Immunomodulatory and anticancer activity of Bombax ceiba Linn leaf extract
Objective: To evaluate the immunomodulatory and anticancer activity of the methanolic extract of Bombax ceiba leaves in vitro and in vivo. Methods: The antioxidant property of methanolic extract of Bombax ceiba leaves was determined by measuring hydrogen peroxide scavenging and DPPH scavenging activ...
Published in: | Asian Pacific Journal of Tropical Biomedicine |
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Wolters Kluwer Medknow Publications
2020
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ftdoajarticles:oai:doaj.org/article:9ea9387d091f4315a309e91fac78229b 2023-05-15T15:06:40+02:00 Immunomodulatory and anticancer activity of Bombax ceiba Linn leaf extract Neelima Sharma Sneha Kispotta Papiya Mitra Mazumder 2020-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.290134 https://doaj.org/article/9ea9387d091f4315a309e91fac78229b EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2020;volume=10;issue=9;spage=426;epage=432;aulast=Sharma https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.290134 https://doaj.org/article/9ea9387d091f4315a309e91fac78229b Asian Pacific Journal of Tropical Biomedicine, Vol 10, Iss 9, Pp 426-432 (2020) anticancer antioxidative bombax ceiba immunomodulatory Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2020 ftdoajarticles https://doi.org/10.4103/2221-1691.290134 2023-01-08T01:29:22Z Objective: To evaluate the immunomodulatory and anticancer activity of the methanolic extract of Bombax ceiba leaves in vitro and in vivo. Methods: The antioxidant property of methanolic extract of Bombax ceiba leaves was determined by measuring hydrogen peroxide scavenging and DPPH scavenging activity. The effect on cellular immunity in vivo was determined by measuring neutrophil adhesion, carbon clearance, sheep red blood cell induced DTH response and cyclophosphamide-induced myelosuppression. In vitro anticancer activity was evaluated on human leukaemia cell line (HL-60) by MTT assay, caspase-3 activity, and cell cycle study. Results: The methanolic extract of Bombax ceiba leaves showed antioxidant activity and significantly increased neutrophil adhesion, carbon clearance from blood, DTH response and cyclophosphamide-induced myelosuppression. The MTT assay showed a significant increase in the death of HL-60 cell line. A rise in caspase-3 activity and sub-G1 population in the presence of methanolic extract of Bombax ceiba leaves was observed. Conclusions: The methanolic extract of leaves of Bombax ceiba L possesses anticancer activity, immunomodulatory activity, and antioxidant properties, proving its therapeutic usefulness in the treatment of immuno-compromised diseases and cancers. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 10 9 426 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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language |
English |
topic |
anticancer antioxidative bombax ceiba immunomodulatory Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
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anticancer antioxidative bombax ceiba immunomodulatory Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Neelima Sharma Sneha Kispotta Papiya Mitra Mazumder Immunomodulatory and anticancer activity of Bombax ceiba Linn leaf extract |
topic_facet |
anticancer antioxidative bombax ceiba immunomodulatory Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To evaluate the immunomodulatory and anticancer activity of the methanolic extract of Bombax ceiba leaves in vitro and in vivo. Methods: The antioxidant property of methanolic extract of Bombax ceiba leaves was determined by measuring hydrogen peroxide scavenging and DPPH scavenging activity. The effect on cellular immunity in vivo was determined by measuring neutrophil adhesion, carbon clearance, sheep red blood cell induced DTH response and cyclophosphamide-induced myelosuppression. In vitro anticancer activity was evaluated on human leukaemia cell line (HL-60) by MTT assay, caspase-3 activity, and cell cycle study. Results: The methanolic extract of Bombax ceiba leaves showed antioxidant activity and significantly increased neutrophil adhesion, carbon clearance from blood, DTH response and cyclophosphamide-induced myelosuppression. The MTT assay showed a significant increase in the death of HL-60 cell line. A rise in caspase-3 activity and sub-G1 population in the presence of methanolic extract of Bombax ceiba leaves was observed. Conclusions: The methanolic extract of leaves of Bombax ceiba L possesses anticancer activity, immunomodulatory activity, and antioxidant properties, proving its therapeutic usefulness in the treatment of immuno-compromised diseases and cancers. |
format |
Article in Journal/Newspaper |
author |
Neelima Sharma Sneha Kispotta Papiya Mitra Mazumder |
author_facet |
Neelima Sharma Sneha Kispotta Papiya Mitra Mazumder |
author_sort |
Neelima Sharma |
title |
Immunomodulatory and anticancer activity of Bombax ceiba Linn leaf extract |
title_short |
Immunomodulatory and anticancer activity of Bombax ceiba Linn leaf extract |
title_full |
Immunomodulatory and anticancer activity of Bombax ceiba Linn leaf extract |
title_fullStr |
Immunomodulatory and anticancer activity of Bombax ceiba Linn leaf extract |
title_full_unstemmed |
Immunomodulatory and anticancer activity of Bombax ceiba Linn leaf extract |
title_sort |
immunomodulatory and anticancer activity of bombax ceiba linn leaf extract |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2020 |
url |
https://doi.org/10.4103/2221-1691.290134 https://doaj.org/article/9ea9387d091f4315a309e91fac78229b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 10, Iss 9, Pp 426-432 (2020) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2020;volume=10;issue=9;spage=426;epage=432;aulast=Sharma https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.290134 https://doaj.org/article/9ea9387d091f4315a309e91fac78229b |
op_doi |
https://doi.org/10.4103/2221-1691.290134 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
10 |
container_issue |
9 |
container_start_page |
426 |
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1766338229408104448 |