Polymorphism of apolipoprotein A1 gene and lipid profile of blood serum in the Evenki and Buryat populations

• Main Authors: S. I. Kolesnikov, T. A. Bairova, O. V. Kalyuzhnaya, A. A. Trukhin, O. A. Ershova, M. A. Darenskaya
• Format: Article in Journal/Newspaper
• Language: Russian
• Published: Scientific Сentre for Family Health and Human Reproduction Problems 2015
• Subjects: apolipoprotein; lipids; gene; Science; Q; Evenki; Siberia
• Online Access: https://doaj.org/article/9c7d11e0d51749b49361b6b0e435dd10

The prevalence of genotypes and alleles of polymorphic markers (-75)G>A and (+83)C>T apolipoprotein A1 gene (ApOAl) in samples of ethnic groups from Eastern Siberia (the Evenkis and Buryats) were studied. In the Evenki population allele (-75)A was registered in 22,7 % cases, in the Buryat population - in 22,4 % cases. In the Evenki population allele (+83)T was found in 6,3 % cases, in the Buryat population - in 5,9 % cases. Statistically significant differences of genotypes and alleles APOA1 prevalence between the Evenkis and the Buryats was not found. The prevalence of alleles (-75)G>A and (+83)C>T of gene APOA1 obtained in the study were compared with the prevalence in different populations around the world. For each teenager in the study group we conducted a biochemical analysis of serum lipid profile. Also a comparative analysis of blood lipid profile in carriers of different genotypes was carried out. Comparative analysis of blood lipid profile in carriers of different genotypes was conducted.