Biofilm-forming fluconazole-resistant Candida auris causing vulvovaginal candidiasis in an immunocompetent patient: A case report
Rationale: Candida auris is a potential emerging pathogen among Candida and causes serious health threats globally. Patient concerns: We reported a case of vulvovaginal candidiasis caused by Candida auris. A 26-year-old female presented with complaints of vaginal discharge, itching and low back pain...
Published in: | Asian Pacific Journal of Tropical Medicine |
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:9dd370a8084f4893b19ad7f2921cd86b 2023-05-15T15:06:29+02:00 Biofilm-forming fluconazole-resistant Candida auris causing vulvovaginal candidiasis in an immunocompetent patient: A case report Lakshmi Krishnasamy Jayasankari Senthilganesh Chitralekha Saikumar Paramasivam Nithyanand 2021-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.306768 https://doaj.org/article/9dd370a8084f4893b19ad7f2921cd86b EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2021;volume=14;issue=2;spage=94;epage=96;aulast=Krishnasamy https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.306768 https://doaj.org/article/9dd370a8084f4893b19ad7f2921cd86b Asian Pacific Journal of Tropical Medicine, Vol 14, Iss 2, Pp 94-96 (2021) candida auris resistance biofilm scanning electron microscopy Arctic medicine. Tropical medicine RC955-962 article 2021 ftdoajarticles https://doi.org/10.4103/1995-7645.306768 2022-12-31T00:28:49Z Rationale: Candida auris is a potential emerging pathogen among Candida and causes serious health threats globally. Patient concerns: We reported a case of vulvovaginal candidiasis caused by Candida auris. A 26-year-old female presented with complaints of vaginal discharge, itching and low back pain. Diagnosis: High vaginal swab culture yielded Candida. The strain was confirmed as Candida auris by amplification and sequencing the internal transcribed spacer region. Antifungal susceptibility testing revealed that the isolate was resistant to fluconazole, amphotericin B and clotrimazole and susceptible to ketoconazole and nystatin. The isolate also exhibited biofilm forming ability. Interventions: Her symptoms did not subside with initial management with fluconazole and clotrimazole. Later, she was started on ketoconazole therapy. The patient responded well to ketoconazole. Outcome and lessons: To the best of our knowledge, this is the first report about the presence of a drug resistant biofilm forming Candida auris strain isolated from a vaginal swab sample from Chennai area. Biofilm forming ability might contribute to its drug resistance. Nucleic acid analysis helps in rapid and accurate identification of such rare species. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 14 2 94 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
candida auris resistance biofilm scanning electron microscopy Arctic medicine. Tropical medicine RC955-962 |
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candida auris resistance biofilm scanning electron microscopy Arctic medicine. Tropical medicine RC955-962 Lakshmi Krishnasamy Jayasankari Senthilganesh Chitralekha Saikumar Paramasivam Nithyanand Biofilm-forming fluconazole-resistant Candida auris causing vulvovaginal candidiasis in an immunocompetent patient: A case report |
topic_facet |
candida auris resistance biofilm scanning electron microscopy Arctic medicine. Tropical medicine RC955-962 |
description |
Rationale: Candida auris is a potential emerging pathogen among Candida and causes serious health threats globally. Patient concerns: We reported a case of vulvovaginal candidiasis caused by Candida auris. A 26-year-old female presented with complaints of vaginal discharge, itching and low back pain. Diagnosis: High vaginal swab culture yielded Candida. The strain was confirmed as Candida auris by amplification and sequencing the internal transcribed spacer region. Antifungal susceptibility testing revealed that the isolate was resistant to fluconazole, amphotericin B and clotrimazole and susceptible to ketoconazole and nystatin. The isolate also exhibited biofilm forming ability. Interventions: Her symptoms did not subside with initial management with fluconazole and clotrimazole. Later, she was started on ketoconazole therapy. The patient responded well to ketoconazole. Outcome and lessons: To the best of our knowledge, this is the first report about the presence of a drug resistant biofilm forming Candida auris strain isolated from a vaginal swab sample from Chennai area. Biofilm forming ability might contribute to its drug resistance. Nucleic acid analysis helps in rapid and accurate identification of such rare species. |
format |
Article in Journal/Newspaper |
author |
Lakshmi Krishnasamy Jayasankari Senthilganesh Chitralekha Saikumar Paramasivam Nithyanand |
author_facet |
Lakshmi Krishnasamy Jayasankari Senthilganesh Chitralekha Saikumar Paramasivam Nithyanand |
author_sort |
Lakshmi Krishnasamy |
title |
Biofilm-forming fluconazole-resistant Candida auris causing vulvovaginal candidiasis in an immunocompetent patient: A case report |
title_short |
Biofilm-forming fluconazole-resistant Candida auris causing vulvovaginal candidiasis in an immunocompetent patient: A case report |
title_full |
Biofilm-forming fluconazole-resistant Candida auris causing vulvovaginal candidiasis in an immunocompetent patient: A case report |
title_fullStr |
Biofilm-forming fluconazole-resistant Candida auris causing vulvovaginal candidiasis in an immunocompetent patient: A case report |
title_full_unstemmed |
Biofilm-forming fluconazole-resistant Candida auris causing vulvovaginal candidiasis in an immunocompetent patient: A case report |
title_sort |
biofilm-forming fluconazole-resistant candida auris causing vulvovaginal candidiasis in an immunocompetent patient: a case report |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2021 |
url |
https://doi.org/10.4103/1995-7645.306768 https://doaj.org/article/9dd370a8084f4893b19ad7f2921cd86b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 14, Iss 2, Pp 94-96 (2021) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2021;volume=14;issue=2;spage=94;epage=96;aulast=Krishnasamy https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.306768 https://doaj.org/article/9dd370a8084f4893b19ad7f2921cd86b |
op_doi |
https://doi.org/10.4103/1995-7645.306768 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
14 |
container_issue |
2 |
container_start_page |
94 |
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