Decision-model estimation of the age-specific disability weight for schistosomiasis japonica: a systematic review of the literature.
Schistosomiasis is among the most prevalent parasitic infections worldwide. However, current Global Burden of Disease (GBD) disability-adjusted life year estimates indicate that its population-level impact is negligible. Recent studies suggest that GBD methodologies may significantly underestimate t...
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ftdoajarticles:oai:doaj.org/article:9cfa0f4698034685975e20a2df99b6eb 2023-05-15T15:11:59+02:00 Decision-model estimation of the age-specific disability weight for schistosomiasis japonica: a systematic review of the literature. Julia L Finkelstein Mark D Schleinitz Hélène Carabin Stephen T McGarvey 2008-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000158 https://doaj.org/article/9cfa0f4698034685975e20a2df99b6eb EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2254314?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000158 https://doaj.org/article/9cfa0f4698034685975e20a2df99b6eb PLoS Neglected Tropical Diseases, Vol 2, Iss 3, p e158 (2008) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2008 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000158 2022-12-31T12:56:57Z Schistosomiasis is among the most prevalent parasitic infections worldwide. However, current Global Burden of Disease (GBD) disability-adjusted life year estimates indicate that its population-level impact is negligible. Recent studies suggest that GBD methodologies may significantly underestimate the burden of parasitic diseases, including schistosomiasis. Furthermore, strain-specific disability weights have not been established for schistosomiasis, and the magnitude of human disease burden due to Schistosoma japonicum remains controversial. We used a decision model to quantify an alternative disability weight estimate of the burden of human disease due to S. japonicum. We reviewed S. japonicum morbidity data, and constructed decision trees for all infected persons and two age-specific strata, <15 years (y) and > or =15 y. We conducted stochastic and probabilistic sensitivity analyses for each model. Infection with S. japonicum was associated with an average disability weight of 0.132, with age-specific disability weights of 0.098 (<15 y) and 0.186 (> or =15 y). Re-estimated disability weights were seven to 46 times greater than current GBD measures; no simulations produced disability weight estimates lower than 0.009. Nutritional morbidities had the greatest contribution to the S. japonicum disability weight in the <15 y model, whereas major organ pathologies were the most critical variables in the older age group. GBD disability weights for schistosomiasis urgently need to be revised, and species-specific disability weights should be established. Even a marginal increase in current estimates would result in a substantial rise in the estimated global burden of schistosomiasis, and have considerable implications for public health prioritization and resource allocation for schistosomiasis research, monitoring, and control. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 2 3 e158 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Julia L Finkelstein Mark D Schleinitz Hélène Carabin Stephen T McGarvey Decision-model estimation of the age-specific disability weight for schistosomiasis japonica: a systematic review of the literature. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Schistosomiasis is among the most prevalent parasitic infections worldwide. However, current Global Burden of Disease (GBD) disability-adjusted life year estimates indicate that its population-level impact is negligible. Recent studies suggest that GBD methodologies may significantly underestimate the burden of parasitic diseases, including schistosomiasis. Furthermore, strain-specific disability weights have not been established for schistosomiasis, and the magnitude of human disease burden due to Schistosoma japonicum remains controversial. We used a decision model to quantify an alternative disability weight estimate of the burden of human disease due to S. japonicum. We reviewed S. japonicum morbidity data, and constructed decision trees for all infected persons and two age-specific strata, <15 years (y) and > or =15 y. We conducted stochastic and probabilistic sensitivity analyses for each model. Infection with S. japonicum was associated with an average disability weight of 0.132, with age-specific disability weights of 0.098 (<15 y) and 0.186 (> or =15 y). Re-estimated disability weights were seven to 46 times greater than current GBD measures; no simulations produced disability weight estimates lower than 0.009. Nutritional morbidities had the greatest contribution to the S. japonicum disability weight in the <15 y model, whereas major organ pathologies were the most critical variables in the older age group. GBD disability weights for schistosomiasis urgently need to be revised, and species-specific disability weights should be established. Even a marginal increase in current estimates would result in a substantial rise in the estimated global burden of schistosomiasis, and have considerable implications for public health prioritization and resource allocation for schistosomiasis research, monitoring, and control. |
format |
Article in Journal/Newspaper |
author |
Julia L Finkelstein Mark D Schleinitz Hélène Carabin Stephen T McGarvey |
author_facet |
Julia L Finkelstein Mark D Schleinitz Hélène Carabin Stephen T McGarvey |
author_sort |
Julia L Finkelstein |
title |
Decision-model estimation of the age-specific disability weight for schistosomiasis japonica: a systematic review of the literature. |
title_short |
Decision-model estimation of the age-specific disability weight for schistosomiasis japonica: a systematic review of the literature. |
title_full |
Decision-model estimation of the age-specific disability weight for schistosomiasis japonica: a systematic review of the literature. |
title_fullStr |
Decision-model estimation of the age-specific disability weight for schistosomiasis japonica: a systematic review of the literature. |
title_full_unstemmed |
Decision-model estimation of the age-specific disability weight for schistosomiasis japonica: a systematic review of the literature. |
title_sort |
decision-model estimation of the age-specific disability weight for schistosomiasis japonica: a systematic review of the literature. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2008 |
url |
https://doi.org/10.1371/journal.pntd.0000158 https://doaj.org/article/9cfa0f4698034685975e20a2df99b6eb |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 2, Iss 3, p e158 (2008) |
op_relation |
http://europepmc.org/articles/PMC2254314?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000158 https://doaj.org/article/9cfa0f4698034685975e20a2df99b6eb |
op_doi |
https://doi.org/10.1371/journal.pntd.0000158 |
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PLoS Neglected Tropical Diseases |
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2 |
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3 |
container_start_page |
e158 |
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