Of mice, cattle, and humans: the immunology and treatment of river blindness.
River blindness is a seriously debilitating disease caused by the filarial parasite Onchocerca volvulus, which infects millions in Africa as well as in South and Central America. Research has been hampered by a lack of good animal models, as the parasite can only develop fully in humans and some pri...
Published in: | PLoS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2008
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0000217 https://doaj.org/article/9d1f33605a1b4e62a09a3c957b063a9e |
id |
ftdoajarticles:oai:doaj.org/article:9d1f33605a1b4e62a09a3c957b063a9e |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:9d1f33605a1b4e62a09a3c957b063a9e 2023-05-15T15:01:22+02:00 Of mice, cattle, and humans: the immunology and treatment of river blindness. Judith E Allen Ohene Adjei Odile Bain Achim Hoerauf Wolfgang H Hoffmann Benjamin L Makepeace Hartwig Schulz-Key Vincent N Tanya Alexander J Trees Samuel Wanji David W Taylor 2008-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000217 https://doaj.org/article/9d1f33605a1b4e62a09a3c957b063a9e EN eng Public Library of Science (PLoS) https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18446236/pdf/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000217 https://doaj.org/article/9d1f33605a1b4e62a09a3c957b063a9e PLoS Neglected Tropical Diseases, Vol 2, Iss 4, p e217 (2008) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2008 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000217 2022-12-31T10:12:34Z River blindness is a seriously debilitating disease caused by the filarial parasite Onchocerca volvulus, which infects millions in Africa as well as in South and Central America. Research has been hampered by a lack of good animal models, as the parasite can only develop fully in humans and some primates. This review highlights the development of two animal model systems that have allowed significant advances in recent years and hold promise for the future. Experimental findings with Litomosoides sigmodontis in mice and Onchocerca ochengi in cattle are placed in the context of how these models can advance our ability to control the human disease. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 2 4 e217 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Judith E Allen Ohene Adjei Odile Bain Achim Hoerauf Wolfgang H Hoffmann Benjamin L Makepeace Hartwig Schulz-Key Vincent N Tanya Alexander J Trees Samuel Wanji David W Taylor Of mice, cattle, and humans: the immunology and treatment of river blindness. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
River blindness is a seriously debilitating disease caused by the filarial parasite Onchocerca volvulus, which infects millions in Africa as well as in South and Central America. Research has been hampered by a lack of good animal models, as the parasite can only develop fully in humans and some primates. This review highlights the development of two animal model systems that have allowed significant advances in recent years and hold promise for the future. Experimental findings with Litomosoides sigmodontis in mice and Onchocerca ochengi in cattle are placed in the context of how these models can advance our ability to control the human disease. |
format |
Article in Journal/Newspaper |
author |
Judith E Allen Ohene Adjei Odile Bain Achim Hoerauf Wolfgang H Hoffmann Benjamin L Makepeace Hartwig Schulz-Key Vincent N Tanya Alexander J Trees Samuel Wanji David W Taylor |
author_facet |
Judith E Allen Ohene Adjei Odile Bain Achim Hoerauf Wolfgang H Hoffmann Benjamin L Makepeace Hartwig Schulz-Key Vincent N Tanya Alexander J Trees Samuel Wanji David W Taylor |
author_sort |
Judith E Allen |
title |
Of mice, cattle, and humans: the immunology and treatment of river blindness. |
title_short |
Of mice, cattle, and humans: the immunology and treatment of river blindness. |
title_full |
Of mice, cattle, and humans: the immunology and treatment of river blindness. |
title_fullStr |
Of mice, cattle, and humans: the immunology and treatment of river blindness. |
title_full_unstemmed |
Of mice, cattle, and humans: the immunology and treatment of river blindness. |
title_sort |
of mice, cattle, and humans: the immunology and treatment of river blindness. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2008 |
url |
https://doi.org/10.1371/journal.pntd.0000217 https://doaj.org/article/9d1f33605a1b4e62a09a3c957b063a9e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 2, Iss 4, p e217 (2008) |
op_relation |
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18446236/pdf/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000217 https://doaj.org/article/9d1f33605a1b4e62a09a3c957b063a9e |
op_doi |
https://doi.org/10.1371/journal.pntd.0000217 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
2 |
container_issue |
4 |
container_start_page |
e217 |
_version_ |
1766333401670877184 |