Evaluation of the in vitro activity of six antimicrobial agents against Neisseria gonorrhoeae Avaliação in vitro da atividade de seis drogas antimicrobianas contra Neisseria gonorrhoeae
Use of antimicrobials for the treatment of gonorrhea started in 1930 with the utilization of sulfonamides. With the years other drugs were used for its treatment such as penicillin, tetracycline, spectinomycin, and others. Although highly specific in the beginning, these drugs, with time did not sho...
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Universidade de São Paulo (USP)
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ftdoajarticles:oai:doaj.org/article:9cacac8ba80942fcad3276fcb7797baf 2024-09-09T19:28:08+00:00 Evaluation of the in vitro activity of six antimicrobial agents against Neisseria gonorrhoeae Avaliação in vitro da atividade de seis drogas antimicrobianas contra Neisseria gonorrhoeae Walter Belda Junior Paulo Eduardo Neves Ferreira Velho Luiz Jorge Fagundes Marcelo Arnone 2007-02-01T00:00:00Z https://doi.org/10.1590/S0036-46652007000100010 https://doaj.org/article/9cacac8ba80942fcad3276fcb7797baf EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652007000100010 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652007000100010 0036-4665 1678-9946 https://doaj.org/article/9cacac8ba80942fcad3276fcb7797baf Revista do Instituto de Medicina Tropical de São Paulo, Vol 49, Iss 1, Pp 55-58 (2007) Gonorrhea Neisseria gonorrhoeae Drug resistance Minimum inhibitory concentration Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2007 ftdoajarticles https://doi.org/10.1590/S0036-46652007000100010 2024-08-05T17:49:30Z Use of antimicrobials for the treatment of gonorrhea started in 1930 with the utilization of sulfonamides. With the years other drugs were used for its treatment such as penicillin, tetracycline, spectinomycin, and others. Although highly specific in the beginning, these drugs, with time did not show anymore the expected therapeutic results because of aspects of chromosomal and plasmid-mediated resistance. The purpose of this study was to evaluate the susceptibility of Neisseria gonorrhoeae strains to six drugs used for its treatment (penicillin, tetracycline, cefoxitin, thiamphenicol, spectinomycin and ofloxacin) by the determination of minimal inhibitory concentrations of these drugs. We concluded that drugs, such as cefoxitin, thiamphenicol and spectinomycin still are excellent pharmacological agents for the treatment of gonorrhea. Penicillin, although still efficient, needs more attention regarding its use, as well as ofloxacin, because of the emergence of resistant strains. Tetracycline and its derivatives should be strongly contraindicated for the treatment of gonorrhea. A utilização de antimicrobianos no tratamento da gonorréia iniciou-se em 1930 com a utilização das sulfonamidas. No decorrer dos anos outras drogas passaram a ser utilizadas em seu tratamento como a penicilina, tetraciclina, espectinomicina e outras. Embora altamente eficazes no início, essas drogas, ao longo do tempo, passaram a não mais apresentar o resultado terapêutico esperado em virtude do aparecimento de quadros de resistência cromossômica e plasmidial. Este trabalho teve por objetivo avaliar a sensibilidade de cepas de Neisseria gonorrhoeae a seis drogas utilizadas no seu tratamento (penicilina, tetraciclina, cefoxitina, tianfenicol, espectinomicina e ofloxacina) através da concentração inibitória mínima. Concluimos que drogas como a cefoxitina, o tianfenicol e a espectinomicina ainda constituem excelentes fármacos para o tratamento da gonorréia. A penicilina, embora ainda eficaz, enseja maiores cuidados na sua utilização, assim ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 49 1 55 58 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Gonorrhea Neisseria gonorrhoeae Drug resistance Minimum inhibitory concentration Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Gonorrhea Neisseria gonorrhoeae Drug resistance Minimum inhibitory concentration Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Walter Belda Junior Paulo Eduardo Neves Ferreira Velho Luiz Jorge Fagundes Marcelo Arnone Evaluation of the in vitro activity of six antimicrobial agents against Neisseria gonorrhoeae Avaliação in vitro da atividade de seis drogas antimicrobianas contra Neisseria gonorrhoeae |
topic_facet |
Gonorrhea Neisseria gonorrhoeae Drug resistance Minimum inhibitory concentration Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Use of antimicrobials for the treatment of gonorrhea started in 1930 with the utilization of sulfonamides. With the years other drugs were used for its treatment such as penicillin, tetracycline, spectinomycin, and others. Although highly specific in the beginning, these drugs, with time did not show anymore the expected therapeutic results because of aspects of chromosomal and plasmid-mediated resistance. The purpose of this study was to evaluate the susceptibility of Neisseria gonorrhoeae strains to six drugs used for its treatment (penicillin, tetracycline, cefoxitin, thiamphenicol, spectinomycin and ofloxacin) by the determination of minimal inhibitory concentrations of these drugs. We concluded that drugs, such as cefoxitin, thiamphenicol and spectinomycin still are excellent pharmacological agents for the treatment of gonorrhea. Penicillin, although still efficient, needs more attention regarding its use, as well as ofloxacin, because of the emergence of resistant strains. Tetracycline and its derivatives should be strongly contraindicated for the treatment of gonorrhea. A utilização de antimicrobianos no tratamento da gonorréia iniciou-se em 1930 com a utilização das sulfonamidas. No decorrer dos anos outras drogas passaram a ser utilizadas em seu tratamento como a penicilina, tetraciclina, espectinomicina e outras. Embora altamente eficazes no início, essas drogas, ao longo do tempo, passaram a não mais apresentar o resultado terapêutico esperado em virtude do aparecimento de quadros de resistência cromossômica e plasmidial. Este trabalho teve por objetivo avaliar a sensibilidade de cepas de Neisseria gonorrhoeae a seis drogas utilizadas no seu tratamento (penicilina, tetraciclina, cefoxitina, tianfenicol, espectinomicina e ofloxacina) através da concentração inibitória mínima. Concluimos que drogas como a cefoxitina, o tianfenicol e a espectinomicina ainda constituem excelentes fármacos para o tratamento da gonorréia. A penicilina, embora ainda eficaz, enseja maiores cuidados na sua utilização, assim ... |
format |
Article in Journal/Newspaper |
author |
Walter Belda Junior Paulo Eduardo Neves Ferreira Velho Luiz Jorge Fagundes Marcelo Arnone |
author_facet |
Walter Belda Junior Paulo Eduardo Neves Ferreira Velho Luiz Jorge Fagundes Marcelo Arnone |
author_sort |
Walter Belda Junior |
title |
Evaluation of the in vitro activity of six antimicrobial agents against Neisseria gonorrhoeae Avaliação in vitro da atividade de seis drogas antimicrobianas contra Neisseria gonorrhoeae |
title_short |
Evaluation of the in vitro activity of six antimicrobial agents against Neisseria gonorrhoeae Avaliação in vitro da atividade de seis drogas antimicrobianas contra Neisseria gonorrhoeae |
title_full |
Evaluation of the in vitro activity of six antimicrobial agents against Neisseria gonorrhoeae Avaliação in vitro da atividade de seis drogas antimicrobianas contra Neisseria gonorrhoeae |
title_fullStr |
Evaluation of the in vitro activity of six antimicrobial agents against Neisseria gonorrhoeae Avaliação in vitro da atividade de seis drogas antimicrobianas contra Neisseria gonorrhoeae |
title_full_unstemmed |
Evaluation of the in vitro activity of six antimicrobial agents against Neisseria gonorrhoeae Avaliação in vitro da atividade de seis drogas antimicrobianas contra Neisseria gonorrhoeae |
title_sort |
evaluation of the in vitro activity of six antimicrobial agents against neisseria gonorrhoeae avaliação in vitro da atividade de seis drogas antimicrobianas contra neisseria gonorrhoeae |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2007 |
url |
https://doi.org/10.1590/S0036-46652007000100010 https://doaj.org/article/9cacac8ba80942fcad3276fcb7797baf |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 49, Iss 1, Pp 55-58 (2007) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652007000100010 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652007000100010 0036-4665 1678-9946 https://doaj.org/article/9cacac8ba80942fcad3276fcb7797baf |
op_doi |
https://doi.org/10.1590/S0036-46652007000100010 |
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Revista do Instituto de Medicina Tropical de São Paulo |
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49 |
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