentina |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 18, Iss 1, Pp 116-123 (2012) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000100015 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992012000100015 1678-9199 https://doaj.org/article/9eb652599e2d4751b556a531cd8ea66e |
op_doi |
https://doi.org/10.1590/S1678-91992012000100015 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
18 |
container_issue |
1 |
container_start_page |
116 |
op_container_end_page |
123 |
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1766333123528753152 |