In vitro susceptibility to antifungal agents of clinical and environmental Cryptococcus neoformans isolated in Southern of Brazil

• Main Authors: Sydney Hartz ALVES, Loiva T. OLIVEIRA, Jane M. COSTA, Irina LUBECK, Agnes Kiesling CASALI, Marilene Henning VAINSTEIN
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 2001
• Subjects: Cryptococcus neoformans; Susceptibility; Antifungal agents; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic
• Online Access: https://doaj.org/article/9da4338b940a498bb6f232aeeb9b5e1c

The purpose of the present study was to compare the susceptibility to four antifungal agents of 69 Cryptococcus neoformans strains isolated from AIDS patients with that of 13 C. neoformans strains isolated from the environment. Based on the NCCLS M27-A methodology the Minimal Inhibitory Concentrations (MICs) obtained for amphotericin B, itraconazole and ketoconazole were very similar for clinical and environmental isolates. Clinical isolates were less susceptible to fluconazole than environmental isolates. The significance of these findings and aspects concerning the importance, role and difficulties of C. neoformans susceptibility testing are also discussed.