Molecular epidemiology of dengue fever outbreaks in Bhutan, 2016-2017.
Dengue continues to pose a significant public health problem in tropical and subtropical countries. In Bhutan, first outbreak of dengue fever (DF) was reported in 2004 in a southern border town, followed by sporadic cases over the years. In this study, we analysed DF outbreaks that occurred in 3 dif...
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Online Access: | https://doi.org/10.1371/journal.pntd.0008165 https://doaj.org/article/9b67fc0b08ee41d2b66875dfd6d3f08d |
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ftdoajarticles:oai:doaj.org/article:9b67fc0b08ee41d2b66875dfd6d3f08d 2023-05-15T15:03:04+02:00 Molecular epidemiology of dengue fever outbreaks in Bhutan, 2016-2017. Sangay Zangmo Jit Bdr Darnal Tsheten Sonam Gyeltshen Binay Thapa Thapa Prinyada Rodpradit Piyawan Chinnawirotpisan Wudtichai Manasatienkij Louis R Macareo Stefan Fernandez Sonam Wangchuk Chonticha Klungthong 2020-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008165 https://doaj.org/article/9b67fc0b08ee41d2b66875dfd6d3f08d EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008165 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008165 https://doaj.org/article/9b67fc0b08ee41d2b66875dfd6d3f08d PLoS Neglected Tropical Diseases, Vol 14, Iss 4, p e0008165 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008165 2022-12-31T13:48:02Z Dengue continues to pose a significant public health problem in tropical and subtropical countries. In Bhutan, first outbreak of dengue fever (DF) was reported in 2004 in a southern border town, followed by sporadic cases over the years. In this study, we analysed DF outbreaks that occurred in 3 different places during the years 2016 and 2017. A total of 533 cases in 2016 and 163 in 2017 were suspected of having of DF, where young adults were mostly affected. A total of 240 acute serum specimens collected and analyzed for serotype by nested RT-PCR revealed predominance of serotypes 1 and 2 (DENV-1 and 2). Phylogenetic analysis using envelope gene for both the serotypes demonstrated cosmopolitan genotype which were closely related to strains from India, indicating that they were probably imported from the neighboring country over the past few years. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 4 e0008165 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Sangay Zangmo Jit Bdr Darnal Tsheten Sonam Gyeltshen Binay Thapa Thapa Prinyada Rodpradit Piyawan Chinnawirotpisan Wudtichai Manasatienkij Louis R Macareo Stefan Fernandez Sonam Wangchuk Chonticha Klungthong Molecular epidemiology of dengue fever outbreaks in Bhutan, 2016-2017. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Dengue continues to pose a significant public health problem in tropical and subtropical countries. In Bhutan, first outbreak of dengue fever (DF) was reported in 2004 in a southern border town, followed by sporadic cases over the years. In this study, we analysed DF outbreaks that occurred in 3 different places during the years 2016 and 2017. A total of 533 cases in 2016 and 163 in 2017 were suspected of having of DF, where young adults were mostly affected. A total of 240 acute serum specimens collected and analyzed for serotype by nested RT-PCR revealed predominance of serotypes 1 and 2 (DENV-1 and 2). Phylogenetic analysis using envelope gene for both the serotypes demonstrated cosmopolitan genotype which were closely related to strains from India, indicating that they were probably imported from the neighboring country over the past few years. |
format |
Article in Journal/Newspaper |
author |
Sangay Zangmo Jit Bdr Darnal Tsheten Sonam Gyeltshen Binay Thapa Thapa Prinyada Rodpradit Piyawan Chinnawirotpisan Wudtichai Manasatienkij Louis R Macareo Stefan Fernandez Sonam Wangchuk Chonticha Klungthong |
author_facet |
Sangay Zangmo Jit Bdr Darnal Tsheten Sonam Gyeltshen Binay Thapa Thapa Prinyada Rodpradit Piyawan Chinnawirotpisan Wudtichai Manasatienkij Louis R Macareo Stefan Fernandez Sonam Wangchuk Chonticha Klungthong |
author_sort |
Sangay Zangmo |
title |
Molecular epidemiology of dengue fever outbreaks in Bhutan, 2016-2017. |
title_short |
Molecular epidemiology of dengue fever outbreaks in Bhutan, 2016-2017. |
title_full |
Molecular epidemiology of dengue fever outbreaks in Bhutan, 2016-2017. |
title_fullStr |
Molecular epidemiology of dengue fever outbreaks in Bhutan, 2016-2017. |
title_full_unstemmed |
Molecular epidemiology of dengue fever outbreaks in Bhutan, 2016-2017. |
title_sort |
molecular epidemiology of dengue fever outbreaks in bhutan, 2016-2017. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008165 https://doaj.org/article/9b67fc0b08ee41d2b66875dfd6d3f08d |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 4, p e0008165 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008165 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008165 https://doaj.org/article/9b67fc0b08ee41d2b66875dfd6d3f08d |
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https://doi.org/10.1371/journal.pntd.0008165 |
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PLOS Neglected Tropical Diseases |
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14 |
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4 |
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e0008165 |
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