A systematic review and meta-analysis to assess the association between urogenital schistosomiasis and HIV/AIDS infection.
Background Urogenital schistosomiasis and HIV/AIDS infections are widespread in sub-Saharan Africa (SSA) leading to substantial morbidity and mortality. The co-occurrence of both diseases has led to the possible hypothesis that urogenital schistosomiasis leads to increased risk of acquiring HIV infe...
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ftdoajarticles:oai:doaj.org/article:9c3db962793447f6a53e5047539bb785 2023-05-15T15:15:12+02:00 A systematic review and meta-analysis to assess the association between urogenital schistosomiasis and HIV/AIDS infection. Ludoviko Zirimenya Fatima Mahmud-Ajeigbe Ruth McQuillan You Li 2020-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008383 https://doaj.org/article/9c3db962793447f6a53e5047539bb785 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008383 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008383 https://doaj.org/article/9c3db962793447f6a53e5047539bb785 PLoS Neglected Tropical Diseases, Vol 14, Iss 6, p e0008383 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008383 2022-12-31T13:48:05Z Background Urogenital schistosomiasis and HIV/AIDS infections are widespread in sub-Saharan Africa (SSA) leading to substantial morbidity and mortality. The co-occurrence of both diseases has led to the possible hypothesis that urogenital schistosomiasis leads to increased risk of acquiring HIV infection. However, the available evidence concerning this association is inconsistent. The aim of this study was to systematically review and quantitatively synthesize studies that investigated the association between urogenital schistosomiasis and HIV/AIDS infection. Methods A systematic review basing on PRISMA guidelines was conducted. It is registered with PROSPERO, number CRD42018116648. We searched four databases, MEDLINE, EMBASE, Global Health and Global Index Medicus for studies investigating the association between urogenital schistosomiasis and HIV infection. Only studies published in English were considered. Results of the association were summarised by gender. A meta-analysis was performed for studies on females using random-effects model and a pooled OR with 95% confidence interval was reported. Results Of the 993 studies screened, only eight observational studies met the inclusion criteria. Across all studies, the reported unadjusted OR ranged from 0.78 to 3.76. The pooled estimate of unadjusted OR among females was 1.31 (95% CI: 0.87-1.99). Only four of the eight studies reported an adjusted OR. A separate meta-analysis done in the three studies among females that reported an adjusted OR showed that the pooled estimate was 1.85 (95% CI: 1.17-2.92). There were insufficient data to pool results for association between urogenital schistosomiasis and HIV infection in the males. Conclusion Our investigation supports the hypothesis of an association between urogenital schistosomiasis with HIV/AIDS infection in females. Due to insufficient evidence, no conclusion could be drawn in males with urogenital schistosomiasis. Large-scale prospective studies are needed in future. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Prisma ENVELOPE(-58.767,-58.767,-69.200,-69.200) PLOS Neglected Tropical Diseases 14 6 e0008383 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ludoviko Zirimenya Fatima Mahmud-Ajeigbe Ruth McQuillan You Li A systematic review and meta-analysis to assess the association between urogenital schistosomiasis and HIV/AIDS infection. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Urogenital schistosomiasis and HIV/AIDS infections are widespread in sub-Saharan Africa (SSA) leading to substantial morbidity and mortality. The co-occurrence of both diseases has led to the possible hypothesis that urogenital schistosomiasis leads to increased risk of acquiring HIV infection. However, the available evidence concerning this association is inconsistent. The aim of this study was to systematically review and quantitatively synthesize studies that investigated the association between urogenital schistosomiasis and HIV/AIDS infection. Methods A systematic review basing on PRISMA guidelines was conducted. It is registered with PROSPERO, number CRD42018116648. We searched four databases, MEDLINE, EMBASE, Global Health and Global Index Medicus for studies investigating the association between urogenital schistosomiasis and HIV infection. Only studies published in English were considered. Results of the association were summarised by gender. A meta-analysis was performed for studies on females using random-effects model and a pooled OR with 95% confidence interval was reported. Results Of the 993 studies screened, only eight observational studies met the inclusion criteria. Across all studies, the reported unadjusted OR ranged from 0.78 to 3.76. The pooled estimate of unadjusted OR among females was 1.31 (95% CI: 0.87-1.99). Only four of the eight studies reported an adjusted OR. A separate meta-analysis done in the three studies among females that reported an adjusted OR showed that the pooled estimate was 1.85 (95% CI: 1.17-2.92). There were insufficient data to pool results for association between urogenital schistosomiasis and HIV infection in the males. Conclusion Our investigation supports the hypothesis of an association between urogenital schistosomiasis with HIV/AIDS infection in females. Due to insufficient evidence, no conclusion could be drawn in males with urogenital schistosomiasis. Large-scale prospective studies are needed in future. |
format |
Article in Journal/Newspaper |
author |
Ludoviko Zirimenya Fatima Mahmud-Ajeigbe Ruth McQuillan You Li |
author_facet |
Ludoviko Zirimenya Fatima Mahmud-Ajeigbe Ruth McQuillan You Li |
author_sort |
Ludoviko Zirimenya |
title |
A systematic review and meta-analysis to assess the association between urogenital schistosomiasis and HIV/AIDS infection. |
title_short |
A systematic review and meta-analysis to assess the association between urogenital schistosomiasis and HIV/AIDS infection. |
title_full |
A systematic review and meta-analysis to assess the association between urogenital schistosomiasis and HIV/AIDS infection. |
title_fullStr |
A systematic review and meta-analysis to assess the association between urogenital schistosomiasis and HIV/AIDS infection. |
title_full_unstemmed |
A systematic review and meta-analysis to assess the association between urogenital schistosomiasis and HIV/AIDS infection. |
title_sort |
systematic review and meta-analysis to assess the association between urogenital schistosomiasis and hiv/aids infection. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008383 https://doaj.org/article/9c3db962793447f6a53e5047539bb785 |
long_lat |
ENVELOPE(-58.767,-58.767,-69.200,-69.200) |
geographic |
Arctic Prisma |
geographic_facet |
Arctic Prisma |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 6, p e0008383 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008383 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008383 https://doaj.org/article/9c3db962793447f6a53e5047539bb785 |
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https://doi.org/10.1371/journal.pntd.0008383 |
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PLOS Neglected Tropical Diseases |
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14 |
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6 |
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e0008383 |
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