Invasive fungal infection in patients with hematologic disorders in a Brazilian tertiary care hospital
ABSTRACT INTRODUCTION: Invasive fungal infections (IFIs) are an important complication in immunocompromised individuals, particularly neutropenic patients with hematological malignancies. In this study, we aimed to verify the epidemiology and diagnosis of IFIs in patients with hematologic problems a...
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ftdoajarticles:oai:doaj.org/article:9d26ca4c2d6649a4a249fb4b991fb14c 2023-05-15T15:11:29+02:00 Invasive fungal infection in patients with hematologic disorders in a Brazilian tertiary care hospital Milton Camplesi Junior Hildene Meneses Silva Adriano Moraes Arantes Carolina Rodrigues Costa Fábio Silvestre Ataides Thaisa Cristina Silva Maysa de Paula Costa dos Reis Maria do Rosário Rodrigues Silva https://doi.org/10.1590/0037-8682-0191-2016 https://doaj.org/article/9d26ca4c2d6649a4a249fb4b991fb14c EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000100080&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0191-2016 https://doaj.org/article/9d26ca4c2d6649a4a249fb4b991fb14c Revista da Sociedade Brasileira de Medicina Tropical, Vol 50, Iss 1, Pp 80-85 Invasive fungal infections Hematologic disease In vitro susceptibility Arctic medicine. Tropical medicine RC955-962 article ftdoajarticles https://doi.org/10.1590/0037-8682-0191-2016 2022-12-30T23:25:43Z ABSTRACT INTRODUCTION: Invasive fungal infections (IFIs) are an important complication in immunocompromised individuals, particularly neutropenic patients with hematological malignancies. In this study, we aimed to verify the epidemiology and diagnosis of IFIs in patients with hematologic problems at a tertiary hospital in Goiânia-GO, Brazil. METHODS: Data from 117 patients, involving 19 cases of IFIs, were collected. The collected data included diagnosis methods, demographics, clinical characteristics, and in vitro susceptibility to different antifungal agents. Among the 19 cases, 12 were classified as proven IFI and 7 as probable invasive aspergillosis with detection of galactomannan in blood and presence of lung infiltrates in radiographic images. Logistic regression analysis showed that the proven and probable IFIs were associated with increased risk of death. Statistical analysis demonstrated that age, sex, and underlying disease were not independently associated with risk of death in IFI patients. RESULTS: Most bloodstream isolates of Candida spp. exhibited low minimum inhibitory concentrations (MICs) to all antifungal agents tested. Voriconazole and amphotericin had the lowest MICs for Aspergillus spp. and Fusarium spp., but Fusarium spp. showed the least susceptibility to all antifungals tested. Amphotericin B, fluconazole, and itraconazole were found to be inactive in vitro against Acremonium kiliense; but this fungus was sensitive to voriconazole. CONCLUSIONS: Considering the high number of IFI cases, with crude mortality rate of 6%, we could conclude that IFIs remain a common infection in patients with hematological malignancies and underdiagnosed ante mortem. Thus, IFIs should be monitored closely. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 50 1 80 85 |
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Invasive fungal infections Hematologic disease In vitro susceptibility Arctic medicine. Tropical medicine RC955-962 |
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Invasive fungal infections Hematologic disease In vitro susceptibility Arctic medicine. Tropical medicine RC955-962 Milton Camplesi Junior Hildene Meneses Silva Adriano Moraes Arantes Carolina Rodrigues Costa Fábio Silvestre Ataides Thaisa Cristina Silva Maysa de Paula Costa dos Reis Maria do Rosário Rodrigues Silva Invasive fungal infection in patients with hematologic disorders in a Brazilian tertiary care hospital |
topic_facet |
Invasive fungal infections Hematologic disease In vitro susceptibility Arctic medicine. Tropical medicine RC955-962 |
description |
ABSTRACT INTRODUCTION: Invasive fungal infections (IFIs) are an important complication in immunocompromised individuals, particularly neutropenic patients with hematological malignancies. In this study, we aimed to verify the epidemiology and diagnosis of IFIs in patients with hematologic problems at a tertiary hospital in Goiânia-GO, Brazil. METHODS: Data from 117 patients, involving 19 cases of IFIs, were collected. The collected data included diagnosis methods, demographics, clinical characteristics, and in vitro susceptibility to different antifungal agents. Among the 19 cases, 12 were classified as proven IFI and 7 as probable invasive aspergillosis with detection of galactomannan in blood and presence of lung infiltrates in radiographic images. Logistic regression analysis showed that the proven and probable IFIs were associated with increased risk of death. Statistical analysis demonstrated that age, sex, and underlying disease were not independently associated with risk of death in IFI patients. RESULTS: Most bloodstream isolates of Candida spp. exhibited low minimum inhibitory concentrations (MICs) to all antifungal agents tested. Voriconazole and amphotericin had the lowest MICs for Aspergillus spp. and Fusarium spp., but Fusarium spp. showed the least susceptibility to all antifungals tested. Amphotericin B, fluconazole, and itraconazole were found to be inactive in vitro against Acremonium kiliense; but this fungus was sensitive to voriconazole. CONCLUSIONS: Considering the high number of IFI cases, with crude mortality rate of 6%, we could conclude that IFIs remain a common infection in patients with hematological malignancies and underdiagnosed ante mortem. Thus, IFIs should be monitored closely. |
format |
Article in Journal/Newspaper |
author |
Milton Camplesi Junior Hildene Meneses Silva Adriano Moraes Arantes Carolina Rodrigues Costa Fábio Silvestre Ataides Thaisa Cristina Silva Maysa de Paula Costa dos Reis Maria do Rosário Rodrigues Silva |
author_facet |
Milton Camplesi Junior Hildene Meneses Silva Adriano Moraes Arantes Carolina Rodrigues Costa Fábio Silvestre Ataides Thaisa Cristina Silva Maysa de Paula Costa dos Reis Maria do Rosário Rodrigues Silva |
author_sort |
Milton Camplesi Junior |
title |
Invasive fungal infection in patients with hematologic disorders in a Brazilian tertiary care hospital |
title_short |
Invasive fungal infection in patients with hematologic disorders in a Brazilian tertiary care hospital |
title_full |
Invasive fungal infection in patients with hematologic disorders in a Brazilian tertiary care hospital |
title_fullStr |
Invasive fungal infection in patients with hematologic disorders in a Brazilian tertiary care hospital |
title_full_unstemmed |
Invasive fungal infection in patients with hematologic disorders in a Brazilian tertiary care hospital |
title_sort |
invasive fungal infection in patients with hematologic disorders in a brazilian tertiary care hospital |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
url |
https://doi.org/10.1590/0037-8682-0191-2016 https://doaj.org/article/9d26ca4c2d6649a4a249fb4b991fb14c |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 50, Iss 1, Pp 80-85 |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000100080&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0191-2016 https://doaj.org/article/9d26ca4c2d6649a4a249fb4b991fb14c |
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https://doi.org/10.1590/0037-8682-0191-2016 |
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