The rs738409 (I148M) Variant of the PNPLA3 Gene and Type 2 Diabetes in Yakutia

The purpose of our research was to study the association of the PNPLA3 SNP rs738409 (C>G) with type 2 diabetes (T2D) in the Yakuts. The frequency distribution of alleles and genotypes of the PNPLA3 rs738409 SNP was in accordance with HWE. There were no statistically significant differences in the...

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Bibliographic Details
Published in:International Journal of Biomedicine
Main Authors: Lubov A. Sydykova, Khariton A. Kurtanov, Natalia V. Borisova, Nadejda I. Pavlova, Konstantin M. Stepanov, Sardana V. Markova, Albert D. Makarov, Sardana N. Alekseeva, Uliana D. Antipina
Format: Article in Journal/Newspaper
Language:English
Published: International Medical Research and Development Corporation 2018
Subjects:
type 2 diabetes
gene polymorphism
non-alcoholic fatty liver disease
Yakut population
Medicine
R
Yakutia
Yakuts
Online Access:https://doi.org/10.21103/Article8(3)_OA6
https://doaj.org/article/9b881e8d99b146d39dab6c36ab851866
Description
Summary:The purpose of our research was to study the association of the PNPLA3 SNP rs738409 (C>G) with type 2 diabetes (T2D) in the Yakuts. The frequency distribution of alleles and genotypes of the PNPLA3 rs738409 SNP was in accordance with HWE. There were no statistically significant differences in the distribution of alleles and genotypes of the PNPLA3 SNP rs738409 (C>G) between T2D patients and non-T2D patients (P>0.05); the G allele and homozygous GG genotype prevailed in both groups. In T2D patients, a high frequency of the G allele (74.1%) was found, with a predominance of the GG genotype (58.5%). We also found that the mutant allele frequency is higher than in the studied populations of the world. Further studies with larger sample size are required to achieve sufficient statistical power to detect the association of the PNPLA3 SNP (rs738409 with the development of T2D in Yakut patients.

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