Intake of farmed Atlantic salmon fed soybean oil increases insulin resistance and hepatic lipid accumulation in mice.
BACKGROUND: To ensure sustainable aquaculture, fish derived raw materials are replaced by vegetable ingredients. Fatty acid composition and contaminant status of farmed Atlantic salmon (Salmo salar L.) are affected by the use of plant ingredients and a spillover effect on consumers is thus expected....
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Online Access: | https://doi.org/10.1371/journal.pone.0053094 https://doaj.org/article/9bb5d5e7dc0a44d6bdd2807e13e38515 |
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ftdoajarticles:oai:doaj.org/article:9bb5d5e7dc0a44d6bdd2807e13e38515 2023-05-15T15:29:34+02:00 Intake of farmed Atlantic salmon fed soybean oil increases insulin resistance and hepatic lipid accumulation in mice. Lisa Kolden Midtbø Mohammad Madani Ibrahim Lene Secher Myrmel Ulrike Liisberg Aune Anita Røyneberg Alvheim Nina S Liland Bente E Torstensen Grethe Rosenlund Bjørn Liaset Trond Brattelid Karsten Kristiansen Lise Madsen 2013-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0053094 https://doaj.org/article/9bb5d5e7dc0a44d6bdd2807e13e38515 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3534660?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0053094 https://doaj.org/article/9bb5d5e7dc0a44d6bdd2807e13e38515 PLoS ONE, Vol 8, Iss 1, p e53094 (2013) Medicine R Science Q article 2013 ftdoajarticles https://doi.org/10.1371/journal.pone.0053094 2022-12-31T11:37:24Z BACKGROUND: To ensure sustainable aquaculture, fish derived raw materials are replaced by vegetable ingredients. Fatty acid composition and contaminant status of farmed Atlantic salmon (Salmo salar L.) are affected by the use of plant ingredients and a spillover effect on consumers is thus expected. Here we aimed to compare the effects of intake of Atlantic salmon fed fish oil (FO) with intake of Atlantic salmon fed a high proportion of vegetable oils (VOs) on development of insulin resistance and obesity in mice. METHODOLOGY/PRINCIPAL FINDINGS: Atlantic salmon were fed diets where FO was partly (80%) replaced with three different VOs; rapeseed oil (RO), olive oil (OO) or soy bean oil (SO). Fillets from Atlantic salmon were subsequently used to prepare Western diets (WD) for a mouse feeding trial. Partial replacement of FO with VOs reduced the levels of polychlorinated biphenyls (PCB) and dichloro-diphenyl-tricloroethanes (DDT) with more than 50% in salmon fillets, in WDs containing the fillets, and in white adipose tissue from mice consuming the WDs. Replacement with VOs, SO in particular, lowered the n-3 polyunsaturated fatty acid (PUFA) content and increased n-6 PUFA levels in the salmon fillets, in the prepared WDs, and in red blood cells collected from mice consuming the WDs. Replacing FO with VO did not influence obesity development in the mice, but replacement of FO with RO improved glucose tolerance. Compared with WD-FO fed mice, feeding mice WD-SO containing lower PCB and DDT levels but high levels of linoleic acid (LA), exaggerated insulin resistance and increased accumulation of fat in the liver. CONCLUSION/SIGNIFICANCE: Replacement of FO with VOs in aqua feed for farmed salmon had markedly different spillover effects on metabolism in mice. Our results suggest that the content of LA in VOs may be a matter of concern that warrants further investigation. Article in Journal/Newspaper Atlantic salmon Salmo salar Directory of Open Access Journals: DOAJ Articles PLoS ONE 8 1 e53094 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Lisa Kolden Midtbø Mohammad Madani Ibrahim Lene Secher Myrmel Ulrike Liisberg Aune Anita Røyneberg Alvheim Nina S Liland Bente E Torstensen Grethe Rosenlund Bjørn Liaset Trond Brattelid Karsten Kristiansen Lise Madsen Intake of farmed Atlantic salmon fed soybean oil increases insulin resistance and hepatic lipid accumulation in mice. |
topic_facet |
Medicine R Science Q |
description |
BACKGROUND: To ensure sustainable aquaculture, fish derived raw materials are replaced by vegetable ingredients. Fatty acid composition and contaminant status of farmed Atlantic salmon (Salmo salar L.) are affected by the use of plant ingredients and a spillover effect on consumers is thus expected. Here we aimed to compare the effects of intake of Atlantic salmon fed fish oil (FO) with intake of Atlantic salmon fed a high proportion of vegetable oils (VOs) on development of insulin resistance and obesity in mice. METHODOLOGY/PRINCIPAL FINDINGS: Atlantic salmon were fed diets where FO was partly (80%) replaced with three different VOs; rapeseed oil (RO), olive oil (OO) or soy bean oil (SO). Fillets from Atlantic salmon were subsequently used to prepare Western diets (WD) for a mouse feeding trial. Partial replacement of FO with VOs reduced the levels of polychlorinated biphenyls (PCB) and dichloro-diphenyl-tricloroethanes (DDT) with more than 50% in salmon fillets, in WDs containing the fillets, and in white adipose tissue from mice consuming the WDs. Replacement with VOs, SO in particular, lowered the n-3 polyunsaturated fatty acid (PUFA) content and increased n-6 PUFA levels in the salmon fillets, in the prepared WDs, and in red blood cells collected from mice consuming the WDs. Replacing FO with VO did not influence obesity development in the mice, but replacement of FO with RO improved glucose tolerance. Compared with WD-FO fed mice, feeding mice WD-SO containing lower PCB and DDT levels but high levels of linoleic acid (LA), exaggerated insulin resistance and increased accumulation of fat in the liver. CONCLUSION/SIGNIFICANCE: Replacement of FO with VOs in aqua feed for farmed salmon had markedly different spillover effects on metabolism in mice. Our results suggest that the content of LA in VOs may be a matter of concern that warrants further investigation. |
format |
Article in Journal/Newspaper |
author |
Lisa Kolden Midtbø Mohammad Madani Ibrahim Lene Secher Myrmel Ulrike Liisberg Aune Anita Røyneberg Alvheim Nina S Liland Bente E Torstensen Grethe Rosenlund Bjørn Liaset Trond Brattelid Karsten Kristiansen Lise Madsen |
author_facet |
Lisa Kolden Midtbø Mohammad Madani Ibrahim Lene Secher Myrmel Ulrike Liisberg Aune Anita Røyneberg Alvheim Nina S Liland Bente E Torstensen Grethe Rosenlund Bjørn Liaset Trond Brattelid Karsten Kristiansen Lise Madsen |
author_sort |
Lisa Kolden Midtbø |
title |
Intake of farmed Atlantic salmon fed soybean oil increases insulin resistance and hepatic lipid accumulation in mice. |
title_short |
Intake of farmed Atlantic salmon fed soybean oil increases insulin resistance and hepatic lipid accumulation in mice. |
title_full |
Intake of farmed Atlantic salmon fed soybean oil increases insulin resistance and hepatic lipid accumulation in mice. |
title_fullStr |
Intake of farmed Atlantic salmon fed soybean oil increases insulin resistance and hepatic lipid accumulation in mice. |
title_full_unstemmed |
Intake of farmed Atlantic salmon fed soybean oil increases insulin resistance and hepatic lipid accumulation in mice. |
title_sort |
intake of farmed atlantic salmon fed soybean oil increases insulin resistance and hepatic lipid accumulation in mice. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doi.org/10.1371/journal.pone.0053094 https://doaj.org/article/9bb5d5e7dc0a44d6bdd2807e13e38515 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
PLoS ONE, Vol 8, Iss 1, p e53094 (2013) |
op_relation |
http://europepmc.org/articles/PMC3534660?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0053094 https://doaj.org/article/9bb5d5e7dc0a44d6bdd2807e13e38515 |
op_doi |
https://doi.org/10.1371/journal.pone.0053094 |
container_title |
PLoS ONE |
container_volume |
8 |
container_issue |
1 |
container_start_page |
e53094 |
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1766359999023415296 |