Epidemiologic features and environmental risk factors of severe fever with thrombocytopenia syndrome, Xinyang, China.
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease discovered in rural areas of Central China in 2009, caused by a novel bunyavirus, SFTS virus (SFTSV). The disease usually presents as fever, thrombocytopenia, and leukocytopenia, with case-fatality rates...
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ftdoajarticles:oai:doaj.org/article:9b0beac9ac91415e942efc213eeebedb 2023-05-15T15:15:14+02:00 Epidemiologic features and environmental risk factors of severe fever with thrombocytopenia syndrome, Xinyang, China. Kun Liu Ning Cui Li-Qun Fang Bing-Jun Wang Qing-Bin Lu Wei Peng Hao Li Li-Yuan Wang Song Liang Hong-Yu Wang Yao-Yun Zhang Lu Zhuang Hong Yang Gregory C Gray Sake J de Vlas Wei Liu Wu-Chun Cao 2014-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002820 https://doaj.org/article/9b0beac9ac91415e942efc213eeebedb EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4014392?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002820 https://doaj.org/article/9b0beac9ac91415e942efc213eeebedb PLoS Neglected Tropical Diseases, Vol 8, Iss 5, p e2820 (2014) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2014 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002820 2022-12-31T13:04:59Z BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease discovered in rural areas of Central China in 2009, caused by a novel bunyavirus, SFTS virus (SFTSV). The disease usually presents as fever, thrombocytopenia, and leukocytopenia, with case-fatality rates ranging from 2.5% to 30%. Haemaphysalis longicornis was suspected to be the most likely vector of SFTSV. By the end of 2012, the disease had expanded to 13 provinces of China. SFTS patients have been reported in Japan and South Korea, and a disease similar to SFTS has been reported in the United States. METHODOLOGY/PRINCIPAL FINDINGS: We characterized the epidemiologic features of 504 confirmed SFTS cases in Xinyang Region, the most severely SFTS-afflicted region in China from 2011 to 2012, and assessed the environmental risk factors. All cases occurred during March to November, with the epidemic peaking from May to July. The patients' ages ranged from 7 to 87 years (median 61 years), and the annual incidence increased with age (χ2 test for trend, P<0.001). The female-to-male ratio of cases was 1.58, and 97.0% of the cases were farmers who resided in the southern and western parts of the region. The Poisson regression analysis revealed that the spatial variations of SFTS incidence were significantly associated with the shrub, forest, and rain-fed cropland areas. CONCLUSIONS: The distribution of SFTS showed highly significant temporal and spatial heterogeneity in Xinyang Region, with the majority of SFTS cases being elderly farmers who resided in the southern and western parts of the region, mostly acquiring infection between May and July when H. longicornis is highly active. The shrub, rain-fed, and rain-fed cropland areas were associated with high risk for this disease. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 8 5 e2820 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Kun Liu Ning Cui Li-Qun Fang Bing-Jun Wang Qing-Bin Lu Wei Peng Hao Li Li-Yuan Wang Song Liang Hong-Yu Wang Yao-Yun Zhang Lu Zhuang Hong Yang Gregory C Gray Sake J de Vlas Wei Liu Wu-Chun Cao Epidemiologic features and environmental risk factors of severe fever with thrombocytopenia syndrome, Xinyang, China. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease discovered in rural areas of Central China in 2009, caused by a novel bunyavirus, SFTS virus (SFTSV). The disease usually presents as fever, thrombocytopenia, and leukocytopenia, with case-fatality rates ranging from 2.5% to 30%. Haemaphysalis longicornis was suspected to be the most likely vector of SFTSV. By the end of 2012, the disease had expanded to 13 provinces of China. SFTS patients have been reported in Japan and South Korea, and a disease similar to SFTS has been reported in the United States. METHODOLOGY/PRINCIPAL FINDINGS: We characterized the epidemiologic features of 504 confirmed SFTS cases in Xinyang Region, the most severely SFTS-afflicted region in China from 2011 to 2012, and assessed the environmental risk factors. All cases occurred during March to November, with the epidemic peaking from May to July. The patients' ages ranged from 7 to 87 years (median 61 years), and the annual incidence increased with age (χ2 test for trend, P<0.001). The female-to-male ratio of cases was 1.58, and 97.0% of the cases were farmers who resided in the southern and western parts of the region. The Poisson regression analysis revealed that the spatial variations of SFTS incidence were significantly associated with the shrub, forest, and rain-fed cropland areas. CONCLUSIONS: The distribution of SFTS showed highly significant temporal and spatial heterogeneity in Xinyang Region, with the majority of SFTS cases being elderly farmers who resided in the southern and western parts of the region, mostly acquiring infection between May and July when H. longicornis is highly active. The shrub, rain-fed, and rain-fed cropland areas were associated with high risk for this disease. |
format |
Article in Journal/Newspaper |
author |
Kun Liu Ning Cui Li-Qun Fang Bing-Jun Wang Qing-Bin Lu Wei Peng Hao Li Li-Yuan Wang Song Liang Hong-Yu Wang Yao-Yun Zhang Lu Zhuang Hong Yang Gregory C Gray Sake J de Vlas Wei Liu Wu-Chun Cao |
author_facet |
Kun Liu Ning Cui Li-Qun Fang Bing-Jun Wang Qing-Bin Lu Wei Peng Hao Li Li-Yuan Wang Song Liang Hong-Yu Wang Yao-Yun Zhang Lu Zhuang Hong Yang Gregory C Gray Sake J de Vlas Wei Liu Wu-Chun Cao |
author_sort |
Kun Liu |
title |
Epidemiologic features and environmental risk factors of severe fever with thrombocytopenia syndrome, Xinyang, China. |
title_short |
Epidemiologic features and environmental risk factors of severe fever with thrombocytopenia syndrome, Xinyang, China. |
title_full |
Epidemiologic features and environmental risk factors of severe fever with thrombocytopenia syndrome, Xinyang, China. |
title_fullStr |
Epidemiologic features and environmental risk factors of severe fever with thrombocytopenia syndrome, Xinyang, China. |
title_full_unstemmed |
Epidemiologic features and environmental risk factors of severe fever with thrombocytopenia syndrome, Xinyang, China. |
title_sort |
epidemiologic features and environmental risk factors of severe fever with thrombocytopenia syndrome, xinyang, china. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pntd.0002820 https://doaj.org/article/9b0beac9ac91415e942efc213eeebedb |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 8, Iss 5, p e2820 (2014) |
op_relation |
http://europepmc.org/articles/PMC4014392?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002820 https://doaj.org/article/9b0beac9ac91415e942efc213eeebedb |
op_doi |
https://doi.org/10.1371/journal.pntd.0002820 |
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PLoS Neglected Tropical Diseases |
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8 |
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5 |
container_start_page |
e2820 |
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1766345602694643712 |