The mitochondrial genome of Toxocara canis.
Toxocara canis (Ascaridida: Nematoda), which parasitizes (at the adult stage) the small intestine of canids, can be transmitted to a range of other mammals, including humans, and can cause the disease toxocariasis. Despite its significance as a pathogen, the genetics, epidemiology and biology of thi...
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ftdoajarticles:oai:doaj.org/article:9d3c0123b7104f82820a31b4f749f5a0 2023-05-15T15:07:14+02:00 The mitochondrial genome of Toxocara canis. Aaron R Jex Andrea Waeschenbach D Timothy J Littlewood Min Hu Robin B Gasser 2008-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000273 https://doaj.org/article/9d3c0123b7104f82820a31b4f749f5a0 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2483351?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000273 https://doaj.org/article/9d3c0123b7104f82820a31b4f749f5a0 PLoS Neglected Tropical Diseases, Vol 2, Iss 8, p e273 (2008) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2008 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000273 2022-12-31T11:41:19Z Toxocara canis (Ascaridida: Nematoda), which parasitizes (at the adult stage) the small intestine of canids, can be transmitted to a range of other mammals, including humans, and can cause the disease toxocariasis. Despite its significance as a pathogen, the genetics, epidemiology and biology of this parasite remain poorly understood. In addition, the zoonotic potential of related species of Toxocara, such as T. cati and T. malaysiensis, is not well known. Mitochondrial DNA is known to provide genetic markers for investigations in these areas, but complete mitochondrial genomic data have been lacking for T. canis and its congeners. In the present study, the mitochondrial genome of T. canis was amplified by long-range polymerase chain reaction (long PCR) and sequenced using a primer-walking strategy. This circular mitochondrial genome was 14162 bp and contained 12 protein-coding, 22 transfer RNA, and 2 ribosomal RNA genes consistent for secementean nematodes, including Ascaris suum and Anisakis simplex (Ascaridida). The mitochondrial genome of T. canis provides genetic markers for studies into the systematics, population genetics and epidemiology of this zoonotic parasite and its congeners. Such markers can now be used in prospecting for cryptic species and for exploring host specificity and zoonotic potential, thus underpinning the prevention and control of toxocariasis in humans and other hosts. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 2 8 e273 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Aaron R Jex Andrea Waeschenbach D Timothy J Littlewood Min Hu Robin B Gasser The mitochondrial genome of Toxocara canis. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Toxocara canis (Ascaridida: Nematoda), which parasitizes (at the adult stage) the small intestine of canids, can be transmitted to a range of other mammals, including humans, and can cause the disease toxocariasis. Despite its significance as a pathogen, the genetics, epidemiology and biology of this parasite remain poorly understood. In addition, the zoonotic potential of related species of Toxocara, such as T. cati and T. malaysiensis, is not well known. Mitochondrial DNA is known to provide genetic markers for investigations in these areas, but complete mitochondrial genomic data have been lacking for T. canis and its congeners. In the present study, the mitochondrial genome of T. canis was amplified by long-range polymerase chain reaction (long PCR) and sequenced using a primer-walking strategy. This circular mitochondrial genome was 14162 bp and contained 12 protein-coding, 22 transfer RNA, and 2 ribosomal RNA genes consistent for secementean nematodes, including Ascaris suum and Anisakis simplex (Ascaridida). The mitochondrial genome of T. canis provides genetic markers for studies into the systematics, population genetics and epidemiology of this zoonotic parasite and its congeners. Such markers can now be used in prospecting for cryptic species and for exploring host specificity and zoonotic potential, thus underpinning the prevention and control of toxocariasis in humans and other hosts. |
format |
Article in Journal/Newspaper |
author |
Aaron R Jex Andrea Waeschenbach D Timothy J Littlewood Min Hu Robin B Gasser |
author_facet |
Aaron R Jex Andrea Waeschenbach D Timothy J Littlewood Min Hu Robin B Gasser |
author_sort |
Aaron R Jex |
title |
The mitochondrial genome of Toxocara canis. |
title_short |
The mitochondrial genome of Toxocara canis. |
title_full |
The mitochondrial genome of Toxocara canis. |
title_fullStr |
The mitochondrial genome of Toxocara canis. |
title_full_unstemmed |
The mitochondrial genome of Toxocara canis. |
title_sort |
mitochondrial genome of toxocara canis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2008 |
url |
https://doi.org/10.1371/journal.pntd.0000273 https://doaj.org/article/9d3c0123b7104f82820a31b4f749f5a0 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 2, Iss 8, p e273 (2008) |
op_relation |
http://europepmc.org/articles/PMC2483351?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000273 https://doaj.org/article/9d3c0123b7104f82820a31b4f749f5a0 |
op_doi |
https://doi.org/10.1371/journal.pntd.0000273 |
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PLoS Neglected Tropical Diseases |
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8 |
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e273 |
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