First Identification and Description of Rickettsioses and Q Fever as Causes of Acute Febrile Illness in Nicaragua.
BACKGROUND:Rickettsial infections and Q fever present similarly to other acute febrile illnesses, but are infrequently diagnosed because of limited diagnostic tools. Despite sporadic reports, rickettsial infections and Q fever have not been prospectively studied in Central America. METHODOLOGY/PRINC...
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ftdoajarticles:oai:doaj.org/article:9e531f3ad6234928b9ed558529e70f04 2023-05-15T15:04:33+02:00 First Identification and Description of Rickettsioses and Q Fever as Causes of Acute Febrile Illness in Nicaragua. Megan E Reller Ijeuru Chikeka Jeremy J Miles J Stephen Dumler Christopher W Woods Orlando Mayorga Armando J Matute 2016-12-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005185 https://doaj.org/article/9e531f3ad6234928b9ed558529e70f04 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5201229?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005185 https://doaj.org/article/9e531f3ad6234928b9ed558529e70f04 PLoS Neglected Tropical Diseases, Vol 10, Iss 12, p e0005185 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005185 2022-12-30T21:04:27Z BACKGROUND:Rickettsial infections and Q fever present similarly to other acute febrile illnesses, but are infrequently diagnosed because of limited diagnostic tools. Despite sporadic reports, rickettsial infections and Q fever have not been prospectively studied in Central America. METHODOLOGY/PRINCIPAL FINDINGS:We enrolled consecutive patients presenting with undifferentiated fever in western Nicaragua and collected epidemiologic and clinical data and acute and convalescent sera. We used ELISA for screening and paired sera to confirm acute (≥4-fold rise in titer) spotted fever and typhus group rickettsial infections and Q fever as well as past (stable titer) infections. Characteristics associated with both acute and past infection were assessed. CONCLUSIONS/SIGNIFICANCE:We enrolled 825 patients and identified acute rickettsial infections and acute Q fever in 0.9% and 1.3%, respectively. Clinical features were non-specific and neither rickettsial infections nor Q fever were considered or treated. Further study is warranted to define the burden of these infections in Central America. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 12 e0005185 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Megan E Reller Ijeuru Chikeka Jeremy J Miles J Stephen Dumler Christopher W Woods Orlando Mayorga Armando J Matute First Identification and Description of Rickettsioses and Q Fever as Causes of Acute Febrile Illness in Nicaragua. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Rickettsial infections and Q fever present similarly to other acute febrile illnesses, but are infrequently diagnosed because of limited diagnostic tools. Despite sporadic reports, rickettsial infections and Q fever have not been prospectively studied in Central America. METHODOLOGY/PRINCIPAL FINDINGS:We enrolled consecutive patients presenting with undifferentiated fever in western Nicaragua and collected epidemiologic and clinical data and acute and convalescent sera. We used ELISA for screening and paired sera to confirm acute (≥4-fold rise in titer) spotted fever and typhus group rickettsial infections and Q fever as well as past (stable titer) infections. Characteristics associated with both acute and past infection were assessed. CONCLUSIONS/SIGNIFICANCE:We enrolled 825 patients and identified acute rickettsial infections and acute Q fever in 0.9% and 1.3%, respectively. Clinical features were non-specific and neither rickettsial infections nor Q fever were considered or treated. Further study is warranted to define the burden of these infections in Central America. |
format |
Article in Journal/Newspaper |
author |
Megan E Reller Ijeuru Chikeka Jeremy J Miles J Stephen Dumler Christopher W Woods Orlando Mayorga Armando J Matute |
author_facet |
Megan E Reller Ijeuru Chikeka Jeremy J Miles J Stephen Dumler Christopher W Woods Orlando Mayorga Armando J Matute |
author_sort |
Megan E Reller |
title |
First Identification and Description of Rickettsioses and Q Fever as Causes of Acute Febrile Illness in Nicaragua. |
title_short |
First Identification and Description of Rickettsioses and Q Fever as Causes of Acute Febrile Illness in Nicaragua. |
title_full |
First Identification and Description of Rickettsioses and Q Fever as Causes of Acute Febrile Illness in Nicaragua. |
title_fullStr |
First Identification and Description of Rickettsioses and Q Fever as Causes of Acute Febrile Illness in Nicaragua. |
title_full_unstemmed |
First Identification and Description of Rickettsioses and Q Fever as Causes of Acute Febrile Illness in Nicaragua. |
title_sort |
first identification and description of rickettsioses and q fever as causes of acute febrile illness in nicaragua. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0005185 https://doaj.org/article/9e531f3ad6234928b9ed558529e70f04 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 12, p e0005185 (2016) |
op_relation |
http://europepmc.org/articles/PMC5201229?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005185 https://doaj.org/article/9e531f3ad6234928b9ed558529e70f04 |
op_doi |
https://doi.org/10.1371/journal.pntd.0005185 |
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PLOS Neglected Tropical Diseases |
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10 |
container_issue |
12 |
container_start_page |
e0005185 |
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1766336299603591168 |