SARS-CoV-2 variants in severely symptomatic and deceased persons who had been vaccinated against COVID-19 in São Paulo, Brazil
COVID-19 vaccination began in São Paulo, Brazil in January 2021, first targeting healthcare workers (HCWs) and the elderly, using the CoronaVac vaccine (Sinovac/Butantan) and subsequently the Oxford/AstraZeneca (ChAdOx1) vaccine (AstraZeneca/FIOCRUZ-RJ). Studies on such vaccines have shown efficacy...
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ftdoajarticles:oai:doaj.org/article:9b18369cb36a478399a518bf795f2b5b 2023-05-15T15:10:48+02:00 SARS-CoV-2 variants in severely symptomatic and deceased persons who had been vaccinated against COVID-19 in São Paulo, Brazil Karoline Rodrigues Campos Cláudio Tavares Sacchi Adriano Abbud Adele Caterino-de-Araujo 2021-10-01T00:00:00Z https://doi.org/10.26633/RPSP.2021.126 https://doaj.org/article/9b18369cb36a478399a518bf795f2b5b EN ES PT eng spa por Pan American Health Organization https://iris.paho.org/handle/10665.2/54838 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 doi:10.26633/RPSP.2021.126 https://doaj.org/article/9b18369cb36a478399a518bf795f2b5b Revista Panamericana de Salud Pública, Vol 45, Iss 126, Pp 1-5 (2021) betacoronavirus coronavirus infections vaccines cause of death risk groups brazil Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.26633/RPSP.2021.126 2022-12-31T10:02:58Z COVID-19 vaccination began in São Paulo, Brazil in January 2021, first targeting healthcare workers (HCWs) and the elderly, using the CoronaVac vaccine (Sinovac/Butantan) and subsequently the Oxford/AstraZeneca (ChAdOx1) vaccine (AstraZeneca/FIOCRUZ-RJ). Studies on such vaccines have shown efficacy in preventing severe cases and deaths, but there is a lack of information regarding their effectiveness. This manuscript presents data from the Instituto Adolfo Lutz (IAL), a public health laboratory located in São Paulo City that receives samples from 17 Regional Health Departments under the Secretary of Health of São Paulo, for SARS-CoV-2 genomic surveillance. Through May 15, 2021 IAL received 20 samples for analysis from COVID-19 vaccinated individuals who needed hospitalization and/or died from COVID-19. Next-generation sequencing was performed on an Ion Torrent S5 platform using the AmpliSeq SARS-CoV-2 kit. Almost all cases were vaccinated with CoronaVac and presented the gamma variant of concern (VOC). Cases of death were observed mostly in the elderly in nursing homes, and severe cases in younger frontline HCWs. This data confirmed that the SARS-CoV-2 gamma variant is highly transmissible, severe, and lethal for COVID-19 in these groups of individuals, thereby highlighting the importance of continuous vaccination and non-pharmacological prevention measures to avoid virus dissemination and the emergence of new VOCs. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista Panamericana de Salud Pública 45 1 |
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betacoronavirus coronavirus infections vaccines cause of death risk groups brazil Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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betacoronavirus coronavirus infections vaccines cause of death risk groups brazil Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Karoline Rodrigues Campos Cláudio Tavares Sacchi Adriano Abbud Adele Caterino-de-Araujo SARS-CoV-2 variants in severely symptomatic and deceased persons who had been vaccinated against COVID-19 in São Paulo, Brazil |
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betacoronavirus coronavirus infections vaccines cause of death risk groups brazil Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
COVID-19 vaccination began in São Paulo, Brazil in January 2021, first targeting healthcare workers (HCWs) and the elderly, using the CoronaVac vaccine (Sinovac/Butantan) and subsequently the Oxford/AstraZeneca (ChAdOx1) vaccine (AstraZeneca/FIOCRUZ-RJ). Studies on such vaccines have shown efficacy in preventing severe cases and deaths, but there is a lack of information regarding their effectiveness. This manuscript presents data from the Instituto Adolfo Lutz (IAL), a public health laboratory located in São Paulo City that receives samples from 17 Regional Health Departments under the Secretary of Health of São Paulo, for SARS-CoV-2 genomic surveillance. Through May 15, 2021 IAL received 20 samples for analysis from COVID-19 vaccinated individuals who needed hospitalization and/or died from COVID-19. Next-generation sequencing was performed on an Ion Torrent S5 platform using the AmpliSeq SARS-CoV-2 kit. Almost all cases were vaccinated with CoronaVac and presented the gamma variant of concern (VOC). Cases of death were observed mostly in the elderly in nursing homes, and severe cases in younger frontline HCWs. This data confirmed that the SARS-CoV-2 gamma variant is highly transmissible, severe, and lethal for COVID-19 in these groups of individuals, thereby highlighting the importance of continuous vaccination and non-pharmacological prevention measures to avoid virus dissemination and the emergence of new VOCs. |
format |
Article in Journal/Newspaper |
author |
Karoline Rodrigues Campos Cláudio Tavares Sacchi Adriano Abbud Adele Caterino-de-Araujo |
author_facet |
Karoline Rodrigues Campos Cláudio Tavares Sacchi Adriano Abbud Adele Caterino-de-Araujo |
author_sort |
Karoline Rodrigues Campos |
title |
SARS-CoV-2 variants in severely symptomatic and deceased persons who had been vaccinated against COVID-19 in São Paulo, Brazil |
title_short |
SARS-CoV-2 variants in severely symptomatic and deceased persons who had been vaccinated against COVID-19 in São Paulo, Brazil |
title_full |
SARS-CoV-2 variants in severely symptomatic and deceased persons who had been vaccinated against COVID-19 in São Paulo, Brazil |
title_fullStr |
SARS-CoV-2 variants in severely symptomatic and deceased persons who had been vaccinated against COVID-19 in São Paulo, Brazil |
title_full_unstemmed |
SARS-CoV-2 variants in severely symptomatic and deceased persons who had been vaccinated against COVID-19 in São Paulo, Brazil |
title_sort |
sars-cov-2 variants in severely symptomatic and deceased persons who had been vaccinated against covid-19 in são paulo, brazil |
publisher |
Pan American Health Organization |
publishDate |
2021 |
url |
https://doi.org/10.26633/RPSP.2021.126 https://doaj.org/article/9b18369cb36a478399a518bf795f2b5b |
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Arctic |
geographic_facet |
Arctic |
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Arctic |
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Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 45, Iss 126, Pp 1-5 (2021) |
op_relation |
https://iris.paho.org/handle/10665.2/54838 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 doi:10.26633/RPSP.2021.126 https://doaj.org/article/9b18369cb36a478399a518bf795f2b5b |
op_doi |
https://doi.org/10.26633/RPSP.2021.126 |
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Revista Panamericana de Salud Pública |
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45 |
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