Transient Ascaris suum larval migration induces intractable chronic pulmonary disease and anemia in mice.
Ascariasis is one of the most common infections in the world and associated with significant global morbidity. Ascaris larval migration through the host's lungs is essential for larval development but leads to an exaggerated type-2 host immune response manifesting clinically as acute allergic a...
Published in: | PLOS Neglected Tropical Diseases |
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Online Access: | https://doi.org/10.1371/journal.pntd.0010050 https://doaj.org/article/9aacc5138edf459eba62a113517836c7 |
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ftdoajarticles:oai:doaj.org/article:9aacc5138edf459eba62a113517836c7 2023-05-15T15:04:35+02:00 Transient Ascaris suum larval migration induces intractable chronic pulmonary disease and anemia in mice. Yifan Wu Evan Li Morgan Knight Grace Adeniyi-Ipadeola Li-Zhen Song Alan R Burns Ana Clara Gazzinelli-Guimaraes Ricardo Fujiwara Maria Elena Bottazzi Jill E Weatherhead 2021-12-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010050 https://doaj.org/article/9aacc5138edf459eba62a113517836c7 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010050 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010050 https://doaj.org/article/9aacc5138edf459eba62a113517836c7 PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0010050 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010050 2022-12-30T19:37:04Z Ascariasis is one of the most common infections in the world and associated with significant global morbidity. Ascaris larval migration through the host's lungs is essential for larval development but leads to an exaggerated type-2 host immune response manifesting clinically as acute allergic airway disease. However, whether Ascaris larval migration can subsequently lead to chronic lung diseases remains unknown. Here, we demonstrate that a single episode of Ascaris larval migration through the host lungs induces a chronic pulmonary syndrome of type-2 inflammatory pathology and emphysema accompanied by pulmonary hemorrhage and chronic anemia in a mouse model. Our results reveal that a single episode of Ascaris larval migration through the host lungs leads to permanent lung damage with systemic effects. Remote episodes of ascariasis may drive non-communicable lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), and chronic anemia in parasite endemic regions. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 12 e0010050 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Yifan Wu Evan Li Morgan Knight Grace Adeniyi-Ipadeola Li-Zhen Song Alan R Burns Ana Clara Gazzinelli-Guimaraes Ricardo Fujiwara Maria Elena Bottazzi Jill E Weatherhead Transient Ascaris suum larval migration induces intractable chronic pulmonary disease and anemia in mice. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Ascariasis is one of the most common infections in the world and associated with significant global morbidity. Ascaris larval migration through the host's lungs is essential for larval development but leads to an exaggerated type-2 host immune response manifesting clinically as acute allergic airway disease. However, whether Ascaris larval migration can subsequently lead to chronic lung diseases remains unknown. Here, we demonstrate that a single episode of Ascaris larval migration through the host lungs induces a chronic pulmonary syndrome of type-2 inflammatory pathology and emphysema accompanied by pulmonary hemorrhage and chronic anemia in a mouse model. Our results reveal that a single episode of Ascaris larval migration through the host lungs leads to permanent lung damage with systemic effects. Remote episodes of ascariasis may drive non-communicable lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), and chronic anemia in parasite endemic regions. |
format |
Article in Journal/Newspaper |
author |
Yifan Wu Evan Li Morgan Knight Grace Adeniyi-Ipadeola Li-Zhen Song Alan R Burns Ana Clara Gazzinelli-Guimaraes Ricardo Fujiwara Maria Elena Bottazzi Jill E Weatherhead |
author_facet |
Yifan Wu Evan Li Morgan Knight Grace Adeniyi-Ipadeola Li-Zhen Song Alan R Burns Ana Clara Gazzinelli-Guimaraes Ricardo Fujiwara Maria Elena Bottazzi Jill E Weatherhead |
author_sort |
Yifan Wu |
title |
Transient Ascaris suum larval migration induces intractable chronic pulmonary disease and anemia in mice. |
title_short |
Transient Ascaris suum larval migration induces intractable chronic pulmonary disease and anemia in mice. |
title_full |
Transient Ascaris suum larval migration induces intractable chronic pulmonary disease and anemia in mice. |
title_fullStr |
Transient Ascaris suum larval migration induces intractable chronic pulmonary disease and anemia in mice. |
title_full_unstemmed |
Transient Ascaris suum larval migration induces intractable chronic pulmonary disease and anemia in mice. |
title_sort |
transient ascaris suum larval migration induces intractable chronic pulmonary disease and anemia in mice. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0010050 https://doaj.org/article/9aacc5138edf459eba62a113517836c7 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0010050 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010050 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010050 https://doaj.org/article/9aacc5138edf459eba62a113517836c7 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010050 |
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PLOS Neglected Tropical Diseases |
container_volume |
15 |
container_issue |
12 |
container_start_page |
e0010050 |
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1766336327614201856 |