In search of the Aplysia immunome: an in silico study
Abstract The immune repertoires of mollusks beyond commercially important organisms such as the pacific oyster Crassostrea gigas or vectors for human pathogens like the bloodfluke planorb Biomphalaria glabrata are understudied. Despite being an important model for neural aging and the role of inflam...
Published in: | BMC Genomics |
---|---|
Main Author: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2022
|
Subjects: | |
Online Access: | https://doi.org/10.1186/s12864-022-08780-6 https://doaj.org/article/9b4e6f54059046b283879a140992a6bd |
id |
ftdoajarticles:oai:doaj.org/article:9b4e6f54059046b283879a140992a6bd |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:9b4e6f54059046b283879a140992a6bd 2023-05-15T15:58:46+02:00 In search of the Aplysia immunome: an in silico study Nicholas S. Kron 2022-07-01T00:00:00Z https://doi.org/10.1186/s12864-022-08780-6 https://doaj.org/article/9b4e6f54059046b283879a140992a6bd EN eng BMC https://doi.org/10.1186/s12864-022-08780-6 https://doaj.org/toc/1471-2164 doi:10.1186/s12864-022-08780-6 1471-2164 https://doaj.org/article/9b4e6f54059046b283879a140992a6bd BMC Genomics, Vol 23, Iss 1, Pp 1-29 (2022) Innate immunity Toll-like receptor RIG-I-like receptor MAVS STING (min. 3-max. 10) Biotechnology TP248.13-248.65 Genetics QH426-470 article 2022 ftdoajarticles https://doi.org/10.1186/s12864-022-08780-6 2022-12-31T00:48:14Z Abstract The immune repertoires of mollusks beyond commercially important organisms such as the pacific oyster Crassostrea gigas or vectors for human pathogens like the bloodfluke planorb Biomphalaria glabrata are understudied. Despite being an important model for neural aging and the role of inflammation in neuropathic pain, the immune repertoire of Aplysia californica is poorly understood. Recent discovery of a neurotropic nidovirus in Aplysia has highlighted the need for a better understanding of the Aplysia immunome. To address this gap in the literature, the Aplysia reference genome was mined using InterProScan and OrthoFinder for putative immune genes. The Aplysia genome encodes orthologs of all critical components of the classical Toll-like receptor (TLR) signaling pathway. The presence of many more TLRs and TLR associated adapters than known from vertebrates suggest yet uncharacterized, novel TLR associated signaling pathways. Aplysia also retains many nucleotide receptors and antiviral effectors known to play a key role in viral defense in vertebrates. However, the absence of key antiviral signaling adapters MAVS and STING in the Aplysia genome suggests divergence from vertebrates and bivalves in these pathways. The resulting immune gene set of this in silico study provides a basis for interpretation of future immune studies in this important model organism. Article in Journal/Newspaper Crassostrea gigas Pacific oyster Directory of Open Access Journals: DOAJ Articles Pacific BMC Genomics 23 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Innate immunity Toll-like receptor RIG-I-like receptor MAVS STING (min. 3-max. 10) Biotechnology TP248.13-248.65 Genetics QH426-470 |
spellingShingle |
Innate immunity Toll-like receptor RIG-I-like receptor MAVS STING (min. 3-max. 10) Biotechnology TP248.13-248.65 Genetics QH426-470 Nicholas S. Kron In search of the Aplysia immunome: an in silico study |
topic_facet |
Innate immunity Toll-like receptor RIG-I-like receptor MAVS STING (min. 3-max. 10) Biotechnology TP248.13-248.65 Genetics QH426-470 |
description |
Abstract The immune repertoires of mollusks beyond commercially important organisms such as the pacific oyster Crassostrea gigas or vectors for human pathogens like the bloodfluke planorb Biomphalaria glabrata are understudied. Despite being an important model for neural aging and the role of inflammation in neuropathic pain, the immune repertoire of Aplysia californica is poorly understood. Recent discovery of a neurotropic nidovirus in Aplysia has highlighted the need for a better understanding of the Aplysia immunome. To address this gap in the literature, the Aplysia reference genome was mined using InterProScan and OrthoFinder for putative immune genes. The Aplysia genome encodes orthologs of all critical components of the classical Toll-like receptor (TLR) signaling pathway. The presence of many more TLRs and TLR associated adapters than known from vertebrates suggest yet uncharacterized, novel TLR associated signaling pathways. Aplysia also retains many nucleotide receptors and antiviral effectors known to play a key role in viral defense in vertebrates. However, the absence of key antiviral signaling adapters MAVS and STING in the Aplysia genome suggests divergence from vertebrates and bivalves in these pathways. The resulting immune gene set of this in silico study provides a basis for interpretation of future immune studies in this important model organism. |
format |
Article in Journal/Newspaper |
author |
Nicholas S. Kron |
author_facet |
Nicholas S. Kron |
author_sort |
Nicholas S. Kron |
title |
In search of the Aplysia immunome: an in silico study |
title_short |
In search of the Aplysia immunome: an in silico study |
title_full |
In search of the Aplysia immunome: an in silico study |
title_fullStr |
In search of the Aplysia immunome: an in silico study |
title_full_unstemmed |
In search of the Aplysia immunome: an in silico study |
title_sort |
in search of the aplysia immunome: an in silico study |
publisher |
BMC |
publishDate |
2022 |
url |
https://doi.org/10.1186/s12864-022-08780-6 https://doaj.org/article/9b4e6f54059046b283879a140992a6bd |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
BMC Genomics, Vol 23, Iss 1, Pp 1-29 (2022) |
op_relation |
https://doi.org/10.1186/s12864-022-08780-6 https://doaj.org/toc/1471-2164 doi:10.1186/s12864-022-08780-6 1471-2164 https://doaj.org/article/9b4e6f54059046b283879a140992a6bd |
op_doi |
https://doi.org/10.1186/s12864-022-08780-6 |
container_title |
BMC Genomics |
container_volume |
23 |
container_issue |
1 |
_version_ |
1766394532049453056 |