Toll-Like Receptor Evolution: Does Temperature Matter?
Toll-like receptors (TLRs) recognize conserved pathogen-associated molecular patterns (PAMPs) and are an ancient and well-conserved group of pattern recognition receptors (PRRs). The isolation of the Antarctic continent and its unique teleost fish and microbiota prompted the present investigation in...
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ftdoajarticles:oai:doaj.org/article:9d352ea4375745c699df072e074e54d1 2023-05-15T14:03:11+02:00 Toll-Like Receptor Evolution: Does Temperature Matter? Cármen Sousa Stefan A. Fernandes João C. R. Cardoso Ying Wang Wanying Zhai Pedro M. Guerreiro Liangbiao Chen Adelino V. M. Canário Deborah M. Power 2022-02-01T00:00:00Z https://doi.org/10.3389/fimmu.2022.812890 https://doaj.org/article/9d352ea4375745c699df072e074e54d1 EN eng Frontiers Media S.A. https://www.frontiersin.org/articles/10.3389/fimmu.2022.812890/full https://doaj.org/toc/1664-3224 1664-3224 doi:10.3389/fimmu.2022.812890 https://doaj.org/article/9d352ea4375745c699df072e074e54d1 Frontiers in Immunology, Vol 13 (2022) TLR Antarctic fish innate immunity immune challenge cold temperature evolution Immunologic diseases. Allergy RC581-607 article 2022 ftdoajarticles https://doi.org/10.3389/fimmu.2022.812890 2022-12-31T04:09:16Z Toll-like receptors (TLRs) recognize conserved pathogen-associated molecular patterns (PAMPs) and are an ancient and well-conserved group of pattern recognition receptors (PRRs). The isolation of the Antarctic continent and its unique teleost fish and microbiota prompted the present investigation into Tlr evolution. Gene homologues of tlr members in teleosts from temperate regions were present in the genome of Antarctic Nototheniidae and the non-Antarctic sister lineage Bovichtidae. Overall, in Nototheniidae apart from D. mawsoni, no major tlr gene family expansion or contraction occurred. Instead, lineage and species-specific changes in the ectodomain and LRR of Tlrs occurred, particularly in the Tlr11 superfamily that is well represented in fish. Positive selective pressure and associated sequence modifications in the TLR ectodomain and within the leucine-rich repeats (LRR), important for pathogen recognition, occurred in Tlr5, Tlr8, Tlr13, Tlr21, Tlr22, and Tlr23 presumably associated with the unique Antarctic microbiota. Exposure to lipopolysaccharide (Escherichia coli O111:B4) Gram negative bacteria did not modify tlr gene expression in N. rossii head–kidney or anterior intestine, although increased water temperature (+4°C) had a significant effect. Article in Journal/Newspaper Antarc* Antarctic Directory of Open Access Journals: DOAJ Articles Antarctic The Antarctic Frontiers in Immunology 13 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
TLR Antarctic fish innate immunity immune challenge cold temperature evolution Immunologic diseases. Allergy RC581-607 |
spellingShingle |
TLR Antarctic fish innate immunity immune challenge cold temperature evolution Immunologic diseases. Allergy RC581-607 Cármen Sousa Stefan A. Fernandes João C. R. Cardoso Ying Wang Wanying Zhai Pedro M. Guerreiro Liangbiao Chen Adelino V. M. Canário Deborah M. Power Toll-Like Receptor Evolution: Does Temperature Matter? |
topic_facet |
TLR Antarctic fish innate immunity immune challenge cold temperature evolution Immunologic diseases. Allergy RC581-607 |
description |
Toll-like receptors (TLRs) recognize conserved pathogen-associated molecular patterns (PAMPs) and are an ancient and well-conserved group of pattern recognition receptors (PRRs). The isolation of the Antarctic continent and its unique teleost fish and microbiota prompted the present investigation into Tlr evolution. Gene homologues of tlr members in teleosts from temperate regions were present in the genome of Antarctic Nototheniidae and the non-Antarctic sister lineage Bovichtidae. Overall, in Nototheniidae apart from D. mawsoni, no major tlr gene family expansion or contraction occurred. Instead, lineage and species-specific changes in the ectodomain and LRR of Tlrs occurred, particularly in the Tlr11 superfamily that is well represented in fish. Positive selective pressure and associated sequence modifications in the TLR ectodomain and within the leucine-rich repeats (LRR), important for pathogen recognition, occurred in Tlr5, Tlr8, Tlr13, Tlr21, Tlr22, and Tlr23 presumably associated with the unique Antarctic microbiota. Exposure to lipopolysaccharide (Escherichia coli O111:B4) Gram negative bacteria did not modify tlr gene expression in N. rossii head–kidney or anterior intestine, although increased water temperature (+4°C) had a significant effect. |
format |
Article in Journal/Newspaper |
author |
Cármen Sousa Stefan A. Fernandes João C. R. Cardoso Ying Wang Wanying Zhai Pedro M. Guerreiro Liangbiao Chen Adelino V. M. Canário Deborah M. Power |
author_facet |
Cármen Sousa Stefan A. Fernandes João C. R. Cardoso Ying Wang Wanying Zhai Pedro M. Guerreiro Liangbiao Chen Adelino V. M. Canário Deborah M. Power |
author_sort |
Cármen Sousa |
title |
Toll-Like Receptor Evolution: Does Temperature Matter? |
title_short |
Toll-Like Receptor Evolution: Does Temperature Matter? |
title_full |
Toll-Like Receptor Evolution: Does Temperature Matter? |
title_fullStr |
Toll-Like Receptor Evolution: Does Temperature Matter? |
title_full_unstemmed |
Toll-Like Receptor Evolution: Does Temperature Matter? |
title_sort |
toll-like receptor evolution: does temperature matter? |
publisher |
Frontiers Media S.A. |
publishDate |
2022 |
url |
https://doi.org/10.3389/fimmu.2022.812890 https://doaj.org/article/9d352ea4375745c699df072e074e54d1 |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
Frontiers in Immunology, Vol 13 (2022) |
op_relation |
https://www.frontiersin.org/articles/10.3389/fimmu.2022.812890/full https://doaj.org/toc/1664-3224 1664-3224 doi:10.3389/fimmu.2022.812890 https://doaj.org/article/9d352ea4375745c699df072e074e54d1 |
op_doi |
https://doi.org/10.3389/fimmu.2022.812890 |
container_title |
Frontiers in Immunology |
container_volume |
13 |
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1766273741063454720 |