Young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis?
The unfavorable evolution of a young ovine during hyperimmunization process with Crotalus durissus terrificus venom was investigated in order to differentiate its origin between ophidic envenomation and copper toxicosis. Clinical, laboratory, necroscopic and histological exams as well as evaluation...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
SciELO
2008
|
Subjects: | |
Online Access: | https://doi.org/10.1590/S1678-91992008000400015 https://doaj.org/article/9b512b02114f4596828575af2df53057 |
id |
ftdoajarticles:oai:doaj.org/article:9b512b02114f4596828575af2df53057 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:9b512b02114f4596828575af2df53057 2023-05-15T15:06:36+02:00 Young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis? RS Ferreira Junior N Nascimento R Couto JB Alves DA Meira B Barraviera 2008-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992008000400015 https://doaj.org/article/9b512b02114f4596828575af2df53057 EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000400015 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992008000400015 1678-9199 https://doaj.org/article/9b512b02114f4596828575af2df53057 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 14, Iss 4, Pp 738-749 (2008) differential diagnosis copper toxicosis ovines crotalic venom hyperimmunization Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2008 ftdoajarticles https://doi.org/10.1590/S1678-91992008000400015 2022-12-31T03:53:02Z The unfavorable evolution of a young ovine during hyperimmunization process with Crotalus durissus terrificus venom was investigated in order to differentiate its origin between ophidic envenomation and copper toxicosis. Clinical, laboratory, necroscopic and histological exams as well as evaluation and measurement of heavy metals (copper) in the kidneys and in the liver were carried out. Blood counts revealed anemia and serological tests showed high levels of blood urea nitrogen, creatinine, aspartate aminotransferase, creatine phosphokinase, total bilirubin and indirect bilirubin; which indicates liver, kidney and skeletal muscle damages. At necropsy, the animal presented hepatopathy and nephropathy. Histological examination revealed renal and hepatic features that may imply copper intoxication. Copper levels were 237.8 µg/g in the liver and 51.2 µg/g in the kidneys. Although the amount of metal found in both organs was below the level that can cause death, according to the literature, anatomopathological signs were suggestive of copper intoxication. Therefore, the hypothesis of metal toxicosis during the hyperimmunization process became more consistent than the crotalic envenomation one. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 14 4 738 749 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
differential diagnosis copper toxicosis ovines crotalic venom hyperimmunization Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
differential diagnosis copper toxicosis ovines crotalic venom hyperimmunization Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 RS Ferreira Junior N Nascimento R Couto JB Alves DA Meira B Barraviera Young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis? |
topic_facet |
differential diagnosis copper toxicosis ovines crotalic venom hyperimmunization Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
The unfavorable evolution of a young ovine during hyperimmunization process with Crotalus durissus terrificus venom was investigated in order to differentiate its origin between ophidic envenomation and copper toxicosis. Clinical, laboratory, necroscopic and histological exams as well as evaluation and measurement of heavy metals (copper) in the kidneys and in the liver were carried out. Blood counts revealed anemia and serological tests showed high levels of blood urea nitrogen, creatinine, aspartate aminotransferase, creatine phosphokinase, total bilirubin and indirect bilirubin; which indicates liver, kidney and skeletal muscle damages. At necropsy, the animal presented hepatopathy and nephropathy. Histological examination revealed renal and hepatic features that may imply copper intoxication. Copper levels were 237.8 µg/g in the liver and 51.2 µg/g in the kidneys. Although the amount of metal found in both organs was below the level that can cause death, according to the literature, anatomopathological signs were suggestive of copper intoxication. Therefore, the hypothesis of metal toxicosis during the hyperimmunization process became more consistent than the crotalic envenomation one. |
format |
Article in Journal/Newspaper |
author |
RS Ferreira Junior N Nascimento R Couto JB Alves DA Meira B Barraviera |
author_facet |
RS Ferreira Junior N Nascimento R Couto JB Alves DA Meira B Barraviera |
author_sort |
RS Ferreira Junior |
title |
Young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis? |
title_short |
Young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis? |
title_full |
Young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis? |
title_fullStr |
Young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis? |
title_full_unstemmed |
Young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis? |
title_sort |
young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis? |
publisher |
SciELO |
publishDate |
2008 |
url |
https://doi.org/10.1590/S1678-91992008000400015 https://doaj.org/article/9b512b02114f4596828575af2df53057 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 14, Iss 4, Pp 738-749 (2008) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000400015 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992008000400015 1678-9199 https://doaj.org/article/9b512b02114f4596828575af2df53057 |
op_doi |
https://doi.org/10.1590/S1678-91992008000400015 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
14 |
container_issue |
4 |
container_start_page |
738 |
op_container_end_page |
749 |
_version_ |
1766338177644101632 |