The association of parasitic infections in pregnancy and maternal and fetal anemia: a cohort study in coastal Kenya.
Background Relative contribution of these infections on anemia in pregnancy is not certain. While measures to protect pregnant women against malaria have been scaling up, interventions against helminthes have received much less attention. In this study, we determine the relative impact of helminthes...
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ftdoajarticles:oai:doaj.org/article:9d414fac0fd64c989519fab46d2c66d3 2023-05-15T15:15:46+02:00 The association of parasitic infections in pregnancy and maternal and fetal anemia: a cohort study in coastal Kenya. Elizabeth M McClure Steven R Meshnick Peter Mungai Indu Malhotra Christopher L King Robert L Goldenberg Michael G Hudgens Anna Maria Siega-Riz Arlene E Dent 2014-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002724 https://doaj.org/article/9d414fac0fd64c989519fab46d2c66d3 EN eng Public Library of Science (PLoS) https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24587473/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002724 https://doaj.org/article/9d414fac0fd64c989519fab46d2c66d3 PLoS Neglected Tropical Diseases, Vol 8, Iss 2, p e2724 (2014) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2014 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002724 2022-12-31T16:34:46Z Background Relative contribution of these infections on anemia in pregnancy is not certain. While measures to protect pregnant women against malaria have been scaling up, interventions against helminthes have received much less attention. In this study, we determine the relative impact of helminthes and malaria on maternal anemia. Methods A prospective observational study was conducted in coastal Kenya among a cohort of pregnant women who were recruited at their first antenatal care (ANC) visit and tested for malaria, hookworm, and other parasitic infections and anemia at enrollment. All women enrolled in the study received presumptive treatment with sulfadoxine-pyrimethamine, iron and multi-vitamins and women diagnosed with helminthic infections were treated with albendazole. Women delivering a live, term birth, were also tested for maternal anemia, fetal anemia and presence of infection at delivery. Principal findings Of the 706 women studied, at the first ANC visit, 27% had moderate/severe anemia and 71% of women were anemic overall. The infections with highest prevalence were hookworm (24%), urogenital schistosomiasis (17%), trichuria (10%), and malaria (9%). In adjusted and unadjusted analyses, moderate/severe anemia at first ANC visit was associated with the higher intensities of hookworm and P. falciparum microscopy-malaria infections. At delivery, 34% of women had moderate/severe anemia and 18% of infants' cord hemoglobin was consistent with fetal anemia. While none of the maternal infections were significantly associated with fetal anemia, moderate/severe maternal anemia was associated with fetal anemia. Conclusions More than one quarter of women receiving standard ANC with IPTp for malaria had moderate/severe anemia in pregnancy and high rates of parasitic infection. Thus, addressing the role of co-infections, such as hookworm, as well as under-nutrition, and their contribution to anemia is needed. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 8 2 e2724 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Elizabeth M McClure Steven R Meshnick Peter Mungai Indu Malhotra Christopher L King Robert L Goldenberg Michael G Hudgens Anna Maria Siega-Riz Arlene E Dent The association of parasitic infections in pregnancy and maternal and fetal anemia: a cohort study in coastal Kenya. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Relative contribution of these infections on anemia in pregnancy is not certain. While measures to protect pregnant women against malaria have been scaling up, interventions against helminthes have received much less attention. In this study, we determine the relative impact of helminthes and malaria on maternal anemia. Methods A prospective observational study was conducted in coastal Kenya among a cohort of pregnant women who were recruited at their first antenatal care (ANC) visit and tested for malaria, hookworm, and other parasitic infections and anemia at enrollment. All women enrolled in the study received presumptive treatment with sulfadoxine-pyrimethamine, iron and multi-vitamins and women diagnosed with helminthic infections were treated with albendazole. Women delivering a live, term birth, were also tested for maternal anemia, fetal anemia and presence of infection at delivery. Principal findings Of the 706 women studied, at the first ANC visit, 27% had moderate/severe anemia and 71% of women were anemic overall. The infections with highest prevalence were hookworm (24%), urogenital schistosomiasis (17%), trichuria (10%), and malaria (9%). In adjusted and unadjusted analyses, moderate/severe anemia at first ANC visit was associated with the higher intensities of hookworm and P. falciparum microscopy-malaria infections. At delivery, 34% of women had moderate/severe anemia and 18% of infants' cord hemoglobin was consistent with fetal anemia. While none of the maternal infections were significantly associated with fetal anemia, moderate/severe maternal anemia was associated with fetal anemia. Conclusions More than one quarter of women receiving standard ANC with IPTp for malaria had moderate/severe anemia in pregnancy and high rates of parasitic infection. Thus, addressing the role of co-infections, such as hookworm, as well as under-nutrition, and their contribution to anemia is needed. |
format |
Article in Journal/Newspaper |
author |
Elizabeth M McClure Steven R Meshnick Peter Mungai Indu Malhotra Christopher L King Robert L Goldenberg Michael G Hudgens Anna Maria Siega-Riz Arlene E Dent |
author_facet |
Elizabeth M McClure Steven R Meshnick Peter Mungai Indu Malhotra Christopher L King Robert L Goldenberg Michael G Hudgens Anna Maria Siega-Riz Arlene E Dent |
author_sort |
Elizabeth M McClure |
title |
The association of parasitic infections in pregnancy and maternal and fetal anemia: a cohort study in coastal Kenya. |
title_short |
The association of parasitic infections in pregnancy and maternal and fetal anemia: a cohort study in coastal Kenya. |
title_full |
The association of parasitic infections in pregnancy and maternal and fetal anemia: a cohort study in coastal Kenya. |
title_fullStr |
The association of parasitic infections in pregnancy and maternal and fetal anemia: a cohort study in coastal Kenya. |
title_full_unstemmed |
The association of parasitic infections in pregnancy and maternal and fetal anemia: a cohort study in coastal Kenya. |
title_sort |
association of parasitic infections in pregnancy and maternal and fetal anemia: a cohort study in coastal kenya. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pntd.0002724 https://doaj.org/article/9d414fac0fd64c989519fab46d2c66d3 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 8, Iss 2, p e2724 (2014) |
op_relation |
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24587473/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002724 https://doaj.org/article/9d414fac0fd64c989519fab46d2c66d3 |
op_doi |
https://doi.org/10.1371/journal.pntd.0002724 |
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PLoS Neglected Tropical Diseases |
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8 |
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2 |
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e2724 |
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